Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury

Autores
Toro Urrego, Nicolas; Luaces, Juan Pablo; Aguilar, Andrea; Capani, Francisco
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hypoxic-ischemic (HI) brain injury is one of main causes of long-term neurologic disability, morbidity and death worldwide in adults and children. This public health concern is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to cell death by energy depletion and increases free radical generation and inflammation, caused by an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury occurs in perinatal asphyxia (PA), an obstetric complication associated with an impaired gas exchange. The incidence of PA is estimated at 1/1000 live births in developed countries. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, exert severalneuroprotective effects. ..
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Aguilar, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Materia
NEUROACTIVESTEROIDS
HYPOXIC-ISCHEMIC BRAIN INJURY
RALOXIFENE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140053
Acceder
id CONICETDig_122658490c02421e38caa0351c3d985e
oai_identifier_str oai:ri.conicet.gov.ar:11336/140053
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injuryToro Urrego, NicolasLuaces, Juan PabloAguilar, AndreaCapani, FranciscoNEUROACTIVESTEROIDSHYPOXIC-ISCHEMIC BRAIN INJURYRALOXIFENEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hypoxic-ischemic (HI) brain injury is one of main causes of long-term neurologic disability, morbidity and death worldwide in adults and children. This public health concern is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to cell death by energy depletion and increases free radical generation and inflammation, caused by an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury occurs in perinatal asphyxia (PA), an obstetric complication associated with an impaired gas exchange. The incidence of PA is estimated at 1/1000 live births in developed countries. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, exert severalneuroprotective effects. ..Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Aguilar, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaCambridge University Press2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140053Toro Urrego, Nicolas; Luaces, Juan Pablo; Aguilar, Andrea; Capani, Francisco; Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury; Cambridge University Press; Microscopy & Microanalysis; 26; S1; 4-2020; 129-1301431-9276CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S1431927620000860/type/journal_articleinfo:eu-repo/semantics/altIdentifier/doi/10.1017/S1431927620000860info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:49Zoai:ri.conicet.gov.ar:11336/140053instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:49.74CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
title Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
spellingShingle Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
Toro Urrego, Nicolas
NEUROACTIVESTEROIDS
HYPOXIC-ISCHEMIC BRAIN INJURY
RALOXIFENE
title_short Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
title_full Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
title_fullStr Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
title_full_unstemmed Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
title_sort Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury
dc.creator.none.fl_str_mv Toro Urrego, Nicolas
Luaces, Juan Pablo
Aguilar, Andrea
Capani, Francisco
author Toro Urrego, Nicolas
author_facet Toro Urrego, Nicolas
Luaces, Juan Pablo
Aguilar, Andrea
Capani, Francisco
author_role author
author2 Luaces, Juan Pablo
Aguilar, Andrea
Capani, Francisco
author2_role author
author
author
dc.subject.none.fl_str_mv NEUROACTIVESTEROIDS
HYPOXIC-ISCHEMIC BRAIN INJURY
RALOXIFENE
topic NEUROACTIVESTEROIDS
HYPOXIC-ISCHEMIC BRAIN INJURY
RALOXIFENE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hypoxic-ischemic (HI) brain injury is one of main causes of long-term neurologic disability, morbidity and death worldwide in adults and children. This public health concern is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to cell death by energy depletion and increases free radical generation and inflammation, caused by an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury occurs in perinatal asphyxia (PA), an obstetric complication associated with an impaired gas exchange. The incidence of PA is estimated at 1/1000 live births in developed countries. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, exert severalneuroprotective effects. ..
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Aguilar, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
description Hypoxic-ischemic (HI) brain injury is one of main causes of long-term neurologic disability, morbidity and death worldwide in adults and children. This public health concern is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to cell death by energy depletion and increases free radical generation and inflammation, caused by an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury occurs in perinatal asphyxia (PA), an obstetric complication associated with an impaired gas exchange. The incidence of PA is estimated at 1/1000 live births in developed countries. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, exert severalneuroprotective effects. ..
publishDate 2020
dc.date.none.fl_str_mv 2020-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140053
Toro Urrego, Nicolas; Luaces, Juan Pablo; Aguilar, Andrea; Capani, Francisco; Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury; Cambridge University Press; Microscopy & Microanalysis; 26; S1; 4-2020; 129-130
1431-9276
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140053
identifier_str_mv Toro Urrego, Nicolas; Luaces, Juan Pablo; Aguilar, Andrea; Capani, Francisco; Neuroactivesteroids as neuroprotective agents against the neurodegenerative effects induced by perinatal hypoxia-ischemia injury; Cambridge University Press; Microscopy & Microanalysis; 26; S1; 4-2020; 129-130
1431-9276
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S1431927620000860/type/journal_article
info:eu-repo/semantics/altIdentifier/doi/10.1017/S1431927620000860
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614389157593088
score 13.070432

Publicaciones similares