Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius

Autores
Cáceres, Mariano; Guzmán, Eduardo; Alvarez Costa, Agustin; Ortega, Francisco; Rubio, Ramón G.; Coviella, Carlos Eduardo; Santo Orihuela, Pablo Luis; Vassena, Claudia Viviana; Lucia, Alejandro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Synthetic insecticides have been used for a long time as one of the most effective tools for insect pest control. However, the re-emergence of insect pests and their fast development of resistance, as has occurred for pyrethroid-resistant bed bugs Cimex lectularius L., make it necessary to develop new and safe strategies for effective pest control. This has fostered the research on new eco-sustainable formulations based on essential oils, which allows reducing the impact associated with the intensive use of synthetic insecticides on the environment and their effects on human health. This research explores the stability of water/eugenol/ethanol surfactantless emulsions loaded with imidacloprid (0.003 wt%), and their toxicity against a resistant bed bug strain. The results have shown that these emulsions enable the solubilization of a poorly water-soluble drug, such as the imidacloprid, without any significant modification of their stability. Furthermore, the application of the obtained formulations against the pyrethroid-resistant bed bug results in mortality in the 50–85% range upon topical and spray applications, with the increase of the eugenol content enhancing the effectiveness of the formulations. It may be expected that the ternary water/eugenol/ethanol mixtures could be further developed in the preparation of ready to use formulations, enabling the dispersion of insecticides for pest control.
Fil: Cáceres, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid; España
Fil: Alvarez Costa, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid; España
Fil: Coviella, Carlos Eduardo. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de Luján; Argentina
Fil: Santo Orihuela, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina
Fil: Vassena, Claudia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Universidad Nacional de San Martín. Instituto de Investigaciones en Ingeniería Ambiental. Centro de Estudios Ambientales; Argentina
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; Argentina
Materia
BED BUGS
EUGENOL
IMIDACLOPRID
SURFACTANTLESS EMULSIONS
TERNARY MIXTURES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117794
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/117794
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectulariusCáceres, MarianoGuzmán, EduardoAlvarez Costa, AgustinOrtega, FranciscoRubio, Ramón G.Coviella, Carlos EduardoSanto Orihuela, Pablo LuisVassena, Claudia VivianaLucia, AlejandroBED BUGSEUGENOLIMIDACLOPRIDSURFACTANTLESS EMULSIONSTERNARY MIXTUREShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Synthetic insecticides have been used for a long time as one of the most effective tools for insect pest control. However, the re-emergence of insect pests and their fast development of resistance, as has occurred for pyrethroid-resistant bed bugs Cimex lectularius L., make it necessary to develop new and safe strategies for effective pest control. This has fostered the research on new eco-sustainable formulations based on essential oils, which allows reducing the impact associated with the intensive use of synthetic insecticides on the environment and their effects on human health. This research explores the stability of water/eugenol/ethanol surfactantless emulsions loaded with imidacloprid (0.003 wt%), and their toxicity against a resistant bed bug strain. The results have shown that these emulsions enable the solubilization of a poorly water-soluble drug, such as the imidacloprid, without any significant modification of their stability. Furthermore, the application of the obtained formulations against the pyrethroid-resistant bed bug results in mortality in the 50–85% range upon topical and spray applications, with the increase of the eugenol content enhancing the effectiveness of the formulations. It may be expected that the ternary water/eugenol/ethanol mixtures could be further developed in the preparation of ready to use formulations, enabling the dispersion of insecticides for pest control.Fil: Cáceres, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; ArgentinaFil: Guzmán, Eduardo. Universidad Complutense de Madrid; EspañaFil: Alvarez Costa, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Ortega, Francisco. Universidad Complutense de Madrid; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid; EspañaFil: Coviella, Carlos Eduardo. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de Luján; ArgentinaFil: Santo Orihuela, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; ArgentinaFil: Vassena, Claudia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Universidad Nacional de San Martín. Instituto de Investigaciones en Ingeniería Ambiental. Centro de Estudios Ambientales; ArgentinaFil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; ArgentinaMolecular Diversity Preservation International2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117794Cáceres, Mariano; Guzmán, Eduardo; Alvarez Costa, Agustin; Ortega, Francisco; Rubio, Ramón G.; et al.; Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius; Molecular Diversity Preservation International; Molecules; 25; 10; 5-2020; 1-171420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/10/2290info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25102290info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:46:12Zoai:ri.conicet.gov.ar:11336/117794instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:46:12.443CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
title Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
spellingShingle Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
Cáceres, Mariano
BED BUGS
EUGENOL
IMIDACLOPRID
SURFACTANTLESS EMULSIONS
TERNARY MIXTURES
title_short Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
title_full Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
title_fullStr Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
title_full_unstemmed Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
title_sort Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius
dc.creator.none.fl_str_mv Cáceres, Mariano
Guzmán, Eduardo
Alvarez Costa, Agustin
Ortega, Francisco
Rubio, Ramón G.
