Observable effects of Ca2+ buffers on local Ca2+ signals

Autores
Solovey, G.; Dawson, S.P.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.
Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603
Materia
Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_1364503X_v368_n1933_p5597_Solovey
Acceder
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oai_identifier_str paperaa:paper_1364503X_v368_n1933_p5597_Solovey
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Observable effects of Ca2+ buffers on local Ca2+ signalsSolovey, G.Dawson, S.P.BuffersPuffsSugarsTransport propertiesBuffersHigh resolutionLocal signalOptical experimentsPhysiological processPuffsCalciumbuffercalciuminositol 1,4,5 trisphosphatealgorithmarticlebiological modelcalcium signalingcell membranechannel gatingchemistrycomputer simulationcytosoldose responseendoplasmic reticulumkineticsmetabolismphysiologyprobabilitystatistical modelAlgorithmsBuffersCalciumCalcium SignalingCell MembraneComputer SimulationCytosolDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateIon Channel GatingKineticsModels, BiologicalModels, StatisticalProbabilityCalcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_SoloveyPhilos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-10-16T09:30:10Zpaperaa:paper_1364503X_v368_n1933_p5597_SoloveyInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-10-16 09:30:12.063Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Observable effects of Ca2+ buffers on local Ca2+ signals
title Observable effects of Ca2+ buffers on local Ca2+ signals
spellingShingle Observable effects of Ca2+ buffers on local Ca2+ signals
Solovey, G.
Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
title_short Observable effects of Ca2+ buffers on local Ca2+ signals
title_full Observable effects of Ca2+ buffers on local Ca2+ signals
title_fullStr Observable effects of Ca2+ buffers on local Ca2+ signals
title_full_unstemmed Observable effects of Ca2+ buffers on local Ca2+ signals
title_sort Observable effects of Ca2+ buffers on local Ca2+ signals
dc.creator.none.fl_str_mv Solovey, G.
Dawson, S.P.
author Solovey, G.
author_facet Solovey, G.
Dawson, S.P.
author_role author
author2 Dawson, S.P.
author2_role author
dc.subject.none.fl_str_mv Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
topic Buffers
Puffs
Sugars
Transport properties
Buffers
High resolution
Local signal
Optical experiments
Physiological process
Puffs
Calcium
buffer
calcium
inositol 1,4,5 trisphosphate
algorithm
article
biological model
calcium signaling
cell membrane
channel gating
chemistry
computer simulation
cytosol
dose response
endoplasmic reticulum
kinetics
metabolism
physiology
probability
statistical model
Algorithms
Buffers
Calcium
Calcium Signaling
Cell Membrane
Computer Simulation
Cytosol
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
Ion Channel Gating
Kinetics
Models, Biological
Models, Statistical
Probability
dc.description.none.fl_txt_mv Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.
Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
url http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 12.712165

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