Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects

Autores
Cornejo, María Paula; Denis, Raphaël G. P.; García Romero, Guadalupe; Fernández, Gimena; Reynaldo, Mirta Beatriz; Luquet, Serge; Perelló, Mario Carlos
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found that ghrelin primarily induces a biphasic effect on food intake that has indirect consequences on energy expenditure and nutrient partitioning. We also found that ghrelin-induced biphasic effect on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons of the hypothalamic arcuate nucleus, which seem to display a long-lasting activation after a single systemic injection of ghrelin. Finally, we found that different autonomic, hormonal and metabolic satiation signals transiently counteract ghrelin-induced food intake. Based on our observations, we propose a heuristic model to describe how the orexigenic effect of ghrelin and the anorectic food intake-induced rebound sculpt a timely constrain feeding response to ghrelin.
Instituto Multidisciplinario de Biología Celular
Materia
Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/139526
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/139526
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effectsCornejo, María PaulaDenis, Raphaël G. P.García Romero, GuadalupeFernández, GimenaReynaldo, Mirta BeatrizLuquet, SergePerelló, Mario CarlosCiencias ExactasBiologíaGhrelinarcuateAgRPdelayed effectGhrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found that ghrelin primarily induces a biphasic effect on food intake that has indirect consequences on energy expenditure and nutrient partitioning. We also found that ghrelin-induced biphasic effect on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons of the hypothalamic arcuate nucleus, which seem to display a long-lasting activation after a single systemic injection of ghrelin. Finally, we found that different autonomic, hormonal and metabolic satiation signals transiently counteract ghrelin-induced food intake. Based on our observations, we propose a heuristic model to describe how the orexigenic effect of ghrelin and the anorectic food intake-induced rebound sculpt a timely constrain feeding response to ghrelin.Instituto Multidisciplinario de Biología Celular2021-09-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-20http://sedici.unlp.edu.ar/handle/10915/139526enginfo:eu-repo/semantics/altIdentifier/issn/1420-9071info:eu-repo/semantics/altIdentifier/issn/1420-682xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-021-03937-0info:eu-repo/semantics/altIdentifier/pmid/34559253info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:02Zoai:sedici.unlp.edu.ar:10915/139526Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:02.505SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
spellingShingle Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
Cornejo, María Paula
Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
title_short Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_full Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_fullStr Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_full_unstemmed Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
title_sort Ghrelin treatment induces rapid and delayed increments of food intake : A heuristic model to explain ghrelin's orexigenic effects
dc.creator.none.fl_str_mv Cornejo, María Paula
Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
author Cornejo, María Paula
author_facet Cornejo, María Paula
Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
author_role author
author2 Denis, Raphaël G. P.
García Romero, Guadalupe
Fernández, Gimena
Reynaldo, Mirta Beatriz
Luquet, Serge
Perelló, Mario Carlos
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
topic Ciencias Exactas
Biología
Ghrelin
arcuate
AgRP
delayed effect
dc.description.none.fl_txt_mv Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found that ghrelin primarily induces a biphasic effect on food intake that has indirect consequences on energy expenditure and nutrient partitioning. We also found that ghrelin-induced biphasic effect on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons of the hypothalamic arcuate nucleus, which seem to display a long-lasting activation after a single systemic injection of ghrelin. Finally, we found that different autonomic, hormonal and metabolic satiation signals transiently counteract ghrelin-induced food intake. Based on our observations, we propose a heuristic model to describe how the orexigenic effect of ghrelin and the anorectic food intake-induced rebound sculpt a timely constrain feeding response to ghrelin.
Instituto Multidisciplinario de Biología Celular
description Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance and metabolism. Notably, ghrelin is recognized as the most powerful known circulating orexigenic hormone. Here, we systematically investigated the effects of ghrelin on energy homeostasis and found that ghrelin primarily induces a biphasic effect on food intake that has indirect consequences on energy expenditure and nutrient partitioning. We also found that ghrelin-induced biphasic effect on food intake requires the integrity of Agouti-related peptide/neuropeptide Y-producing neurons of the hypothalamic arcuate nucleus, which seem to display a long-lasting activation after a single systemic injection of ghrelin. Finally, we found that different autonomic, hormonal and metabolic satiation signals transiently counteract ghrelin-induced food intake. Based on our observations, we propose a heuristic model to describe how the orexigenic effect of ghrelin and the anorectic food intake-induced rebound sculpt a timely constrain feeding response to ghrelin.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/139526
url http://sedici.unlp.edu.ar/handle/10915/139526
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1420-9071
info:eu-repo/semantics/altIdentifier/issn/1420-682x
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-021-03937-0
info:eu-repo/semantics/altIdentifier/pmid/34559253
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1-20
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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