Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations

Autores
Cantón, Candela; Ceballos, Laura; Dominguez, Maria Paula; Cantón, Lucila; Buffarini, Miguel; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio
Año de publicación
2022
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In an attempt to minimize therapeutic failures following anthelmintic treatments, the combined use of nematodicidal compounds with different mechanisms of action has been proposed. A pharmaco-parasitological assessment of different nematodicidal combinations was performed on two commercial cattle farms in Argentina(A and B). Two different nematodicidal combinations of a macrocyclic lactone(ML) and a benzimidazole(BZD) anthelmintics were evaluated in a multi-resistant field scenario. Ivermectin(IVM)+ricobendazole(RBZ) both given subcutaneously and abamectin(ABA)+oxfendazole(OXF) both given orally were assessed in calves naturally infected with gastrointestinal nematodes resistant to both chemical families. The observed pharmacokinetic(PK) data demonstrated that the co-administration of two anthelmintics did not modify the plasma PK disposition of either drug in cattle. In fact, no adverse PK interactions were observed after each combined treatment, with no differences in PK parameters(P>0.05) observed between the single-drug and the combined-based strategies. While the observed initial efficacies were 40%(IVM), 64%(RBZ) and 90%(IVM+RBZ)(Farm A), the egg reductions were 54%(IVM), 84%(RBZ) and 98%(IVM-RBZ)(Farm B). After repeated annual(over 5 years) use of the same combination on both farms, the efficacy of the combined treatment decreased to 83% on Farm A. In contrast, the efficacy of the combination IVM-RBZ remained at 93% efficacy in Farm B .To optimize drug activity against those highly bi-resistant nematode population, oral combined treatments were assayed. Efficacies of ABA alone, OXF alone and the co-administration ABA+OXF were 62%, 88% and 99%, respectively(Farm A) and, 92%, 95% and 98%, respectively(Farm B).The Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, the combination ABA+OXF was the only treatment that achieved 99-100% efficacy against all genera, indicating the presence of an additive effect. Overall, anthelmintic combinations can be useful to optimize the control of resistant gastrointestinal nematodes of cattle.However, its rational use should be strongly supported by pre-treatment diagnosis and considering the epidemiological situation of each individual farm.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Buffarini, Miguel. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Buenos Aires Norte. Estacion Experimental Agropecuaria General Villegas.; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
67º Annual Meeting American Association of Veterinary Parasitologists
Snowbird
Estados Unidos
American Association of Veterinary Parasitologists
Materia
Cattle
Resistant nematodes
Anthelmintic combinations
Efficacy
Pharmacokinetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/221440
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/221440
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluationsCantón, CandelaCeballos, LauraDominguez, Maria PaulaCantón, LucilaBuffarini, MiguelLanusse, Carlos EdmundoAlvarez, Luis IgnacioCattleResistant nematodesAnthelmintic combinationsEfficacyPharmacokineticshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4In an attempt to minimize therapeutic failures following anthelmintic treatments, the combined use of nematodicidal compounds with different mechanisms of action has been proposed. A pharmaco-parasitological assessment of different nematodicidal combinations was performed on two commercial cattle farms in Argentina(A and B). Two different nematodicidal combinations of a macrocyclic lactone(ML) and a benzimidazole(BZD) anthelmintics were evaluated in a multi-resistant field scenario. Ivermectin(IVM)+ricobendazole(RBZ) both given subcutaneously and abamectin(ABA)+oxfendazole(OXF) both given orally were assessed in calves naturally infected with gastrointestinal nematodes resistant to both chemical families. The observed pharmacokinetic(PK) data demonstrated that the co-administration of two anthelmintics did not modify the plasma PK disposition of either drug in cattle. In fact, no adverse PK interactions were observed after each combined treatment, with no differences in PK parameters(P>0.05) observed between the single-drug and the combined-based strategies. While the observed initial efficacies were 40%(IVM), 64%(RBZ) and 90%(IVM+RBZ)(Farm A), the egg reductions were 54%(IVM), 84%(RBZ) and 98%(IVM-RBZ)(Farm B). After repeated annual(over 5 years) use of the same combination on both farms, the efficacy of the combined treatment decreased to 83% on Farm A. In contrast, the efficacy of the combination IVM-RBZ remained at 93% efficacy in Farm B .To optimize drug activity against those highly bi-resistant nematode population, oral combined treatments were assayed. Efficacies of ABA alone, OXF alone and the co-administration ABA+OXF were 62%, 88% and 99%, respectively(Farm A) and, 92%, 95% and 98%, respectively(Farm B).The Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, the combination ABA+OXF was the only treatment that achieved 99-100% efficacy against all genera, indicating the presence of an additive effect. Overall, anthelmintic combinations can be useful to optimize the control of resistant gastrointestinal nematodes of cattle.However, its rational use should be strongly supported by pre-treatment diagnosis and considering the epidemiological situation of each individual farm.Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Buffarini, Miguel. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Buenos Aires Norte. Estacion Experimental Agropecuaria General Villegas.; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina67º Annual Meeting American Association of Veterinary ParasitologistsSnowbirdEstados UnidosAmerican Association of Veterinary ParasitologistsAmerican Association of Veterinary Parasitologists2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/221440Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations; 67º Annual Meeting American Association of Veterinary Parasitologists; Snowbird; Estados Unidos; 2022; 106-106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aavp.org/documents/2022/07/aavp-2022-annual-meeting-proceedings.pdf/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:00Zoai:ri.conicet.gov.ar:11336/221440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:01.209CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
title Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
spellingShingle Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
Cantón, Candela
Cattle
Resistant nematodes
Anthelmintic combinations
Efficacy
Pharmacokinetics