Coviella, Carlos Eduardo
Santo Orihuela, Pablo Luis
Vassena, Claudia Viviana
Lucia, Alejandro
author Cáceres, Mariano
author_facet Cáceres, Mariano
Guzmán, Eduardo
Alvarez Costa, Agustin
Ortega, Francisco
Rubio, Ramón G.
Coviella, Carlos Eduardo
Santo Orihuela, Pablo Luis
Vassena, Claudia Viviana
Lucia, Alejandro
author_role author
author2 Guzmán, Eduardo
Alvarez Costa, Agustin
Ortega, Francisco
Rubio, Ramón G.
Coviella, Carlos Eduardo
Santo Orihuela, Pablo Luis
Vassena, Claudia Viviana
Lucia, Alejandro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BED BUGS
EUGENOL
IMIDACLOPRID
SURFACTANTLESS EMULSIONS
TERNARY MIXTURES
topic BED BUGS
EUGENOL
IMIDACLOPRID
SURFACTANTLESS EMULSIONS
TERNARY MIXTURES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Synthetic insecticides have been used for a long time as one of the most effective tools for insect pest control. However, the re-emergence of insect pests and their fast development of resistance, as has occurred for pyrethroid-resistant bed bugs Cimex lectularius L., make it necessary to develop new and safe strategies for effective pest control. This has fostered the research on new eco-sustainable formulations based on essential oils, which allows reducing the impact associated with the intensive use of synthetic insecticides on the environment and their effects on human health. This research explores the stability of water/eugenol/ethanol surfactantless emulsions loaded with imidacloprid (0.003 wt%), and their toxicity against a resistant bed bug strain. The results have shown that these emulsions enable the solubilization of a poorly water-soluble drug, such as the imidacloprid, without any significant modification of their stability. Furthermore, the application of the obtained formulations against the pyrethroid-resistant bed bug results in mortality in the 50–85% range upon topical and spray applications, with the increase of the eugenol content enhancing the effectiveness of the formulations. It may be expected that the ternary water/eugenol/ethanol mixtures could be further developed in the preparation of ready to use formulations, enabling the dispersion of insecticides for pest control.
Fil: Cáceres, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid; España
Fil: Alvarez Costa, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid; España
Fil: Coviella, Carlos Eduardo. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de Luján; Argentina
Fil: Santo Orihuela, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina
Fil: Vassena, Claudia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Universidad Nacional de San Martín. Instituto de Investigaciones en Ingeniería Ambiental. Centro de Estudios Ambientales; Argentina
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; Argentina
description Synthetic insecticides have been used for a long time as one of the most effective tools for insect pest control. However, the re-emergence of insect pests and their fast development of resistance, as has occurred for pyrethroid-resistant bed bugs Cimex lectularius L., make it necessary to develop new and safe strategies for effective pest control. This has fostered the research on new eco-sustainable formulations based on essential oils, which allows reducing the impact associated with the intensive use of synthetic insecticides on the environment and their effects on human health. This research explores the stability of water/eugenol/ethanol surfactantless emulsions loaded with imidacloprid (0.003 wt%), and their toxicity against a resistant bed bug strain. The results have shown that these emulsions enable the solubilization of a poorly water-soluble drug, such as the imidacloprid, without any significant modification of their stability. Furthermore, the application of the obtained formulations against the pyrethroid-resistant bed bug results in mortality in the 50–85% range upon topical and spray applications, with the increase of the eugenol content enhancing the effectiveness of the formulations. It may be expected that the ternary water/eugenol/ethanol mixtures could be further developed in the preparation of ready to use formulations, enabling the dispersion of insecticides for pest control.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117794
Cáceres, Mariano; Guzmán, Eduardo; Alvarez Costa, Agustin; Ortega, Francisco; Rubio, Ramón G.; et al.; Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius; Molecular Diversity Preservation International; Molecules; 25; 10; 5-2020; 1-17
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117794
identifier_str_mv Cáceres, Mariano; Guzmán, Eduardo; Alvarez Costa, Agustin; Ortega, Francisco; Rubio, Ramón G.; et al.; Surfactantless emulsions containing eugenol for imidacloprid solubilization: Physicochemical characterization and toxicity against insecticide-resistant cimex lectularius; Molecular Diversity Preservation International; Molecules; 25; 10; 5-2020; 1-17
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/10/2290
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25102290
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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