Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
- Autores
- Cabrera, Valentin; Macchione, Ana Fabiola; Abate, Paula; Balaszczuk, Veronica
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis - Materia
-
Ethanol
Omega 3
Adolescence
Anxiety
Spatial memory - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/233231
Ver los metadatos del registro completo
id |
CONICETDig_6dc9bf00e37d6a5d0d6af32cdbe2eea8 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/233231 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent ratsCabrera, ValentinMacchione, Ana FabiolaAbate, PaulaBalaszczuk, VeronicaEthanolOmega 3AdolescenceAnxietySpatial memoryhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaXXXVIII Annual Meeting of the Sociedad Argentina de Investigación en NeurocienciasSan LuisArgentinaSociedad Argentina de Investigación en NeurocienciasUniversidad Nacional de San LuisSociedad Argentina de Investigación en Neurociencias2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233231Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:05Zoai:ri.conicet.gov.ar:11336/233231instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:05.613CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
title |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
spellingShingle |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats Cabrera, Valentin Ethanol Omega 3 Adolescence Anxiety Spatial memory |
title_short |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
title_full |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
title_fullStr |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
title_full_unstemmed |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
title_sort |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats |
dc.creator.none.fl_str_mv |
Cabrera, Valentin Macchione, Ana Fabiola Abate, Paula Balaszczuk, Veronica |
author |
Cabrera, Valentin |
author_facet |
Cabrera, Valentin Macchione, Ana Fabiola Abate, Paula Balaszczuk, Veronica |
author_role |
author |
author2 |
Macchione, Ana Fabiola Abate, Paula Balaszczuk, Veronica |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Ethanol Omega 3 Adolescence Anxiety Spatial memory |
topic |
Ethanol Omega 3 Adolescence Anxiety Spatial memory |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents. Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias San Luis Argentina Sociedad Argentina de Investigación en Neurociencias Universidad Nacional de San Luis |
description |
The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/233231 Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/233231 |
identifier_str_mv |
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Nacional |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Investigación en Neurociencias |
publisher.none.fl_str_mv |
Sociedad Argentina de Investigación en Neurociencias |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613842513952768 |
score |
13.070432 |