Aptamers: current challenges and future prospects

Autores
Rozenblum, Tomas Guido; Lopez, Vanina Gisela; Vitullo, Alfredo Daniel; Radrizzani Helguera, Martin
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial libraries of nucleic acids and developed to bind to targets with high affinity and specificity. Whereas novel target molecules are proposed for therapeutic intervention and diagnostic, aptamer technology has a great potential to become a source of lead compounds.Areas Covered: In this review the authors address the current status of the technology and highlight the recent progress in aptamer-based technologies. They also discuss the current major technical limitations of aptamer technology and propose original solutions based on existing technologies that could result in a solid aptamer-discovery platform.Expert opinion: Whereas aptamers have shown to bind to targets with similar affinities and specificities to those of antibodies, aptamers have several advantages that could outweigh antibody technology and open new opportunities for better medical and diagnostic solutions. However, the current status of the aptamer technology suffers from several technical limitations that slowdown the progression of novel aptamers into the clinic and makes the business around aptamers challenging.
Fil: Rozenblum, Tomas Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides; Argentina
Fil: Lopez, Vanina Gisela. Universidad Maimónides; Argentina
Fil: Vitullo, Alfredo Daniel. Universidad Maimónides; Argentina
Fil: Radrizzani Helguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín; Argentina
Materia
Aptamer
Biosensors
Lead Discovery
Dna Array
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43257
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Aptamers: current challenges and future prospectsRozenblum, Tomas GuidoLopez, Vanina GiselaVitullo, Alfredo DanielRadrizzani Helguera, MartinAptamerBiosensorsLead DiscoveryDna Arrayhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial libraries of nucleic acids and developed to bind to targets with high affinity and specificity. Whereas novel target molecules are proposed for therapeutic intervention and diagnostic, aptamer technology has a great potential to become a source of lead compounds.Areas Covered: In this review the authors address the current status of the technology and highlight the recent progress in aptamer-based technologies. They also discuss the current major technical limitations of aptamer technology and propose original solutions based on existing technologies that could result in a solid aptamer-discovery platform.Expert opinion: Whereas aptamers have shown to bind to targets with similar affinities and specificities to those of antibodies, aptamers have several advantages that could outweigh antibody technology and open new opportunities for better medical and diagnostic solutions. However, the current status of the aptamer technology suffers from several technical limitations that slowdown the progression of novel aptamers into the clinic and makes the business around aptamers challenging.Fil: Rozenblum, Tomas Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides; ArgentinaFil: Lopez, Vanina Gisela. Universidad Maimónides; ArgentinaFil: Vitullo, Alfredo Daniel. Universidad Maimónides; ArgentinaFil: Radrizzani Helguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín; ArgentinaInforma Healthcare2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43257Rozenblum, Tomas Guido; Lopez, Vanina Gisela; Vitullo, Alfredo Daniel; Radrizzani Helguera, Martin; Aptamers: current challenges and future prospects; Informa Healthcare; Expert Opinion On Drug Discovery; 11; 2; 12-2015; 127-1351746-0441CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1517/17460441.2016.1126244info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1517/17460441.2016.1126244info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:32Zoai:ri.conicet.gov.ar:11336/43257instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:33.199CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aptamers: current challenges and future prospects
title Aptamers: current challenges and future prospects
spellingShingle Aptamers: current challenges and future prospects
Rozenblum, Tomas Guido
Aptamer
Biosensors
Lead Discovery
Dna Array
title_short Aptamers: current challenges and future prospects
title_full Aptamers: current challenges and future prospects
title_fullStr Aptamers: current challenges and future prospects
title_full_unstemmed Aptamers: current challenges and future prospects
title_sort Aptamers: current challenges and future prospects
dc.creator.none.fl_str_mv Rozenblum, Tomas Guido
Lopez, Vanina Gisela
Vitullo, Alfredo Daniel
Radrizzani Helguera, Martin
author Rozenblum, Tomas Guido
author_facet Rozenblum, Tomas Guido
Lopez, Vanina Gisela
Vitullo, Alfredo Daniel
Radrizzani Helguera, Martin
author_role author
author2 Lopez, Vanina Gisela
Vitullo, Alfredo Daniel
Radrizzani Helguera, Martin
author2_role author
author
author
dc.subject.none.fl_str_mv Aptamer
Biosensors
Lead Discovery
Dna Array
topic Aptamer
Biosensors
Lead Discovery
Dna Array
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial libraries of nucleic acids and developed to bind to targets with high affinity and specificity. Whereas novel target molecules are proposed for therapeutic intervention and diagnostic, aptamer technology has a great potential to become a source of lead compounds.Areas Covered: In this review the authors address the current status of the technology and highlight the recent progress in aptamer-based technologies. They also discuss the current major technical limitations of aptamer technology and propose original solutions based on existing technologies that could result in a solid aptamer-discovery platform.Expert opinion: Whereas aptamers have shown to bind to targets with similar affinities and specificities to those of antibodies, aptamers have several advantages that could outweigh antibody technology and open new opportunities for better medical and diagnostic solutions. However, the current status of the aptamer technology suffers from several technical limitations that slowdown the progression of novel aptamers into the clinic and makes the business around aptamers challenging.
Fil: Rozenblum, Tomas Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides; Argentina
Fil: Lopez, Vanina Gisela. Universidad Maimónides; Argentina
Fil: Vitullo, Alfredo Daniel. Universidad Maimónides; Argentina
Fil: Radrizzani Helguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín; Argentina
description Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial libraries of nucleic acids and developed to bind to targets with high affinity and specificity. Whereas novel target molecules are proposed for therapeutic intervention and diagnostic, aptamer technology has a great potential to become a source of lead compounds.Areas Covered: In this review the authors address the current status of the technology and highlight the recent progress in aptamer-based technologies. They also discuss the current major technical limitations of aptamer technology and propose original solutions based on existing technologies that could result in a solid aptamer-discovery platform.Expert opinion: Whereas aptamers have shown to bind to targets with similar affinities and specificities to those of antibodies, aptamers have several advantages that could outweigh antibody technology and open new opportunities for better medical and diagnostic solutions. However, the current status of the aptamer technology suffers from several technical limitations that slowdown the progression of novel aptamers into the clinic and makes the business around aptamers challenging.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43257
Rozenblum, Tomas Guido; Lopez, Vanina Gisela; Vitullo, Alfredo Daniel; Radrizzani Helguera, Martin; Aptamers: current challenges and future prospects; Informa Healthcare; Expert Opinion On Drug Discovery; 11; 2; 12-2015; 127-135
1746-0441
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43257
identifier_str_mv Rozenblum, Tomas Guido; Lopez, Vanina Gisela; Vitullo, Alfredo Daniel; Radrizzani Helguera, Martin; Aptamers: current challenges and future prospects; Informa Healthcare; Expert Opinion On Drug Discovery; 11; 2; 12-2015; 127-135
1746-0441
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1517/17460441.2016.1126244
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1517/17460441.2016.1126244
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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