Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina
- Autores
- Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina - Materia
-
ARBOVIRUS
FLAVIVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
BIOLOGICAL CHARACTERISATION
VIRULENCE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/9236
Ver los metadatos del registro completo
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Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in ArgentinaRivarola, María ElisaTauro, Laura BeatrizAlbrieu Llinás, GuillermoContigiani, Marta SilviaARBOVIRUSFLAVIVIRUSSAINT LOUIS ENCEPHALITIS VIRUSBIOLOGICAL CHARACTERISATIONVIRULENCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; ArgentinaFundacao Oswaldo Cruz2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9236Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-2010074-02761678-8060enginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?pid=S0074-02762014000200197&script=sci_arttextinfo:eu-repo/semantics/altIdentifier/doi/10.1590/0074-0276130475info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015247/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:58Zoai:ri.conicet.gov.ar:11336/9236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:58.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
title |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
spellingShingle |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina Rivarola, María Elisa ARBOVIRUS FLAVIVIRUS SAINT LOUIS ENCEPHALITIS VIRUS BIOLOGICAL CHARACTERISATION VIRULENCE |
title_short |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
title_full |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
title_fullStr |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
title_full_unstemmed |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
title_sort |
Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina |
dc.creator.none.fl_str_mv |
Rivarola, María Elisa Tauro, Laura Beatriz Albrieu Llinás, Guillermo Contigiani, Marta Silvia |
author |
Rivarola, María Elisa |
author_facet |
Rivarola, María Elisa Tauro, Laura Beatriz Albrieu Llinás, Guillermo Contigiani, Marta Silvia |
author_role |
author |
author2 |
Tauro, Laura Beatriz Albrieu Llinás, Guillermo Contigiani, Marta Silvia |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ARBOVIRUS FLAVIVIRUS SAINT LOUIS ENCEPHALITIS VIRUS BIOLOGICAL CHARACTERISATION VIRULENCE |
topic |
ARBOVIRUS FLAVIVIRUS SAINT LOUIS ENCEPHALITIS VIRUS BIOLOGICAL CHARACTERISATION VIRULENCE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases. Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tauro, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología; Argentina |
description |
Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr- 4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/9236 Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-201 0074-0276 1678-8060 |
url |
http://hdl.handle.net/11336/9236 |
identifier_str_mv |
Rivarola, María Elisa; Tauro, Laura Beatriz; Albrieu Llinás, Guillermo; Contigiani, Marta Silvia; Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 109; 2; 4-2014; 197-201 0074-0276 1678-8060 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?pid=S0074-02762014000200197&script=sci_arttext info:eu-repo/semantics/altIdentifier/doi/10.1590/0074-0276130475 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015247/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Fundacao Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundacao Oswaldo Cruz |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |