Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor

Autores
Scaramuzza, Rocío Gala; Subires, Ana Laura; Abate, Paula; Balaszczuk, Veronica
Año de publicación
2020
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Literature shows that prenatal alcohol exposure have teratogenic effects on brain structure and occasioned long lasting cognitive and behavioral disturbances including attention deficit and deficits in memory. Omega-3, the essential fatty acids found in fish oil could have protective effects against ethanol-induced neurotoxicity. The aim of this study was to explore the acute alcohol long term effects in spatial memory in infant rats, and study the potential protective effects of Omega 3 against these effect. Method. A 20% solution of ethanol in saline was administered to postnatal day 7 (PND) Wistar rats in two separate treatments, 2 hours apart, each treatment delivering 2.5 g/kg (sc); control rats were treated with saline only. Another group was administered with one dose of Omega3 (720mg/kg, ig) 15' after the last alcohol injection. Spatial memory was analyzed in the Barnes test on PND 20 and 30. Results. Acute ethanol exposure at PND 7 had long-lasting consequences. Preliminary data show that a single dose of Omega3 did not reverse these alcohol effects. Discussion. This is the first study to demonstrate that acute ethanol exposure occasioned spatial memory alterations that persist in the offspring. Protective propriety of Omega3 warrants further investigation. The knowledge about teratological effects induced by maternal alcohol intake a is critical for an effective prevention in vulnerable population.
Fil: Scaramuzza, Rocío Gala. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Subires, Ana Laura. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Córdoba
Argentina
Sociedad Argentina de Neurociencias
Materia
omega 3
alcohol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238418
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective FactorScaramuzza, Rocío GalaSubires, Ana LauraAbate, PaulaBalaszczuk, Veronicaomega 3alcoholhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Literature shows that prenatal alcohol exposure have teratogenic effects on brain structure and occasioned long lasting cognitive and behavioral disturbances including attention deficit and deficits in memory. Omega-3, the essential fatty acids found in fish oil could have protective effects against ethanol-induced neurotoxicity. The aim of this study was to explore the acute alcohol long term effects in spatial memory in infant rats, and study the potential protective effects of Omega 3 against these effect. Method. A 20% solution of ethanol in saline was administered to postnatal day 7 (PND) Wistar rats in two separate treatments, 2 hours apart, each treatment delivering 2.5 g/kg (sc); control rats were treated with saline only. Another group was administered with one dose of Omega3 (720mg/kg, ig) 15' after the last alcohol injection. Spatial memory was analyzed in the Barnes test on PND 20 and 30. Results. Acute ethanol exposure at PND 7 had long-lasting consequences. Preliminary data show that a single dose of Omega3 did not reverse these alcohol effects. Discussion. This is the first study to demonstrate that acute ethanol exposure occasioned spatial memory alterations that persist in the offspring. Protective propriety of Omega3 warrants further investigation. The knowledge about teratological effects induced by maternal alcohol intake a is critical for an effective prevention in vulnerable population.Fil: Scaramuzza, Rocío Gala. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Subires, Ana Laura. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaXXXIII Congreso Anual de la Sociedad Argentina de Investigación en NeurocienciasCórdobaArgentinaSociedad Argentina de NeurocienciasSociedad Argentina de Neurociencias2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238418Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Córdoba; Argentina; 2018; 311-311CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2022/01/SAN2018_Cordoba-UNC_libro-de-resumenes.pdfinfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:48:09Zoai:ri.conicet.gov.ar:11336/238418instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:48:09.969CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
title Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
spellingShingle Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
Scaramuzza, Rocío Gala
omega 3
alcohol
title_short Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
title_full Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
title_fullStr Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
title_full_unstemmed Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
title_sort Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor
dc.creator.none.fl_str_mv Scaramuzza, Rocío Gala
Subires, Ana Laura
Abate, Paula
Balaszczuk, Veronica
author Scaramuzza, Rocío Gala
author_facet Scaramuzza, Rocío Gala
Subires, Ana Laura
Abate, Paula
Balaszczuk, Veronica
author_role author
author2 Subires, Ana Laura
Abate, Paula
Balaszczuk, Veronica
author2_role author
author
author
dc.subject.none.fl_str_mv omega 3
alcohol
topic omega 3
alcohol
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Literature shows that prenatal alcohol exposure have teratogenic effects on brain structure and occasioned long lasting cognitive and behavioral disturbances including attention deficit and deficits in memory. Omega-3, the essential fatty acids found in fish oil could have protective effects against ethanol-induced neurotoxicity. The aim of this study was to explore the acute alcohol long term effects in spatial memory in infant rats, and study the potential protective effects of Omega 3 against these effect. Method. A 20% solution of ethanol in saline was administered to postnatal day 7 (PND) Wistar rats in two separate treatments, 2 hours apart, each treatment delivering 2.5 g/kg (sc); control rats were treated with saline only. Another group was administered with one dose of Omega3 (720mg/kg, ig) 15' after the last alcohol injection. Spatial memory was analyzed in the Barnes test on PND 20 and 30. Results. Acute ethanol exposure at PND 7 had long-lasting consequences. Preliminary data show that a single dose of Omega3 did not reverse these alcohol effects. Discussion. This is the first study to demonstrate that acute ethanol exposure occasioned spatial memory alterations that persist in the offspring. Protective propriety of Omega3 warrants further investigation. The knowledge about teratological effects induced by maternal alcohol intake a is critical for an effective prevention in vulnerable population.
Fil: Scaramuzza, Rocío Gala. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Subires, Ana Laura. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Córdoba
Argentina
Sociedad Argentina de Neurociencias
description Literature shows that prenatal alcohol exposure have teratogenic effects on brain structure and occasioned long lasting cognitive and behavioral disturbances including attention deficit and deficits in memory. Omega-3, the essential fatty acids found in fish oil could have protective effects against ethanol-induced neurotoxicity. The aim of this study was to explore the acute alcohol long term effects in spatial memory in infant rats, and study the potential protective effects of Omega 3 against these effect. Method. A 20% solution of ethanol in saline was administered to postnatal day 7 (PND) Wistar rats in two separate treatments, 2 hours apart, each treatment delivering 2.5 g/kg (sc); control rats were treated with saline only. Another group was administered with one dose of Omega3 (720mg/kg, ig) 15' after the last alcohol injection. Spatial memory was analyzed in the Barnes test on PND 20 and 30. Results. Acute ethanol exposure at PND 7 had long-lasting consequences. Preliminary data show that a single dose of Omega3 did not reverse these alcohol effects. Discussion. This is the first study to demonstrate that acute ethanol exposure occasioned spatial memory alterations that persist in the offspring. Protective propriety of Omega3 warrants further investigation. The knowledge about teratological effects induced by maternal alcohol intake a is critical for an effective prevention in vulnerable population.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238418
Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Córdoba; Argentina; 2018; 311-311
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238418
identifier_str_mv Alcohol Neurotoxicity Effect in Spatial Memory. Omega 3 as a Protective Factor; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Córdoba; Argentina; 2018; 311-311
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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