Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains

Autores
Diaz, Luis Adrian; Goñi, Sandra Elizabeth; Iserte, Javier Alonso; Quaglia, Agustín Ignacio Eugenio; Singh, Amber; Logue, Cristopher H.; Powers, Ann M.; Contigiani de Minio, Marta Silvia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina. The reason for the outbreak remains unknown, but may have been related to virological factors, changes in vectors populations, avian amplifying hosts, and/or environmental conditions. The main goal of this study was to characterize the complete genome of epidemic and non-epidemic SLEV strains from Argentina. Seventeen amino acid changes were detected; ten were non-conservative and located in proteins E, NS1, NS3 and NS5. Phylogenetic analysis showed two major clades based on geography: the North America and northern Central America (NAnCA) clade and the South America and southern Central America (SAsCA) clade. Interestingly, the presence of SAsCA genotype V SLEV strains in the NAnCA clade was reported in California, Florida and Texas, overlapping with known bird migration flyways. This work represents the first step in understanding the molecular mechanisms underlying virulence and biological variation among SLEV strains.
Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Goñi, Sandra Elizabeth. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina
Fil: Iserte, Javier Alonso. Fundación Instituto Leloir, Laboratorio de Bioinformática Estructural; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Quaglia, Agustín Ignacio Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Singh, Amber. Centers For Diseases Control And Prevention; Estados Unidos
Fil: Logue, Cristopher H.. Novel And Dangerous Pathogens Training; Reino Unido
Fil: Powers, Ann M.. Centers For Diseases Control And Prevention; Estados Unidos
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Materia
ST. LOUIS ENCEPHALITIS VIRUS
FLAVIVIRUS
ARBOVIRUS
EPIDEMIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40515
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/40515
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) StrainsDiaz, Luis AdrianGoñi, Sandra ElizabethIserte, Javier AlonsoQuaglia, Agustín Ignacio EugenioSingh, AmberLogue, Cristopher H.Powers, Ann M.Contigiani de Minio, Marta SilviaST. LOUIS ENCEPHALITIS VIRUSFLAVIVIRUSARBOVIRUSEPIDEMIChttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina. The reason for the outbreak remains unknown, but may have been related to virological factors, changes in vectors populations, avian amplifying hosts, and/or environmental conditions. The main goal of this study was to characterize the complete genome of epidemic and non-epidemic SLEV strains from Argentina. Seventeen amino acid changes were detected; ten were non-conservative and located in proteins E, NS1, NS3 and NS5. Phylogenetic analysis showed two major clades based on geography: the North America and northern Central America (NAnCA) clade and the South America and southern Central America (SAsCA) clade. Interestingly, the presence of SAsCA genotype V SLEV strains in the NAnCA clade was reported in California, Florida and Texas, overlapping with known bird migration flyways. This work represents the first step in understanding the molecular mechanisms underlying virulence and biological variation among SLEV strains.Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Goñi, Sandra Elizabeth. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; ArgentinaFil: Iserte, Javier Alonso. Fundación Instituto Leloir, Laboratorio de Bioinformática Estructural; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Quaglia, Agustín Ignacio Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Singh, Amber. Centers For Diseases Control And Prevention; Estados UnidosFil: Logue, Cristopher H.. Novel And Dangerous Pathogens Training; Reino UnidoFil: Powers, Ann M.. Centers For Diseases Control And Prevention; Estados UnidosFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaPublic Library of Science2015-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40515Diaz, Luis Adrian; Goñi, Sandra Elizabeth; Iserte, Javier Alonso; Quaglia, Agustín Ignacio Eugenio; Singh, Amber; et al.; Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains; Public Library of Science; Plos One; 10; 8; 27-8-2015; 1-161932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136316info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0136316info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:32:39Zoai:ri.conicet.gov.ar:11336/40515instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:32:40.222CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
title Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
spellingShingle Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
Diaz, Luis Adrian
ST. LOUIS ENCEPHALITIS VIRUS
FLAVIVIRUS
ARBOVIRUS
EPIDEMIC
title_short Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
title_full Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
title_fullStr Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
title_full_unstemmed Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
title_sort Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains
dc.creator.none.fl_str_mv Diaz, Luis Adrian
Goñi, Sandra Elizabeth
Iserte, Javier Alonso
Quaglia, Agustín Ignacio Eugenio
Singh, Amber
Logue, Cristopher H.
