Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina

Autores
Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
Materia
ARBOVIRUS
FLAVIVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
BIOLOGICAL CHARACTERISATION
VIRULENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9236

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spelling Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in ArgentinaRivarola, María ElisaTauro, Laura BeatrizAlbrieu Llinás, GuillermoContigiani, Marta SilviaARBOVIRUSFLAVIVIRUSSAINT LOUIS ENCEPHALITIS VIRUSBIOLOGICAL CHARACTERISATIONVIRULENCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; ArgentinaFundacao Oswaldo Cruz2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9236Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-2010074-02761678-8060enginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?pid=S0074-02762014000200197&script=sci_arttextinfo:eu-repo/semantics/altIdentifier/doi/10.1590/0074-0276130475info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015247/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:58Zoai:ri.conicet.gov.ar:11336/9236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:58.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
title Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
spellingShingle Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
Rivarola, María Elisa
ARBOVIRUS
FLAVIVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
BIOLOGICAL CHARACTERISATION
VIRULENCE
title_short Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
title_full Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
title_fullStr Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
title_full_unstemmed Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
title_sort Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
dc.creator.none.fl_str_mv Rivarola, María Elisa
Tauro, Laura Beatriz
Albrieu Llinás, Guillermo
Contigiani, Marta Silvia
author Rivarola, María Elisa
author_facet Rivarola, María Elisa
Tauro, Laura Beatriz
Albrieu Llinás, Guillermo
Contigiani, Marta Silvia
author_role author
author2 Tauro, Laura Beatriz
Albrieu Llinás, Guillermo
Contigiani, Marta Silvia
author2_role author
author
author
dc.subject.none.fl_str_mv ARBOVIRUS
FLAVIVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
BIOLOGICAL CHARACTERISATION
VIRULENCE
topic ARBOVIRUS
FLAVIVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
BIOLOGICAL CHARACTERISATION
VIRULENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina
description Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9236
Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-201
0074-0276
1678-8060
url http://hdl.handle.net/11336/9236
identifier_str_mv Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-201
0074-0276
1678-8060
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?pid=S0074-02762014000200197&script=sci_arttext
info:eu-repo/semantics/altIdentifier/doi/10.1590/0074-0276130475
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015247/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Fundacao Oswaldo Cruz
publisher.none.fl_str_mv Fundacao Oswaldo Cruz
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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