Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen

Autores
Toro Urrego, Nicolas; Vesga Jiménez, Diego Julián; Herrera, María Inés; Luaces, Juan Pablo; Capani, Francisco
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Vesga Jiménez, Diego Julián. Pontificia Universidad Javeriana; Colombia
Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía; Argentina. Universidad Autónoma de Chile; Chile
Materia
COMBINED THERAPIES
HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROPROTECTIVE TREATMENTS
SELECTIVE ESTROGEN RECEPTOR MODULATORS
SELECTIVE TISSUE ESTROGENIC ACTIVITY REGULATORS
THERAPEUTIC HYPOTHERMIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97310
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/97310
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogenToro Urrego, NicolasVesga Jiménez, Diego JuliánHerrera, María InésLuaces, Juan PabloCapani, FranciscoCOMBINED THERAPIESHYPOXIC-ISCHEMIC BRAIN INJURYNEUROPROTECTIVE TREATMENTSSELECTIVE ESTROGEN RECEPTOR MODULATORSSELECTIVE TISSUE ESTROGENIC ACTIVITY REGULATORSTHERAPEUTIC HYPOTHERMIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Vesga Jiménez, Diego Julián. Pontificia Universidad Javeriana; ColombiaFil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía; Argentina. Universidad Autónoma de Chile; ChileBentham Science Publishers2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/97310Toro Urrego, Nicolas; Vesga Jiménez, Diego Julián; Herrera, María Inés; Luaces, Juan Pablo; Capani, Francisco; Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen; Bentham Science Publishers; Current Neuropharmacology; 17; 9; 12-2018; 874-8901570-159XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/node/168105/article/neuroprotective-role-of-hypothermia-in-hypoxic-ischemic-brain-injury-combined-therapies-using-estrogeninfo:eu-repo/semantics/altIdentifier/doi/10.2174/1570159X17666181206101314info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:32Zoai:ri.conicet.gov.ar:11336/97310instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:32.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
title Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
spellingShingle Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
Toro Urrego, Nicolas
COMBINED THERAPIES
HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROPROTECTIVE TREATMENTS
SELECTIVE ESTROGEN RECEPTOR MODULATORS
SELECTIVE TISSUE ESTROGENIC ACTIVITY REGULATORS
THERAPEUTIC HYPOTHERMIA
title_short Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
title_full Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
title_fullStr Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
title_full_unstemmed Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
title_sort Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
dc.creator.none.fl_str_mv Toro Urrego, Nicolas
Vesga Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author Toro Urrego, Nicolas
author_facet Toro Urrego, Nicolas
Vesga Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author_role author
author2 Vesga Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv COMBINED THERAPIES
HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROPROTECTIVE TREATMENTS
SELECTIVE ESTROGEN RECEPTOR MODULATORS
SELECTIVE TISSUE ESTROGENIC ACTIVITY REGULATORS
THERAPEUTIC HYPOTHERMIA
topic COMBINED THERAPIES
HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROPROTECTIVE TREATMENTS
SELECTIVE ESTROGEN RECEPTOR MODULATORS
SELECTIVE TISSUE ESTROGENIC ACTIVITY REGULATORS
THERAPEUTIC HYPOTHERMIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Vesga Jiménez, Diego Julián. Pontificia Universidad Javeriana; Colombia
Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Psicología y Psicopedagogía; Argentina. Universidad Autónoma de Chile; Chile
description Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97310
Toro Urrego, Nicolas; Vesga Jiménez, Diego Julián; Herrera, María Inés; Luaces, Juan Pablo; Capani, Francisco; Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen; Bentham Science Publishers; Current Neuropharmacology; 17; 9; 12-2018; 874-890
1570-159X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97310
identifier_str_mv Toro Urrego, Nicolas; Vesga Jiménez, Diego Julián; Herrera, María Inés; Luaces, Juan Pablo; Capani, Francisco; Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen; Bentham Science Publishers; Current Neuropharmacology; 17; 9; 12-2018; 874-890
1570-159X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/node/168105/article/neuroprotective-role-of-hypothermia-in-hypoxic-ischemic-brain-injury-combined-therapies-using-estrogen
info:eu-repo/semantics/altIdentifier/doi/10.2174/1570159X17666181206101314
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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