Poisson regression in mapping cancer mortality

Autores
Vacchino, Marta
Año de publicación
1999
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Vacchino, Marta N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
The aim of this study was to map standardized mortality ratios (SMRs) of specific cancers in Argentina and to examine some ecological relationships using Poisson regression, Poisson regression with frailties, and empirical Bayes estimates. Mortality data for lung cancer, nonmelanoma skin cancer, melanoma, and stomach cancer were obtained from national registers for the period 1989-1993. Overcrowding and unsatisfied basic needs (UBN) were used as indicators of socioeconomic status and people working permanently on farms as an indicator of rural activity. Empirical Bayes estimates provided a good solution for mapping rare causes of cancer when random fluctuations of observed deaths are important, as in the case of nonmelanoma skin cancer (NMSC) and melanoma. In the case of lung and stomach cancers the main improvement was the attenuation of confidence intervals. Lung cancer rates (males and females) were higher in jurisdictions with better socioeconomic status. When the variable UBN was categorized in tertiles (<20, 20-27, and 28% and higher) the rate ratios of lung cancer in men fell to 0.82 IC 95% (0. 78-0.85) in those with UNB index among 20-27% with respect to the reference level and to 0.56 IC 95% (0.54-0.59) in those with more than 28%. In contrast, stomach cancer rates were associated with worse economic conditions. NMSC and melanoma showed different patterns. The former was associated with working on farms, while the latter was not. Neither NMSC nor melanoma was increased in areas affected by Antarctica's ozone hole. Research appears to be warranted to further investigate associations of lung cancer with smoking and behavior in women living in southern Argentinean provinces. Public education must continue to promote personal responsibility in the intervention process to reduce the morbidity and mortality associated with cancers, such as lung and skin cancer, which are partially avoidable through behavioral changes.
Fuente
Environmental research 1999;81(1):1-17
Materia
Neoplasias Pulmonares
Neoplasias Cutáneas
Melanoma
Estudios Ecológicos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/2130

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spelling Poisson regression in mapping cancer mortalityVacchino, MartaNeoplasias PulmonaresNeoplasias CutáneasMelanomaEstudios EcológicosFil: Vacchino, Marta N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.The aim of this study was to map standardized mortality ratios (SMRs) of specific cancers in Argentina and to examine some ecological relationships using Poisson regression, Poisson regression with frailties, and empirical Bayes estimates. Mortality data for lung cancer, nonmelanoma skin cancer, melanoma, and stomach cancer were obtained from national registers for the period 1989-1993. Overcrowding and unsatisfied basic needs (UBN) were used as indicators of socioeconomic status and people working permanently on farms as an indicator of rural activity. Empirical Bayes estimates provided a good solution for mapping rare causes of cancer when random fluctuations of observed deaths are important, as in the case of nonmelanoma skin cancer (NMSC) and melanoma. In the case of lung and stomach cancers the main improvement was the attenuation of confidence intervals. Lung cancer rates (males and females) were higher in jurisdictions with better socioeconomic status. When the variable UBN was categorized in tertiles (<20, 20-27, and 28% and higher) the rate ratios of lung cancer in men fell to 0.82 IC 95% (0. 78-0.85) in those with UNB index among 20-27% with respect to the reference level and to 0.56 IC 95% (0.54-0.59) in those with more than 28%. In contrast, stomach cancer rates were associated with worse economic conditions. NMSC and melanoma showed different patterns. The former was associated with working on farms, while the latter was not. Neither NMSC nor melanoma was increased in areas affected by Antarctica's ozone hole. Research appears to be warranted to further investigate associations of lung cancer with smoking and behavior in women living in southern Argentinean provinces. Public education must continue to promote personal responsibility in the intervention process to reduce the morbidity and mortality associated with cancers, such as lung and skin cancer, which are partially avoidable through behavioral changes.1999-07info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0013-9351http://sgc.anlis.gob.ar/handle/123456789/213010.1006/enrs.1998.3953Environmental research 1999;81(1):1-17reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISEnvironmental researchnoneinfo:eu-repo/semantics/openAccesseng2025-09-04T11:18:15Zoai:sgc.anlis.gob.ar:123456789/2130Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:15.372Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Poisson regression in mapping cancer mortality
title Poisson regression in mapping cancer mortality
spellingShingle Poisson regression in mapping cancer mortality
Vacchino, Marta
Neoplasias Pulmonares
Neoplasias Cutáneas
Melanoma
Estudios Ecológicos
title_short Poisson regression in mapping cancer mortality
title_full Poisson regression in mapping cancer mortality
title_fullStr Poisson regression in mapping cancer mortality
title_full_unstemmed Poisson regression in mapping cancer mortality
title_sort Poisson regression in mapping cancer mortality
dc.creator.none.fl_str_mv Vacchino, Marta
author Vacchino, Marta
author_facet Vacchino, Marta
author_role author
dc.subject.none.fl_str_mv Neoplasias Pulmonares
Neoplasias Cutáneas
Melanoma
Estudios Ecológicos
topic Neoplasias Pulmonares
Neoplasias Cutáneas
Melanoma
Estudios Ecológicos
dc.description.none.fl_txt_mv Fil: Vacchino, Marta N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
The aim of this study was to map standardized mortality ratios (SMRs) of specific cancers in Argentina and to examine some ecological relationships using Poisson regression, Poisson regression with frailties, and empirical Bayes estimates. Mortality data for lung cancer, nonmelanoma skin cancer, melanoma, and stomach cancer were obtained from national registers for the period 1989-1993. Overcrowding and unsatisfied basic needs (UBN) were used as indicators of socioeconomic status and people working permanently on farms as an indicator of rural activity. Empirical Bayes estimates provided a good solution for mapping rare causes of cancer when random fluctuations of observed deaths are important, as in the case of nonmelanoma skin cancer (NMSC) and melanoma. In the case of lung and stomach cancers the main improvement was the attenuation of confidence intervals. Lung cancer rates (males and females) were higher in jurisdictions with better socioeconomic status. When the variable UBN was categorized in tertiles (<20, 20-27, and 28% and higher) the rate ratios of lung cancer in men fell to 0.82 IC 95% (0. 78-0.85) in those with UNB index among 20-27% with respect to the reference level and to 0.56 IC 95% (0.54-0.59) in those with more than 28%. In contrast, stomach cancer rates were associated with worse economic conditions. NMSC and melanoma showed different patterns. The former was associated with working on farms, while the latter was not. Neither NMSC nor melanoma was increased in areas affected by Antarctica's ozone hole. Research appears to be warranted to further investigate associations of lung cancer with smoking and behavior in women living in southern Argentinean provinces. Public education must continue to promote personal responsibility in the intervention process to reduce the morbidity and mortality associated with cancers, such as lung and skin cancer, which are partially avoidable through behavioral changes.
description Fil: Vacchino, Marta N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
publishDate 1999
dc.date.none.fl_str_mv 1999-07
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0013-9351
http://sgc.anlis.gob.ar/handle/123456789/2130
10.1006/enrs.1998.3953
identifier_str_mv 0013-9351
10.1006/enrs.1998.3953
url http://sgc.anlis.gob.ar/handle/123456789/2130
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Environmental research
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Environmental research 1999;81(1):1-17
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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