Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats

Autores
Cabrera, Valentin; Macchione, Ana Fabiola; Abate, Paula; Balaszczuk, Veronica
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
Materia
Ethanol
Omega 3
Adolescence
Anxiety
Spatial memory
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/233231
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/233231
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent ratsCabrera, ValentinMacchione, Ana FabiolaAbate, PaulaBalaszczuk, VeronicaEthanolOmega 3AdolescenceAnxietySpatial memoryhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaXXXVIII Annual Meeting of the Sociedad Argentina de Investigación en NeurocienciasSan LuisArgentinaSociedad Argentina de Investigación en NeurocienciasUniversidad Nacional de San LuisSociedad Argentina de Investigación en Neurociencias2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233231Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:59:19Zoai:ri.conicet.gov.ar:11336/233231instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:59:19.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
title Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
spellingShingle Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
Cabrera, Valentin
Ethanol
Omega 3
Adolescence
Anxiety
Spatial memory
title_short Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
title_full Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
title_fullStr Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
title_full_unstemmed Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
title_sort Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats
dc.creator.none.fl_str_mv Cabrera, Valentin
Macchione, Ana Fabiola
Abate, Paula
Balaszczuk, Veronica
author Cabrera, Valentin
author_facet Cabrera, Valentin
Macchione, Ana Fabiola
Abate, Paula
Balaszczuk, Veronica
author_role author
author2 Macchione, Ana Fabiola
Abate, Paula
Balaszczuk, Veronica
author2_role author
author
author
dc.subject.none.fl_str_mv Ethanol
Omega 3
Adolescence
Anxiety
Spatial memory
topic Ethanol
Omega 3
Adolescence
Anxiety
Spatial memory
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
description The Panamerican Health Organization reports to Argentina among Latin American countries with the highest alcohol drinking per capita. Adolescents are among the most vulnerable to negative alcohol effects. Ethanol (EtOH) exposure may cause behavioral disorders related to anxiety and memory impairments. Besides, ω-3 mitigates EtOH-induced effects on anxiety-like behaviors and spatial memory in neonate or adult rats. Yet, no literature was found about these effects in adolescence.In this study, we analyze the behavioral effects of EtOH exposure and the possible mitigation of ω-3 or DHA (one of its main components) in adolescent Wistar rats. We administered 2 or 0g/kg of EtOH (ig) at postnatal days-PDs 28, 30 and 32. 15 min after, one set of animals received ω-3 (720mg/kg, ig) or its equivalent volume of corn oil and were evaluated in an elevated plus maze (PD36) to measure anxiety-like behavior. Other animal groups received DHA (1mg/kg, ip) or an equivalent volume of albumin and were evaluated in a Barnes maze to measure short- (PD36) and long-term (PD41) spatial memory.EtOH treated animals spend less time in open arms, but this time increases significantly in EtOH+ω-3 animals. Besides, EtOH animals traveled more distance prior to escape hole at PD41, but this variable decreases in EtOH+DHA animals. These results suggest that, while EtOH elicits anxiety-like behavior and impairs long-term spatial memory, ω-3 or DHA seem to mitigate both negative EtOH effects in adolescents.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/233231
Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257
CONICET Digital
CONICET
url http://hdl.handle.net/11336/233231
identifier_str_mv Binge-like ethanol exposure and possible amelioration of Omega-3 (ω-3) Fatty Acid on anxiety-like behavior and long-term spatial memory in adolescent rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 257-257
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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