Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina

Autores
Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; Konigheim, Brenda Salome; Contigiani de Minio, Marta Silvia; Gruppi, Adriana
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
Materia
APOPTOSIS
ENCEPHALITIS
NEURODEGENERATION
NEUROTROPIC ARBOVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88168

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network_name_str CONICET Digital (CONICET)
spelling Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in ArgentinaRivarola, María Elisade Olmos, SoledadAlbrieu Llinás, GuillermoTauro, Laura BeatrizGorosito Serran, MelisaKonigheim, Brenda SalomeContigiani de Minio, Marta SilviaGruppi, AdrianaAPOPTOSISENCEPHALITISNEURODEGENERATIONNEUROTROPIC ARBOVIRUSSAINT LOUIS ENCEPHALITIS VIRUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; ArgentinaFil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; ArgentinaFil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; ArgentinaFil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; ArgentinaFrontiers Research Foundation2018-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88168Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-11811664-302XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2018.01181/fullinfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fmicb.2018.01181info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29930541info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:15Zoai:ri.conicet.gov.ar:11336/88168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:15.393CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
title Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
spellingShingle Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
Rivarola, María Elisa
APOPTOSIS
ENCEPHALITIS
NEURODEGENERATION
NEUROTROPIC ARBOVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
title_short Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
title_full Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
title_fullStr Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
title_full_unstemmed Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
title_sort Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
dc.creator.none.fl_str_mv Rivarola, María Elisa
de Olmos, Soledad
Albrieu Llinás, Guillermo
Tauro, Laura Beatriz
Gorosito Serran, Melisa
Konigheim, Brenda Salome
Contigiani de Minio, Marta Silvia
Gruppi, Adriana
author Rivarola, María Elisa
author_facet Rivarola, María Elisa
de Olmos, Soledad
Albrieu Llinás, Guillermo
Tauro, Laura Beatriz
Gorosito Serran, Melisa
Konigheim, Brenda Salome
Contigiani de Minio, Marta Silvia
Gruppi, Adriana
author_role author
author2 de Olmos, Soledad
Albrieu Llinás, Guillermo
Tauro, Laura Beatriz
Gorosito Serran, Melisa
Konigheim, Brenda Salome
Contigiani de Minio, Marta Silvia
Gruppi, Adriana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
ENCEPHALITIS
NEURODEGENERATION
NEUROTROPIC ARBOVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
topic APOPTOSIS
ENCEPHALITIS
NEURODEGENERATION
NEUROTROPIC ARBOVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
description Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88168
Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-1181
1664-302X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88168
identifier_str_mv Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-1181
1664-302X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fmicb.2018.01181
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29930541
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
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application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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