Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle
- Autores
- Cantón, Candela; Miller, Chris; Ceballos, Laura; Dominguez, Maria Paula; Waghorn, Tania; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Leathwick, Dave
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The current study evaluated the efficacy and the potential pharmacokinetic(PK) interactions occurring after the oral administration of abamectin(ABA) and oxfendazole(OXF) given both separately and co-administered to calves in two farms(A and B). On each farm sixty(60) male calves infected with gastrointestinal nematodes were randomly allocated into four groups(n= 15): Control: animals did not receive anthelmintic treatment; ABA: treated with ABA(0.2 mg/kg); OXF: treated with OXF(4.5 mg/kg); ABA+OXF: simultaneously treated with ABA and OXF(at the above doses). Seven(7) animals from each treated group(from Farm B) were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. A significantly(P<0.05) higher Cmax value was obtained for ABA alone(38.8±6.5 ng/mL), compared to that estimated after its co-administration with OXF(25.4±10.3ng ⁄mL). However, the ABA systemic exposure(expressed as AUC) obtained after administration of ABA alone(166±30.8 ng.d/mL) was similar to that observed in the ABA+OXF group(118±52.3 ng.d/mL). Likewise, OXF AUC values were similar after OXF administration alone(8.2±1.5 µg.h/mL) or combined with ABA(9.1±2.6 µg.h/mL). Overall, no adverse PK interactions were observed after the combined treatment. On Farm A, the Cooperia spp. were resistant to OXF, and the Ostertagia spp. were resistant to both ABA and OXF.Under this scenario the combined treatment only achieved an 84% efficacy against the multiple resistant Ostertagia spp.In contrast, on Farm B the Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, under the epidemiological conditions on Farm B, the combination was the only treatment that achieved 99.9% efficacy against all genera, indicating an additive effect of the combined treatment.Overall, an ABA+OXF combination can be useful to optimise the control of resistant gastrointestinal nematodes of cattle.However, its use must be necessarily supported by previous diagnosis of the resistant status of the nematode population.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Miller, Chris. AgResearch Grasslands; Nueva Zelanda
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Waghorn, Tania. AgResearch Grasslands; Nueva Zelanda
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Leathwick, Dave. AgResearch Grasslands; Nueva Zelanda
28th Conference of the World Association for the Advancement of Veterinary Parasitology
Dublin
Irlanda
World Association for the Advancement of Veterinary Parasitology
University College of Dublin - Materia
-
Abamectin
Oxfendazole
Cattle
Anthelmintic combination - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/156947
Ver los metadatos del registro completo
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Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattleCantón, CandelaMiller, ChrisCeballos, LauraDominguez, Maria PaulaWaghorn, TaniaLanusse, Carlos EdmundoAlvarez, Luis IgnacioLeathwick, DaveAbamectinOxfendazoleCattleAnthelmintic combinationhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The current study evaluated the efficacy and the potential pharmacokinetic(PK) interactions occurring after the oral administration of abamectin(ABA) and oxfendazole(OXF) given both separately and co-administered to calves in two farms(A and B). On each farm sixty(60) male calves infected with gastrointestinal nematodes were randomly allocated into four groups(n= 15): Control: animals did not receive anthelmintic treatment; ABA: treated with ABA(0.2 mg/kg); OXF: treated with OXF(4.5 mg/kg); ABA+OXF: simultaneously treated with ABA and OXF(at the above doses). Seven(7) animals from each treated group(from Farm B) were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. A significantly(P<0.05) higher Cmax value was obtained for ABA alone(38.8±6.5 ng/mL), compared to that estimated after its co-administration with OXF(25.4±10.3ng ⁄mL). However, the ABA systemic exposure(expressed as AUC) obtained after administration of ABA alone(166±30.8 ng.d/mL) was similar to that observed in the ABA+OXF group(118±52.3 ng.d/mL). Likewise, OXF AUC values were similar after OXF administration alone(8.2±1.5 µg.h/mL) or combined with ABA(9.1±2.6 µg.h/mL). Overall, no adverse PK interactions were observed after the combined treatment. On Farm A, the Cooperia spp. were resistant to OXF, and the Ostertagia spp. were resistant to both ABA and OXF.Under this scenario the combined treatment only achieved an 84% efficacy against the multiple resistant Ostertagia spp.In contrast, on Farm B the Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, under the epidemiological conditions on Farm B, the combination was the only treatment that achieved 99.9% efficacy against all genera, indicating an additive effect of the combined treatment.Overall, an ABA+OXF combination can be useful to optimise the control of resistant gastrointestinal nematodes of cattle.However, its use must be necessarily supported by previous diagnosis of the resistant status of the nematode population.Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Miller, Chris. AgResearch Grasslands; Nueva ZelandaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Waghorn, Tania. AgResearch Grasslands; Nueva ZelandaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Leathwick, Dave. AgResearch Grasslands; Nueva Zelanda28th Conference of the World Association for the Advancement of Veterinary ParasitologyDublinIrlandaWorld Association for the Advancement of Veterinary ParasitologyUniversity College of DublinWorld Association for the Advancement of Veterinary Parasitology2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/156947Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle; 28th Conference of the World Association for the Advancement of Veterinary Parasitology; Dublin; Irlanda; 2021; 348-349CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.waavp2021.com/info:eu-repo/semantics/altIdentifier/url/http://www.waavp2021.com/wp-content/uploads/2021/08/WAAVP-2021-Abstract-book-22.07.21-FINAL.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:09Zoai:ri.conicet.gov.ar:11336/156947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:10.127CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| title |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| spellingShingle |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle Cantón, Candela Abamectin Oxfendazole Cattle Anthelmintic combination |
