Intra-cluster percolation of calcium signals

Autores
Solovey, G.; Dawson, S.P.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson.
Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
PLoS ONE 2010;5(2)
Materia
calcium channel
calcium ion
inositol 1,4,5 trisphosphate receptor
calcium
calcium channel
inositol 1,4,5 trisphosphate
inositol 1,4,5 trisphosphate receptor
article
binding competition
calcium signaling
cluster analysis
molecular interaction
Poisson distribution
protein analysis
protein protein interaction
statistical analysis
stochastic model
algorithm
animal
biological model
human
metabolism
physiology
statistics
Neptunia
Algorithms
Animals
Calcium
Calcium Channels
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Stochastic Processes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_19326203_v5_n2_p_Solovey

id BDUBAFCEN_1b868a76a5f81ed16efeec45f6539521
oai_identifier_str paperaa:paper_19326203_v5_n2_p_Solovey
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Intra-cluster percolation of calcium signalsSolovey, G.Dawson, S.P.calcium channelcalcium ioninositol 1,4,5 trisphosphate receptorcalciumcalcium channelinositol 1,4,5 trisphosphateinositol 1,4,5 trisphosphate receptorarticlebinding competitioncalcium signalingcluster analysismolecular interactionPoisson distributionprotein analysisprotein protein interactionstatistical analysisstochastic modelalgorithmanimalbiological modelhumanmetabolismphysiologystatisticsNeptuniaAlgorithmsAnimalsCalciumCalcium ChannelsCalcium SignalingHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsModels, BiologicalStochastic ProcessesCalcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson.Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_SoloveyPLoS ONE 2010;5(2)reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:05Zpaperaa:paper_19326203_v5_n2_p_SoloveyInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:07.24Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Intra-cluster percolation of calcium signals
title Intra-cluster percolation of calcium signals
spellingShingle Intra-cluster percolation of calcium signals
Solovey, G.
calcium channel
calcium ion
inositol 1,4,5 trisphosphate receptor
calcium
calcium channel
inositol 1,4,5 trisphosphate
inositol 1,4,5 trisphosphate receptor
article
binding competition
calcium signaling
cluster analysis
molecular interaction
Poisson distribution
protein analysis
protein protein interaction
statistical analysis
stochastic model
algorithm
animal
biological model
human
metabolism
physiology
statistics
Neptunia
Algorithms
Animals
Calcium
Calcium Channels
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Stochastic Processes
title_short Intra-cluster percolation of calcium signals
title_full Intra-cluster percolation of calcium signals
title_fullStr Intra-cluster percolation of calcium signals
title_full_unstemmed Intra-cluster percolation of calcium signals
title_sort Intra-cluster percolation of calcium signals
dc.creator.none.fl_str_mv Solovey, G.
Dawson, S.P.
author Solovey, G.
author_facet Solovey, G.
Dawson, S.P.
author_role author
author2 Dawson, S.P.
author2_role author
dc.subject.none.fl_str_mv calcium channel
calcium ion
inositol 1,4,5 trisphosphate receptor
calcium
calcium channel
inositol 1,4,5 trisphosphate
inositol 1,4,5 trisphosphate receptor
article
binding competition
calcium signaling
cluster analysis
molecular interaction
Poisson distribution
protein analysis
protein protein interaction
statistical analysis
stochastic model
algorithm
animal
biological model
human
metabolism
physiology
statistics
Neptunia
Algorithms
Animals
Calcium
Calcium Channels
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Stochastic Processes
topic calcium channel
calcium ion
inositol 1,4,5 trisphosphate receptor
calcium
calcium channel
inositol 1,4,5 trisphosphate
inositol 1,4,5 trisphosphate receptor
article
binding competition
calcium signaling
cluster analysis
molecular interaction
Poisson distribution
protein analysis
protein protein interaction
statistical analysis
stochastic model
algorithm
animal
biological model
human
metabolism
physiology
statistics
Neptunia
Algorithms
Animals
Calcium
Calcium Channels
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Stochastic Processes
dc.description.none.fl_txt_mv Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson.
Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Calcium signals are involved in a large variety of physiological processes. Their versatility relies on the diversity of spatiotemporal behaviors that the calcium concentration can display. Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R's) is a key component that participates in both local signals such as "puffs" and in global waves. IP3R's are usually organized in clusters on the membrane of the endoplasmic reticulum and their spatial distribution has important effects on the resulting signal. Recent high resolution observations [1] of Ca2+ puffs offer a window to study intra-cluster organization. The experiments give the distribution of the number of IP3R's that open during each puff without much processing. Here we present a simple model with which we interpret the experimental distribution in terms of two stochastic processes: IP3 binding and unbinding and Ca2+-mediated inter-channel coupling. Depending on the parameters of the system, the distribution may be dominated by one or the other process. The transition between both extreme cases is similar to a percolation process. We show how, from an analysis of the experimental distribution, information can be obtained on the relative weight of the two processes. The largest distance over which Ca2+mediated coupling acts and the density of IP3-bound IP3R's of the cluster can also be estimated. The approach allows us to infer properties of the interactions among the channels of the cluster from statistical information on their emergent collective behavior. © 2010 Solovey, Dawson.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_Solovey
url http://hdl.handle.net/20.500.12110/paper_19326203_v5_n2_p_Solovey
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv PLoS ONE 2010;5(2)
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
_version_ 1844618739418398720
score 13.070432