Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels

Autores
Chapela, Sebastián Pablo; Burgos, Hilda Isabel; Congost, Christian; Canzonieri, Romina; Muryan, Alexis; Alonso, Manuel; Stella, Carlos Alberto
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost. The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function. Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate. Systemic ROS are measured 24 hours after the procedure. Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07). There was no correlation between creatinine and systemic ROS levels (p=0.3). We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels. Since there is no correlation between both levels, the processes would not be related.
Fil: Chapela, Sebastián Pablo. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Burgos, Hilda Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Congost, Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Canzonieri, Romina. Hospital Británico de Buenos Aires; Argentina
Fil: Muryan, Alexis. Hospital Británico de Buenos Aires; Argentina
Fil: Alonso, Manuel. Universidad de Buenos Aires; Argentina
Fil: Stella, Carlos Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
Sepsis
ROS
Succinate
Intensive Care
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86776
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86776
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levelsChapela, Sebastián PabloBurgos, Hilda IsabelCongost, ChristianCanzonieri, RominaMuryan, AlexisAlonso, ManuelStella, Carlos AlbertoSepsisROSSuccinateIntensive Carehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost. The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function. Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate. Systemic ROS are measured 24 hours after the procedure. Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07). There was no correlation between creatinine and systemic ROS levels (p=0.3). We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels. Since there is no correlation between both levels, the processes would not be related.Fil: Chapela, Sebastián Pablo. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Burgos, Hilda Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Congost, Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Canzonieri, Romina. Hospital Británico de Buenos Aires; ArgentinaFil: Muryan, Alexis. Hospital Británico de Buenos Aires; ArgentinaFil: Alonso, Manuel. Universidad de Buenos Aires; ArgentinaFil: Stella, Carlos Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaLandes Bioscience2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86776Chapela, Sebastián Pablo; Burgos, Hilda Isabel; Congost, Christian; Canzonieri, Romina; Muryan, Alexis; et al.; Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2018; 11-2018; 1-61942-09001942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2018/1928945info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2018/1928945/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:30Zoai:ri.conicet.gov.ar:11336/86776instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:30.907CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
title Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
spellingShingle Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
Chapela, Sebastián Pablo
Sepsis
ROS
Succinate
Intensive Care
title_short Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
title_full Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
title_fullStr Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
title_full_unstemmed Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
title_sort Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels
dc.creator.none.fl_str_mv Chapela, Sebastián Pablo
Burgos, Hilda Isabel
Congost, Christian
Canzonieri, Romina
Muryan, Alexis
Alonso, Manuel
Stella, Carlos Alberto
author Chapela, Sebastián Pablo
author_facet Chapela, Sebastián Pablo
Burgos, Hilda Isabel
Congost, Christian
Canzonieri, Romina
Muryan, Alexis
Alonso, Manuel
Stella, Carlos Alberto
author_role author
author2 Burgos, Hilda Isabel
Congost, Christian
Canzonieri, Romina
Muryan, Alexis
Alonso, Manuel
Stella, Carlos Alberto
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Sepsis
ROS
Succinate
Intensive Care
topic Sepsis
ROS
Succinate
Intensive Care
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost. The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function. Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate. Systemic ROS are measured 24 hours after the procedure. Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07). There was no correlation between creatinine and systemic ROS levels (p=0.3). We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels. Since there is no correlation between both levels, the processes would not be related.
Fil: Chapela, Sebastián Pablo. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Burgos, Hilda Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Congost, Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Canzonieri, Romina. Hospital Británico de Buenos Aires; Argentina
Fil: Muryan, Alexis. Hospital Británico de Buenos Aires; Argentina
Fil: Alonso, Manuel. Universidad de Buenos Aires; Argentina
Fil: Stella, Carlos Alberto. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost. The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function. Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate. Systemic ROS are measured 24 hours after the procedure. Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07). There was no correlation between creatinine and systemic ROS levels (p=0.3). We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels. Since there is no correlation between both levels, the processes would not be related.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86776
Chapela, Sebastián Pablo; Burgos, Hilda Isabel; Congost, Christian; Canzonieri, Romina; Muryan, Alexis; et al.; Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2018; 11-2018; 1-6
1942-0900
1942-0994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86776
identifier_str_mv Chapela, Sebastián Pablo; Burgos, Hilda Isabel; Congost, Christian; Canzonieri, Romina; Muryan, Alexis; et al.; Parenteral succinate reduces systemic ROS production in septic rats, but it does not reduce creatinine levels; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2018; 11-2018; 1-6
1942-0900
1942-0994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/1928945
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2018/1928945/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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