Powers, Ann M.
Contigiani de Minio, Marta Silvia
author Diaz, Luis Adrian
author_facet Diaz, Luis Adrian
Goñi, Sandra Elizabeth
Iserte, Javier Alonso
Quaglia, Agustín Ignacio Eugenio
Singh, Amber
Logue, Cristopher H.
Powers, Ann M.
Contigiani de Minio, Marta Silvia
author_role author
author2 Goñi, Sandra Elizabeth
Iserte, Javier Alonso
Quaglia, Agustín Ignacio Eugenio
Singh, Amber
Logue, Cristopher H.
Powers, Ann M.
Contigiani de Minio, Marta Silvia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ST. LOUIS ENCEPHALITIS VIRUS
FLAVIVIRUS
ARBOVIRUS
EPIDEMIC
topic ST. LOUIS ENCEPHALITIS VIRUS
FLAVIVIRUS
ARBOVIRUS
EPIDEMIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina. The reason for the outbreak remains unknown, but may have been related to virological factors, changes in vectors populations, avian amplifying hosts, and/or environmental conditions. The main goal of this study was to characterize the complete genome of epidemic and non-epidemic SLEV strains from Argentina. Seventeen amino acid changes were detected; ten were non-conservative and located in proteins E, NS1, NS3 and NS5. Phylogenetic analysis showed two major clades based on geography: the North America and northern Central America (NAnCA) clade and the South America and southern Central America (SAsCA) clade. Interestingly, the presence of SAsCA genotype V SLEV strains in the NAnCA clade was reported in California, Florida and Texas, overlapping with known bird migration flyways. This work represents the first step in understanding the molecular mechanisms underlying virulence and biological variation among SLEV strains.
Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Goñi, Sandra Elizabeth. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina
Fil: Iserte, Javier Alonso. Fundación Instituto Leloir, Laboratorio de Bioinformática Estructural; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Quaglia, Agustín Ignacio Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Singh, Amber. Centers For Diseases Control And Prevention; Estados Unidos
Fil: Logue, Cristopher H.. Novel And Dangerous Pathogens Training; Reino Unido
Fil: Powers, Ann M.. Centers For Diseases Control And Prevention; Estados Unidos
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
description St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina. The reason for the outbreak remains unknown, but may have been related to virological factors, changes in vectors populations, avian amplifying hosts, and/or environmental conditions. The main goal of this study was to characterize the complete genome of epidemic and non-epidemic SLEV strains from Argentina. Seventeen amino acid changes were detected; ten were non-conservative and located in proteins E, NS1, NS3 and NS5. Phylogenetic analysis showed two major clades based on geography: the North America and northern Central America (NAnCA) clade and the South America and southern Central America (SAsCA) clade. Interestingly, the presence of SAsCA genotype V SLEV strains in the NAnCA clade was reported in California, Florida and Texas, overlapping with known bird migration flyways. This work represents the first step in understanding the molecular mechanisms underlying virulence and biological variation among SLEV strains.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-27
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40515
Diaz, Luis Adrian; Goñi, Sandra Elizabeth; Iserte, Javier Alonso; Quaglia, Agustín Ignacio Eugenio; Singh, Amber; et al.; Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains; Public Library of Science; Plos One; 10; 8; 27-8-2015; 1-16
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40515
identifier_str_mv Diaz, Luis Adrian; Goñi, Sandra Elizabeth; Iserte, Javier Alonso; Quaglia, Agustín Ignacio Eugenio; Singh, Amber; et al.; Exploring genomic, geographic and virulence interactions among epidemic and non-epidemic St. Louis Encephalitis Virus (Flavivirus) Strains; Public Library of Science; Plos One; 10; 8; 27-8-2015; 1-16
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136316
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0136316
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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