Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
- Autores
- Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; Rivadulla, Marcos Lois.; Pérez-García, Xenso; Gomez, Generosa; Pérez, Manuel; Fall, Yagamare.; Facchinetti, Maria Marta; Curino, Alejandro Carlos
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.
Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; Argentina
Fil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; España
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina - Materia
-
Antiproliferative Agents
Antitumor Activity
Cancer Treatment
Gemini
Cell Line - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/4380
Ver los metadatos del registro completo
id |
CONICETDig_18f472197230e6de8e206a6d1deeed57 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/4380 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.Ferronato, María JuliaSalomón, Débora GiseleFermento, María EugeniaGandini, Norberto ArielLopez Romero, Alejandro.Rivadulla, Marcos Lois.Pérez-García, XensoGomez, GenerosaPérez, ManuelFall, Yagamare.Facchinetti, Maria MartaCurino, Alejandro CarlosAntiproliferative AgentsAntitumor ActivityCancer TreatmentGeminiCell Linehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; ArgentinaFil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; EspañaFil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaWiley Vch Verlag2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4380Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-150365-6233enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.v348.4/issuetocinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.201400448info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:36Zoai:ri.conicet.gov.ar:11336/4380instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:37.185CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
title |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
spellingShingle |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. Ferronato, María Julia Antiproliferative Agents Antitumor Activity Cancer Treatment Gemini Cell Line |
title_short |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
title_full |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
title_fullStr |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
title_full_unstemmed |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
title_sort |
Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. |
dc.creator.none.fl_str_mv |
Ferronato, María Julia Salomón, Débora Gisele Fermento, María Eugenia Gandini, Norberto Ariel Lopez Romero, Alejandro. Rivadulla, Marcos Lois. Pérez-García, Xenso Gomez, Generosa Pérez, Manuel Fall, Yagamare. Facchinetti, Maria Marta Curino, Alejandro Carlos |
author |
Ferronato, María Julia |
author_facet |
Ferronato, María Julia Salomón, Débora Gisele Fermento, María Eugenia Gandini, Norberto Ariel Lopez Romero, Alejandro. Rivadulla, Marcos Lois. Pérez-García, Xenso Gomez, Generosa Pérez, Manuel Fall, Yagamare. Facchinetti, Maria Marta Curino, Alejandro Carlos |
author_role |
author |
author2 |
Salomón, Débora Gisele Fermento, María Eugenia Gandini, Norberto Ariel Lopez Romero, Alejandro. Rivadulla, Marcos Lois. Pérez-García, Xenso Gomez, Generosa Pérez, Manuel Fall, Yagamare. Facchinetti, Maria Marta Curino, Alejandro Carlos |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Antiproliferative Agents Antitumor Activity Cancer Treatment Gemini Cell Line |
topic |
Antiproliferative Agents Antitumor Activity Cancer Treatment Gemini Cell Line |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays. Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina Fil: Lopez Romero, Alejandro.. Laboratorios IACA. Departamento de Hematología; Argentina Fil: Rivadulla, Marcos Lois.. Universidad de Vigo. Instituto de Investigación Biomédica; España Fil: Pérez-García, Xenso. Universidad de Vigo. Instituto de Investigación Biomédica; España Fil: Gomez, Generosa. Universidad de Vigo. Instituto de Investigación Biomédica; España Fil: Pérez, Manuel. Universidad de Vigo. Instituto de Investigación Biomédica; España Fil: Fall, Yagamare.. Universidad de Vigo. Instituto de Investigación Biomédica; España Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina |
description |
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumor doses are used. It has therefore been found necessary to synthesize new analogues that retain or even increase the antitumor effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoral effects over a wide panel of tumor cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/4380 Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-15 0365-6233 |
url |
http://hdl.handle.net/11336/4380 |
identifier_str_mv |
Ferronato, María Julia; Salomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Lopez Romero, Alejandro.; et al.; Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.; Wiley Vch Verlag; Archiv Der Pharmazie.; 348; 3-2015; 1-15 0365-6233 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.v348.4/issuetoc info:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.201400448 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Vch Verlag |
publisher.none.fl_str_mv |
Wiley Vch Verlag |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613675916197888 |
score |
13.070432 |