High cholesterol diet effects on ischemia- reperfusion injury of the heart

Autores
D'Anunzio, Verónica; Donato, Pablo Martín; Buchholz, Bruno; Perez, María Virginia; Miksztowicz, Verónica Julieta; Berg, Gabriela Alicia; Gelpi, Ricardo Jorge
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia-reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotec-tion against ischemia-reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.
Fil: D'Anunzio, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Donato, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Buchholz, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Perez, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Miksztowicz, Verónica Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Gelpi, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Materia
HYPERCHOLESTEROLEMIA
ISCHEMIA-REPERFUSION INJURY
ISCHEMIC POSTCONDITIONING
ISCHEMIC PRECONDITIONING
MYOCARDIAL INFARCTION
STATINS
VENTRICULAR FUNCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67423
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67423
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling High cholesterol diet effects on ischemia- reperfusion injury of the heartD'Anunzio, VerónicaDonato, Pablo MartínBuchholz, BrunoPerez, María VirginiaMiksztowicz, Verónica JulietaBerg, Gabriela AliciaGelpi, Ricardo JorgeHYPERCHOLESTEROLEMIAISCHEMIA-REPERFUSION INJURYISCHEMIC POSTCONDITIONINGISCHEMIC PRECONDITIONINGMYOCARDIAL INFARCTIONSTATINSVENTRICULAR FUNCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia-reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotec-tion against ischemia-reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.Fil: D'Anunzio, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaFil: Donato, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaFil: Buchholz, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaFil: Perez, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaFil: Miksztowicz, Verónica Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Gelpi, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaNational Research Council Canada-NRC Research Press2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67423D'Anunzio, Verónica; Donato, Pablo Martín; Buchholz, Bruno; Perez, María Virginia; Miksztowicz, Verónica Julieta; et al.; High cholesterol diet effects on ischemia- reperfusion injury of the heart; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1185-11960008-4212CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1139/y2012-085info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/y2012-085info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:43Zoai:ri.conicet.gov.ar:11336/67423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:43.362CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv High cholesterol diet effects on ischemia- reperfusion injury of the heart
title High cholesterol diet effects on ischemia- reperfusion injury of the heart
spellingShingle High cholesterol diet effects on ischemia- reperfusion injury of the heart
D'Anunzio, Verónica
HYPERCHOLESTEROLEMIA
ISCHEMIA-REPERFUSION INJURY
ISCHEMIC POSTCONDITIONING
ISCHEMIC PRECONDITIONING
MYOCARDIAL INFARCTION
STATINS
VENTRICULAR FUNCTION
title_short High cholesterol diet effects on ischemia- reperfusion injury of the heart
title_full High cholesterol diet effects on ischemia- reperfusion injury of the heart
title_fullStr High cholesterol diet effects on ischemia- reperfusion injury of the heart
title_full_unstemmed High cholesterol diet effects on ischemia- reperfusion injury of the heart
title_sort High cholesterol diet effects on ischemia- reperfusion injury of the heart
dc.creator.none.fl_str_mv D'Anunzio, Verónica
Donato, Pablo Martín
Buchholz, Bruno
Perez, María Virginia
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Gelpi, Ricardo Jorge
author D'Anunzio, Verónica
author_facet D'Anunzio, Verónica
Donato, Pablo Martín
Buchholz, Bruno
Perez, María Virginia
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Gelpi, Ricardo Jorge
author_role author
author2 Donato, Pablo Martín
Buchholz, Bruno
Perez, María Virginia
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Gelpi, Ricardo Jorge
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv HYPERCHOLESTEROLEMIA
ISCHEMIA-REPERFUSION INJURY
ISCHEMIC POSTCONDITIONING
ISCHEMIC PRECONDITIONING
MYOCARDIAL INFARCTION
STATINS
VENTRICULAR FUNCTION
topic HYPERCHOLESTEROLEMIA
ISCHEMIA-REPERFUSION INJURY
ISCHEMIC POSTCONDITIONING
ISCHEMIC PRECONDITIONING
MYOCARDIAL INFARCTION
STATINS
VENTRICULAR FUNCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia-reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotec-tion against ischemia-reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.
Fil: D'Anunzio, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Donato, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Buchholz, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Perez, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Miksztowicz, Verónica Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Gelpi, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
description Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia-reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotec-tion against ischemia-reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67423
D'Anunzio, Verónica; Donato, Pablo Martín; Buchholz, Bruno; Perez, María Virginia; Miksztowicz, Verónica Julieta; et al.; High cholesterol diet effects on ischemia- reperfusion injury of the heart; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1185-1196
0008-4212
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67423
identifier_str_mv D'Anunzio, Verónica; Donato, Pablo Martín; Buchholz, Bruno; Perez, María Virginia; Miksztowicz, Verónica Julieta; et al.; High cholesterol diet effects on ischemia- reperfusion injury of the heart; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1185-1196
0008-4212
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1139/y2012-085
info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/y2012-085
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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