Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina
- Autores
- Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; Konigheim, Brenda Salome; Contigiani de Minio, Marta Silvia; Gruppi, Adriana
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.
Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina - Materia
-
APOPTOSIS
ENCEPHALITIS
NEURODEGENERATION
NEUROTROPIC ARBOVIRUS
SAINT LOUIS ENCEPHALITIS VIRUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/88168
Ver los metadatos del registro completo
id |
CONICETDig_c11203ca8028a1fd115475a0b187c309 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/88168 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in ArgentinaRivarola, María Elisade Olmos, SoledadAlbrieu Llinás, GuillermoTauro, Laura BeatrizGorosito Serran, MelisaKonigheim, Brenda SalomeContigiani de Minio, Marta SilviaGruppi, AdrianaAPOPTOSISENCEPHALITISNEURODEGENERATIONNEUROTROPIC ARBOVIRUSSAINT LOUIS ENCEPHALITIS VIRUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection.Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; ArgentinaFil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; ArgentinaFil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; ArgentinaFil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; ArgentinaFrontiers Research Foundation2018-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88168Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-11811664-302XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2018.01181/fullinfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fmicb.2018.01181info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29930541info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:15Zoai:ri.conicet.gov.ar:11336/88168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:15.393CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
title |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
spellingShingle |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina Rivarola, María Elisa APOPTOSIS ENCEPHALITIS NEURODEGENERATION NEUROTROPIC ARBOVIRUS SAINT LOUIS ENCEPHALITIS VIRUS |
title_short |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
title_full |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
title_fullStr |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
title_full_unstemmed |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
title_sort |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina |
dc.creator.none.fl_str_mv |
Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatriz Gorosito Serran, Melisa Konigheim, Brenda Salome Contigiani de Minio, Marta Silvia Gruppi, Adriana |
author |
Rivarola, María Elisa |
author_facet |
Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatriz Gorosito Serran, Melisa Konigheim, Brenda Salome Contigiani de Minio, Marta Silvia Gruppi, Adriana |
author_role |
author |
author2 |
de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatriz Gorosito Serran, Melisa Konigheim, Brenda Salome Contigiani de Minio, Marta Silvia Gruppi, Adriana |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
APOPTOSIS ENCEPHALITIS NEURODEGENERATION NEUROTROPIC ARBOVIRUS SAINT LOUIS ENCEPHALITIS VIRUS |
topic |
APOPTOSIS ENCEPHALITIS NEURODEGENERATION NEUROTROPIC ARBOVIRUS SAINT LOUIS ENCEPHALITIS VIRUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection. Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Albrieu Llinás, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina Fil: Tauro, Laura Beatriz. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gorosito Serran, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Laboratorio de Arbovirus y Arenovirus; Argentina Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina |
description |
Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/88168 Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-1181 1664-302X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/88168 |
identifier_str_mv |
Rivarola, María Elisa; de Olmos, Soledad; Albrieu Llinás, Guillermo; Tauro, Laura Beatriz; Gorosito Serran, Melisa; et al.; Neuronal degeneration in mice induced by an epidemic strain of Saint Louis encephalitis virus isolated in Argentina; Frontiers Research Foundation; Frontiers in Microbiology; 9; 7-6-2018; 1181-1181 1664-302X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2018.01181/full info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fmicb.2018.01181 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29930541 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Research Foundation |
publisher.none.fl_str_mv |
Frontiers Research Foundation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613392564748288 |
score |
13.070432 |