Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.

Autores
Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; Rivadulla, Marcos Lois.; Pérez-García, Xenso; Gomez, Generosa; Pérez, Manuel; Fall, Yagamare.; Facchinetti, Maria Marta; Curino, Alejandro Carlos
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.
Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; Argentina
Fil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Materia
Antiproliferative Agents
Antitumor Activity
Cancer Treatment
Gemini
Cell Line
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4380
Acceder
id CONICETDig_18f472197230e6de8e206a6d1deeed57
oai_identifier_str oai:ri.conicet.gov.ar:11336/4380
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.Ferronato, María JuliaSalomón, Débora GiseleFermento, María EugeniaGandini, Norberto ArielLopez Romero, Alejandro.Rivadulla, Marcos Lois.Pérez-García, XensoGomez, GenerosaPérez, ManuelFall, Yagamare.Facchinetti, Maria MartaCurino, Alejandro CarlosAntiproliferative AgentsAntitumor ActivityCancer TreatmentGeminiCell Linehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; ArgentinaFil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaWiley Vch Verlag2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4380Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-150365-6233enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.v348.4/issuetocinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.201400448info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:50:35Zoai:ri.conicet.gov.ar:11336/4380instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:50:35.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
title Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
spellingShingle Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
Ferronato, María Julia
Antiproliferative Agents
Antitumor Activity
Cancer Treatment
Gemini
Cell Line
title_short Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
title_full Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
title_fullStr Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
title_full_unstemmed Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
title_sort Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
dc.creator.none.fl_str_mv Ferronato, María Julia
Salomón, Débora Gisele
Fermento, María Eugenia
Gandini, Norberto Ariel
Lopez Romero, Alejandro.
Rivadulla, Marcos Lois.
Pérez-García, Xenso
Gomez, Generosa
Pérez, Manuel
Fall, Yagamare.
Facchinetti, Maria Marta
Curino, Alejandro Carlos
author Ferronato, María Julia
author_facet Ferronato, María Julia
Salomón, Débora Gisele
Fermento, María Eugenia
Gandini, Norberto Ariel
Lopez Romero, Alejandro.
Rivadulla, Marcos Lois.
Pérez-García, Xenso
Gomez, Generosa
Pérez, Manuel
Fall, Yagamare.
Facchinetti, Maria Marta
Curino, Alejandro Carlos
author_role author
author2 Salomón, Débora Gisele
Fermento, María Eugenia
Gandini, Norberto Ariel
Lopez Romero, Alejandro.
Rivadulla, Marcos Lois.
Pérez-García, Xenso
Gomez, Generosa
Pérez, Manuel
Fall, Yagamare.
Facchinetti, Maria Marta
Curino, Alejandro Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antiproliferative Agents
Antitumor Activity
Cancer Treatment
Gemini
Cell Line
topic Antiproliferative Agents
Antitumor Activity
Cancer Treatment
Gemini
Cell Line
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.
Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; Argentina
Fil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
description The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4380
Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-15
0365-6233
url http://hdl.handle.net/11336/4380
identifier_str_mv Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-15
0365-6233
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.v348.4/issuetoc
info:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.201400448
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Vch Verlag
publisher.none.fl_str_mv Wiley Vch Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083030869868544
score 13.22299

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