Antiproliferative activity of withanolides against human breast cancer cell lines

Autores
Machín, Rubén; Veleiro, Adriana Silvia; Nicotra, Viviana Estela; Oberti, Juan Carlos María; Padrón, José
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
Fil: Machín, Rubén. Hospital Universitario de Gran Canaria Dr. Negrín. Unidad de Investigación; España
Fil: Veleiro, Adriana Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos Aplicados A la Química Orgánica (i); Argentina; Argentina
Fil: Nicotra, Viviana Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Oberti, Juan Carlos María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Padrón, José. Universidad de La Laguna. BioLab. Instituto Universitario de Bio-Orgánica “Antonio González”; España
Materia
Withanolides
Solanaceae
Antiproliferative Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15769
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Antiproliferative activity of withanolides against human breast cancer cell linesMachín, RubénVeleiro, Adriana SilviaNicotra, Viviana EstelaOberti, Juan Carlos MaríaPadrón, JoséWithanolidesSolanaceaeAntiproliferative Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.Fil: Machín, Rubén. Hospital Universitario de Gran Canaria Dr. Negrín. Unidad de Investigación; EspañaFil: Veleiro, Adriana Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos Aplicados A la Química Orgánica (i); Argentina; ArgentinaFil: Nicotra, Viviana Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; ArgentinaFil: Oberti, Juan Carlos María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; ArgentinaFil: Padrón, José. Universidad de La Laguna. BioLab. Instituto Universitario de Bio-Orgánica “Antonio González”; EspañaAmerican Chemical Society2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15769Machín, Rubén; Veleiro, Adriana Silvia; Nicotra, Viviana Estela; Oberti, Juan Carlos María; Padrón, José; Antiproliferative activity of withanolides against human breast cancer cell lines; American Chemical Society; Journal Of Natural Products; 73; 5; 5-2010; 966-9680163-38641520-6025enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/np9006734info:eu-repo/semantics/altIdentifier/doi/10.1021/np9006734info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:32:16Zoai:ri.conicet.gov.ar:11336/15769instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:32:17.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antiproliferative activity of withanolides against human breast cancer cell lines
title Antiproliferative activity of withanolides against human breast cancer cell lines
spellingShingle Antiproliferative activity of withanolides against human breast cancer cell lines
Machín, Rubén
Withanolides
Solanaceae
Antiproliferative Activity
title_short Antiproliferative activity of withanolides against human breast cancer cell lines
title_full Antiproliferative activity of withanolides against human breast cancer cell lines
title_fullStr Antiproliferative activity of withanolides against human breast cancer cell lines
title_full_unstemmed Antiproliferative activity of withanolides against human breast cancer cell lines
title_sort Antiproliferative activity of withanolides against human breast cancer cell lines
dc.creator.none.fl_str_mv Machín, Rubén
Veleiro, Adriana Silvia
Nicotra, Viviana Estela
Oberti, Juan Carlos María
Padrón, José
author Machín, Rubén
author_facet Machín, Rubén
Veleiro, Adriana Silvia
Nicotra, Viviana Estela
Oberti, Juan Carlos María
Padrón, José
author_role author
author2 Veleiro, Adriana Silvia
Nicotra, Viviana Estela
Oberti, Juan Carlos María
Padrón, José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Withanolides
Solanaceae
Antiproliferative Activity
topic Withanolides
Solanaceae
Antiproliferative Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
Fil: Machín, Rubén. Hospital Universitario de Gran Canaria Dr. Negrín. Unidad de Investigación; España
Fil: Veleiro, Adriana Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos Aplicados A la Química Orgánica (i); Argentina; Argentina
Fil: Nicotra, Viviana Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Oberti, Juan Carlos María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina; Argentina
Fil: Padrón, José. Universidad de La Laguna. BioLab. Instituto Universitario de Bio-Orgánica “Antonio González”; España
description The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15769
Machín, Rubén; Veleiro, Adriana Silvia; Nicotra, Viviana Estela; Oberti, Juan Carlos María; Padrón, José; Antiproliferative activity of withanolides against human breast cancer cell lines; American Chemical Society; Journal Of Natural Products; 73; 5; 5-2010; 966-968
0163-3864
1520-6025
url http://hdl.handle.net/11336/15769
identifier_str_mv Machín, Rubén; Veleiro, Adriana Silvia; Nicotra, Viviana Estela; Oberti, Juan Carlos María; Padrón, José; Antiproliferative activity of withanolides against human breast cancer cell lines; American Chemical Society; Journal Of Natural Products; 73; 5; 5-2010; 966-968
0163-3864
1520-6025
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/np9006734
info:eu-repo/semantics/altIdentifier/doi/10.1021/np9006734
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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