| title_short |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| title_full |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| title_fullStr |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| title_full_unstemmed |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| title_sort |
Evaluation of the abamectin plus oxfendazole combination to control resistant nematodes in cattle |
| dc.creator.none.fl_str_mv |
Cantón, Candela Miller, Chris Ceballos, Laura Dominguez, Maria Paula Waghorn, Tania Lanusse, Carlos Edmundo Alvarez, Luis Ignacio Leathwick, Dave |
| author |
Cantón, Candela |
| author_facet |
Cantón, Candela Miller, Chris Ceballos, Laura Dominguez, Maria Paula Waghorn, Tania Lanusse, Carlos Edmundo Alvarez, Luis Ignacio Leathwick, Dave |
| author_role |
author |
| author2 |
Miller, Chris Ceballos, Laura Dominguez, Maria Paula Waghorn, Tania Lanusse, Carlos Edmundo Alvarez, Luis Ignacio Leathwick, Dave |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Abamectin Oxfendazole Cattle Anthelmintic combination |
| topic |
Abamectin Oxfendazole Cattle Anthelmintic combination |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
| dc.description.none.fl_txt_mv |
The current study evaluated the efficacy and the potential pharmacokinetic(PK) interactions occurring after the oral administration of abamectin(ABA) and oxfendazole(OXF) given both separately and co-administered to calves in two farms(A and B). On each farm sixty(60) male calves infected with gastrointestinal nematodes were randomly allocated into four groups(n= 15): Control: animals did not receive anthelmintic treatment; ABA: treated with ABA(0.2 mg/kg); OXF: treated with OXF(4.5 mg/kg); ABA+OXF: simultaneously treated with ABA and OXF(at the above doses). Seven(7) animals from each treated group(from Farm B) were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. A significantly(P<0.05) higher Cmax value was obtained for ABA alone(38.8±6.5 ng/mL), compared to that estimated after its co-administration with OXF(25.4±10.3ng ⁄mL). However, the ABA systemic exposure(expressed as AUC) obtained after administration of ABA alone(166±30.8 ng.d/mL) was similar to that observed in the ABA+OXF group(118±52.3 ng.d/mL). Likewise, OXF AUC values were similar after OXF administration alone(8.2±1.5 µg.h/mL) or combined with ABA(9.1±2.6 µg.h/mL). Overall, no adverse PK interactions were observed after the combined treatment. On Farm A, the Cooperia spp. were resistant to OXF, and the Ostertagia spp. were resistant to both ABA and OXF.Under this scenario the combined treatment only achieved an 84% efficacy against the multiple resistant Ostertagia spp.In contrast, on Farm B the Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, under the epidemiological conditions on Farm B, the combination was the only treatment that achieved 99.9% efficacy against all genera, indicating an additive effect of the combined treatment.Overall, an ABA+OXF combination can be useful to optimise the control of resistant gastrointestinal nematodes of cattle.However, its use must be necessarily supported by previous diagnosis of the resistant status of the nematode population. Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Miller, Chris. AgResearch Grasslands; Nueva Zelanda Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Waghorn, Tania. AgResearch Grasslands; Nueva Zelanda Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Leathwick, Dave. AgResearch Grasslands; Nueva Zelanda 28th Conference of the World Association for the Advancement of Veterinary Parasitology Dublin Irlanda World Association for the Advancement of Veterinary Parasitology University College of Dublin |
| description |
The current study evaluated the efficacy and the potential pharmacokinetic(PK) interactions occurring after the oral administration of abamectin(ABA) and oxfendazole(OXF) given both separately and co-administered to calves in two farms(A and B). On each farm sixty(60) male calves infected with gastrointestinal nematodes were randomly allocated into four groups(n= 15): Control: animals did not receive anthelmintic treatment; ABA: treated with ABA(0.2 mg/kg); OXF: treated with OXF(4.5 mg/kg); ABA+OXF: simultaneously treated with ABA and OXF(at the above doses). Seven(7) animals from each treated group(from Farm B) were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. A significantly(P<0.05) higher Cmax value was obtained for ABA alone(38.8±6.5 ng/mL), compared to that estimated after its co-administration with OXF(25.4±10.3ng ⁄mL). However, the ABA systemic exposure(expressed as AUC) obtained after administration of ABA alone(166±30.8 ng.d/mL) was similar to that observed in the ABA+OXF group(118±52.3 ng.d/mL). Likewise, OXF AUC values were similar after OXF administration alone(8.2±1.5 µg.h/mL) or combined with ABA(9.1±2.6 µg.h/mL). Overall, no adverse PK interactions were observed after the combined treatment. On Farm A, the Cooperia spp. were resistant to OXF, and the Ostertagia spp. were resistant to both ABA and OXF.Under this scenario the combined treatment only achieved an 84% efficacy against the multiple resistant Ostertagia spp.In contrast, on Farm B the Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, under the epidemiological conditions on Farm B, the combination was the only treatment that achieved 99.9% efficacy against all genera, indicating an additive effect of the combined treatment.Overall, an ABA+OXF combination can be useful to optimise the control of resistant gastrointestinal nematodes of cattle.However, its use must be necessarily supported by previous diagnosis of the resistant status of the nematode population. |
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2021 |
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