Observable effects of Ca2+ buffers on local Ca2+ signals
- Autores
- Solovey, G.; Dawson, S.P.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.
Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603
- Materia
-
Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_1364503X_v368_n1933_p5597_Solovey
Ver los metadatos del registro completo
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Observable effects of Ca2+ buffers on local Ca2+ signalsSolovey, G.Dawson, S.P.BuffersPuffsSugarsTransport propertiesBuffersHigh resolutionLocal signalOptical experimentsPhysiological processPuffsCalciumbuffercalciuminositol 1,4,5 trisphosphatealgorithmarticlebiological modelcalcium signalingcell membranechannel gatingchemistrycomputer simulationcytosoldose responseendoplasmic reticulumkineticsmetabolismphysiologyprobabilitystatistical modelAlgorithmsBuffersCalciumCalcium SignalingCell MembraneComputer SimulationCytosolDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateIon Channel GatingKineticsModels, BiologicalModels, StatisticalProbabilityCalcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_SoloveyPhilos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:00Zpaperaa:paper_1364503X_v368_n1933_p5597_SoloveyInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:01.934Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title |
Observable effects of Ca2+ buffers on local Ca2+ signals |
spellingShingle |
Observable effects of Ca2+ buffers on local Ca2+ signals Solovey, G. Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
title_short |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_full |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_fullStr |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_full_unstemmed |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_sort |
Observable effects of Ca2+ buffers on local Ca2+ signals |
dc.creator.none.fl_str_mv |
Solovey, G. Dawson, S.P. |
author |
Solovey, G. |
author_facet |
Solovey, G. Dawson, S.P. |
author_role |
author |
author2 |
Dawson, S.P. |
author2_role |
author |
dc.subject.none.fl_str_mv |
Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
topic |
Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
dc.description.none.fl_txt_mv |
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
url |
http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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13.070432 |