title_short Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
title_full Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
title_fullStr Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
title_full_unstemmed Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
title_sort Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations
dc.creator.none.fl_str_mv Cantón, Candela
Ceballos, Laura
Dominguez, Maria Paula
Cantón, Lucila
Buffarini, Miguel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author Cantón, Candela
author_facet Cantón, Candela
Ceballos, Laura
Dominguez, Maria Paula
Cantón, Lucila
Buffarini, Miguel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author_role author
author2 Ceballos, Laura
Dominguez, Maria Paula
Cantón, Lucila
Buffarini, Miguel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cattle
Resistant nematodes
Anthelmintic combinations
Efficacy
Pharmacokinetics
topic Cattle
Resistant nematodes
Anthelmintic combinations
Efficacy
Pharmacokinetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In an attempt to minimize therapeutic failures following anthelmintic treatments, the combined use of nematodicidal compounds with different mechanisms of action has been proposed. A pharmaco-parasitological assessment of different nematodicidal combinations was performed on two commercial cattle farms in Argentina(A and B). Two different nematodicidal combinations of a macrocyclic lactone(ML) and a benzimidazole(BZD) anthelmintics were evaluated in a multi-resistant field scenario. Ivermectin(IVM)+ricobendazole(RBZ) both given subcutaneously and abamectin(ABA)+oxfendazole(OXF) both given orally were assessed in calves naturally infected with gastrointestinal nematodes resistant to both chemical families. The observed pharmacokinetic(PK) data demonstrated that the co-administration of two anthelmintics did not modify the plasma PK disposition of either drug in cattle. In fact, no adverse PK interactions were observed after each combined treatment, with no differences in PK parameters(P>0.05) observed between the single-drug and the combined-based strategies. While the observed initial efficacies were 40%(IVM), 64%(RBZ) and 90%(IVM+RBZ)(Farm A), the egg reductions were 54%(IVM), 84%(RBZ) and 98%(IVM-RBZ)(Farm B). After repeated annual(over 5 years) use of the same combination on both farms, the efficacy of the combined treatment decreased to 83% on Farm A. In contrast, the efficacy of the combination IVM-RBZ remained at 93% efficacy in Farm B .To optimize drug activity against those highly bi-resistant nematode population, oral combined treatments were assayed. Efficacies of ABA alone, OXF alone and the co-administration ABA+OXF were 62%, 88% and 99%, respectively(Farm A) and, 92%, 95% and 98%, respectively(Farm B).The Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, the combination ABA+OXF was the only treatment that achieved 99-100% efficacy against all genera, indicating the presence of an additive effect. Overall, anthelmintic combinations can be useful to optimize the control of resistant gastrointestinal nematodes of cattle.However, its rational use should be strongly supported by pre-treatment diagnosis and considering the epidemiological situation of each individual farm.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Buffarini, Miguel. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Buenos Aires Norte. Estacion Experimental Agropecuaria General Villegas.; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
67º Annual Meeting American Association of Veterinary Parasitologists
Snowbird
Estados Unidos
American Association of Veterinary Parasitologists
description In an attempt to minimize therapeutic failures following anthelmintic treatments, the combined use of nematodicidal compounds with different mechanisms of action has been proposed. A pharmaco-parasitological assessment of different nematodicidal combinations was performed on two commercial cattle farms in Argentina(A and B). Two different nematodicidal combinations of a macrocyclic lactone(ML) and a benzimidazole(BZD) anthelmintics were evaluated in a multi-resistant field scenario. Ivermectin(IVM)+ricobendazole(RBZ) both given subcutaneously and abamectin(ABA)+oxfendazole(OXF) both given orally were assessed in calves naturally infected with gastrointestinal nematodes resistant to both chemical families. The observed pharmacokinetic(PK) data demonstrated that the co-administration of two anthelmintics did not modify the plasma PK disposition of either drug in cattle. In fact, no adverse PK interactions were observed after each combined treatment, with no differences in PK parameters(P>0.05) observed between the single-drug and the combined-based strategies. While the observed initial efficacies were 40%(IVM), 64%(RBZ) and 90%(IVM+RBZ)(Farm A), the egg reductions were 54%(IVM), 84%(RBZ) and 98%(IVM-RBZ)(Farm B). After repeated annual(over 5 years) use of the same combination on both farms, the efficacy of the combined treatment decreased to 83% on Farm A. In contrast, the efficacy of the combination IVM-RBZ remained at 93% efficacy in Farm B .To optimize drug activity against those highly bi-resistant nematode population, oral combined treatments were assayed. Efficacies of ABA alone, OXF alone and the co-administration ABA+OXF were 62%, 88% and 99%, respectively(Farm A) and, 92%, 95% and 98%, respectively(Farm B).The Haemonchus spp. were resistant to ABA, the Ostertagia spp. were resistant to OXF and both anthelmintics failed to control the Cooperia spp.However, the combination ABA+OXF was the only treatment that achieved 99-100% efficacy against all genera, indicating the presence of an additive effect. Overall, anthelmintic combinations can be useful to optimize the control of resistant gastrointestinal nematodes of cattle.However, its rational use should be strongly supported by pre-treatment diagnosis and considering the epidemiological situation of each individual farm.
publishDate 2022
dc.date.none.fl_str_mv 2022
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http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/221440
Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations; 67º Annual Meeting American Association of Veterinary Parasitologists; Snowbird; Estados Unidos; 2022; 106-106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/221440
identifier_str_mv Combined anthelmintic treatments to control resistant nematodes in cattle: pharmacokinetic and field efficacy evaluations; 67º Annual Meeting American Association of Veterinary Parasitologists; Snowbird; Estados Unidos; 2022; 106-106
CONICET Digital
CONICET
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv American Association of Veterinary Parasitologists
publisher.none.fl_str_mv American Association of Veterinary Parasitologists
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