Aptamers as Diagnostic Tools in Cancer

Autores
Ruiz Ciancio, Dario Ezequiel; Vargas López, Mauricio Rubén; Thiel, William H.; Bruno, Martin A.; Giangrande, Paloma H.; Mestre, María Belén
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early detection methods, both critical to increasing treatment efficacy, and developing methods for disease prevention. The use of nucleic acids, or aptamers, has emerged as more specific and accurate cancer diagnostic and therapeutic tools. Aptamers are single-stranded DNA or RNA molecules that recognize specific targets based on unique three-dimensional conformations. Despite the fact aptamer development has been mainly restricted to laboratory settings, the unique attributes of these molecules suggest their high potential for clinical advances in cancer detection. Aptamers can be selected for a wide range of targets, and also linked with an extensive variety of diagnostic agents, via physical or chemical conjugation, to improve previously-established detection methods or to be used as novel biosensors for cancer diagnosis. Consequently, herein we review the principal considerations and recent updates in cancer detection and imaging through aptamer-based molecules.
Fil: Ruiz Ciancio, Dario Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Vargas López, Mauricio Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Thiel, William H.. University of Iowa; Estados Unidos
Fil: Bruno, Martin A.. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Giangrande, Paloma H.. University of Iowa; Estados Unidos
Fil: Mestre, María Belén. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Materia
APTAMER
CANCER
DIAGNOSIS
IMAGING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156207
Acceder
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spelling Aptamers as Diagnostic Tools in CancerRuiz Ciancio, Dario EzequielVargas López, Mauricio RubénThiel, William H.Bruno, Martin A.Giangrande, Paloma H.Mestre, María BelénAPTAMERCANCERDIAGNOSISIMAGINGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early detection methods, both critical to increasing treatment efficacy, and developing methods for disease prevention. The use of nucleic acids, or aptamers, has emerged as more specific and accurate cancer diagnostic and therapeutic tools. Aptamers are single-stranded DNA or RNA molecules that recognize specific targets based on unique three-dimensional conformations. Despite the fact aptamer development has been mainly restricted to laboratory settings, the unique attributes of these molecules suggest their high potential for clinical advances in cancer detection. Aptamers can be selected for a wide range of targets, and also linked with an extensive variety of diagnostic agents, via physical or chemical conjugation, to improve previously-established detection methods or to be used as novel biosensors for cancer diagnosis. Consequently, herein we review the principal considerations and recent updates in cancer detection and imaging through aptamer-based molecules.Fil: Ruiz Ciancio, Dario Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; ArgentinaFil: Vargas López, Mauricio Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; ArgentinaFil: Thiel, William H.. University of Iowa; Estados UnidosFil: Bruno, Martin A.. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; ArgentinaFil: Giangrande, Paloma H.. University of Iowa; Estados UnidosFil: Mestre, María Belén. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; ArgentinaMultidisciplinary Digital Publishing Institute2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156207Ruiz Ciancio, Dario Ezequiel; Vargas López, Mauricio Rubén; Thiel, William H.; Bruno, Martin A.; Giangrande, Paloma H.; et al.; Aptamers as Diagnostic Tools in Cancer; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 11; 3; 9-2018; 1-231424-8247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1424-8247/11/3/86info:eu-repo/semantics/altIdentifier/doi/10.3390/ph11030086info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:06Zoai:ri.conicet.gov.ar:11336/156207instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:07.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aptamers as Diagnostic Tools in Cancer
title Aptamers as Diagnostic Tools in Cancer
spellingShingle Aptamers as Diagnostic Tools in Cancer
Ruiz Ciancio, Dario Ezequiel
APTAMER
CANCER
DIAGNOSIS
IMAGING
title_short Aptamers as Diagnostic Tools in Cancer
title_full Aptamers as Diagnostic Tools in Cancer
title_fullStr Aptamers as Diagnostic Tools in Cancer
title_full_unstemmed Aptamers as Diagnostic Tools in Cancer
title_sort Aptamers as Diagnostic Tools in Cancer
dc.creator.none.fl_str_mv Ruiz Ciancio, Dario Ezequiel
Vargas López, Mauricio Rubén
Thiel, William H.
Bruno, Martin A.
Giangrande, Paloma H.
Mestre, María Belén
author Ruiz Ciancio, Dario Ezequiel
author_facet Ruiz Ciancio, Dario Ezequiel
Vargas López, Mauricio Rubén
Thiel, William H.
Bruno, Martin A.
Giangrande, Paloma H.
Mestre, María Belén
author_role author
author2 Vargas López, Mauricio Rubén
Thiel, William H.
Bruno, Martin A.
Giangrande, Paloma H.
Mestre, María Belén
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv APTAMER
CANCER
DIAGNOSIS
IMAGING
topic APTAMER
CANCER
DIAGNOSIS
IMAGING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early detection methods, both critical to increasing treatment efficacy, and developing methods for disease prevention. The use of nucleic acids, or aptamers, has emerged as more specific and accurate cancer diagnostic and therapeutic tools. Aptamers are single-stranded DNA or RNA molecules that recognize specific targets based on unique three-dimensional conformations. Despite the fact aptamer development has been mainly restricted to laboratory settings, the unique attributes of these molecules suggest their high potential for clinical advances in cancer detection. Aptamers can be selected for a wide range of targets, and also linked with an extensive variety of diagnostic agents, via physical or chemical conjugation, to improve previously-established detection methods or to be used as novel biosensors for cancer diagnosis. Consequently, herein we review the principal considerations and recent updates in cancer detection and imaging through aptamer-based molecules.
Fil: Ruiz Ciancio, Dario Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Vargas López, Mauricio Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Thiel, William H.. University of Iowa; Estados Unidos
Fil: Bruno, Martin A.. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
Fil: Giangrande, Paloma H.. University of Iowa; Estados Unidos
Fil: Mestre, María Belén. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
description Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early detection methods, both critical to increasing treatment efficacy, and developing methods for disease prevention. The use of nucleic acids, or aptamers, has emerged as more specific and accurate cancer diagnostic and therapeutic tools. Aptamers are single-stranded DNA or RNA molecules that recognize specific targets based on unique three-dimensional conformations. Despite the fact aptamer development has been mainly restricted to laboratory settings, the unique attributes of these molecules suggest their high potential for clinical advances in cancer detection. Aptamers can be selected for a wide range of targets, and also linked with an extensive variety of diagnostic agents, via physical or chemical conjugation, to improve previously-established detection methods or to be used as novel biosensors for cancer diagnosis. Consequently, herein we review the principal considerations and recent updates in cancer detection and imaging through aptamer-based molecules.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156207
Ruiz Ciancio, Dario Ezequiel; Vargas López, Mauricio Rubén; Thiel, William H.; Bruno, Martin A.; Giangrande, Paloma H.; et al.; Aptamers as Diagnostic Tools in Cancer; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 11; 3; 9-2018; 1-23
1424-8247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156207
identifier_str_mv Ruiz Ciancio, Dario Ezequiel; Vargas López, Mauricio Rubén; Thiel, William H.; Bruno, Martin A.; Giangrande, Paloma H.; et al.; Aptamers as Diagnostic Tools in Cancer; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 11; 3; 9-2018; 1-23
1424-8247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1424-8247/11/3/86
info:eu-repo/semantics/altIdentifier/doi/10.3390/ph11030086
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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