Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.

Autores
Alvarez, Luis Ignacio; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, Laura; Ceballos, Laura; Domingue, Guilbert; Donadeu, Meritxell; Dungu, Baptiste; Lanusse, Carlos Edmundo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n = 12 each), respectively. Each experiment involved two different groups (n = 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Saumell, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Fusé, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Moreno, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Domingue, Guilbert. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Donadeu, Meritxell. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Dungu, Baptiste. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Materia
Oxfendazole
Cerdos
Eficacia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/988
Acceder
id CONICETDig_f6dfcf7e7948d73e37582643894ff4e9
oai_identifier_str oai:ri.conicet.gov.ar:11336/988
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.Alvarez, Luis IgnacioSaumell, Carlos AlfredoFusé, LuisMoreno, LauraCeballos, LauraDomingue, GuilbertDonadeu, MeritxellDungu, BaptisteLanusse, Carlos EdmundoOxfendazoleCerdosEficaciahttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n = 12 each), respectively. Each experiment involved two different groups (n = 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Saumell, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Fusé, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Moreno, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Domingue, Guilbert. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;Fil: Donadeu, Meritxell. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;Fil: Dungu, Baptiste. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaElsevier Science Bv2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/988Alvarez, Luis Ignacio; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, Laura; Ceballos, Laura; et al.; Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.; Elsevier Science Bv; Veterinary Parasitology; 194; 10-2013; 70-740304-4017enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2013.01.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304401713000162info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:13Zoai:ri.conicet.gov.ar:11336/988instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:14.091CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
title Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
spellingShingle Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
Alvarez, Luis Ignacio
Oxfendazole
Cerdos
Eficacia
title_short Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
title_full Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
title_fullStr Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
title_full_unstemmed Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
title_sort Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
dc.creator.none.fl_str_mv Alvarez, Luis Ignacio
Saumell, Carlos Alfredo
Fusé, Luis
Moreno, Laura
Ceballos, Laura
Domingue, Guilbert
Donadeu, Meritxell
Dungu, Baptiste
Lanusse, Carlos Edmundo
author Alvarez, Luis Ignacio
author_facet Alvarez, Luis Ignacio
Saumell, Carlos Alfredo
Fusé, Luis
Moreno, Laura
Ceballos, Laura
Domingue, Guilbert
Donadeu, Meritxell
Dungu, Baptiste
Lanusse, Carlos Edmundo
author_role author
author2 Saumell, Carlos Alfredo
Fusé, Luis
Moreno, Laura
Ceballos, Laura
Domingue, Guilbert
Donadeu, Meritxell
Dungu, Baptiste
Lanusse, Carlos Edmundo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oxfendazole
Cerdos
Eficacia
topic Oxfendazole
Cerdos
Eficacia
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n = 12 each), respectively. Each experiment involved two different groups (n = 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Saumell, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Fusé, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Moreno, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Domingue, Guilbert. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Donadeu, Meritxell. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Dungu, Baptiste. GALVmed. Global Alliance for Livestock Veterinary Medicines; Reino Unido;
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
description The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n = 12 each), respectively. Each experiment involved two different groups (n = 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/988
Alvarez, Luis Ignacio; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, Laura; Ceballos, Laura; et al.; Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.; Elsevier Science Bv; Veterinary Parasitology; 194; 10-2013; 70-74
0304-4017
url http://hdl.handle.net/11336/988
identifier_str_mv Alvarez, Luis Ignacio; Saumell, Carlos Alfredo; Fusé, Luis; Moreno, Laura; Ceballos, Laura; et al.; Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.; Elsevier Science Bv; Veterinary Parasitology; 194; 10-2013; 70-74
0304-4017
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2013.01.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304401713000162
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Bv
publisher.none.fl_str_mv Elsevier Science Bv
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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