Importance of nephron number in the regulation of arterial pressure and renal function during ageing

Autores
Reverte, Virginia; Loria, Analía; Sáez, Fara; Salazar, Francisco; Llinas, M. Teresa; Javier Salazar, F.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The physiological importance of the kidneys in the long-term control of extracellular volume and arterial pressure has been demonstrated in studies showing that an alteration of renal function leads to the development of hypertension and other cardiovascular dysfunctions (1-4). It has also been proposed that the development of hypertension may be secondary to an altered nephron endowment during the nephrogenic period (3,4). A cause-effect link between nephron number at birth and hypertension has been proposed in clinical and experimental studies showing that essential hypertensive patients have a reduced nephron number (3-6), and that the alteration of nephrogenesis leads to the development of hypertension during the adult life (3,4,7-10). A deficient nephrogenesis has been observed in offspring of pregnant mothers taking a low protein diet, or treated with either corticoids or a cyclooxygenase-2 (COX-2) inhibitor (3,4). The renin-angiotensin system (RAS) seems to play an important role in the regulation of nephrogenesis because its activity is reduced in these situations (3,4), and it is known that angiotensin II (Ang II) is involved in regulating renal growth and differentiation (11). The role of Ang II in renal development has been confirmed in studies demonstrating an elevation of all RAS components during the nephrogenic period and showing that the administration of either a converting enzyme inhibitor or an Ang II AT1 receptor antagonist during this period leads to a significant reduction in nephron number and an alteration of the normal kidney structure (7,8).
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
Presión arterial
Hipertensión
Fisiología
Riñones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/148574

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network_name_str SEDICI (UNLP)
spelling Importance of nephron number in the regulation of arterial pressure and renal function during ageingReverte, VirginiaLoria, AnalíaSáez, FaraSalazar, FranciscoLlinas, M. TeresaJavier Salazar, F.Ciencias MédicasPresión arterialHipertensiónFisiologíaRiñonesThe physiological importance of the kidneys in the long-term control of extracellular volume and arterial pressure has been demonstrated in studies showing that an alteration of renal function leads to the development of hypertension and other cardiovascular dysfunctions (1-4). It has also been proposed that the development of hypertension may be secondary to an altered nephron endowment during the nephrogenic period (3,4). A cause-effect link between nephron number at birth and hypertension has been proposed in clinical and experimental studies showing that essential hypertensive patients have a reduced nephron number (3-6), and that the alteration of nephrogenesis leads to the development of hypertension during the adult life (3,4,7-10). A deficient nephrogenesis has been observed in offspring of pregnant mothers taking a low protein diet, or treated with either corticoids or a cyclooxygenase-2 (COX-2) inhibitor (3,4). The renin-angiotensin system (RAS) seems to play an important role in the regulation of nephrogenesis because its activity is reduced in these situations (3,4), and it is known that angiotensin II (Ang II) is involved in regulating renal growth and differentiation (11). The role of Ang II in renal development has been confirmed in studies demonstrating an elevation of all RAS components during the nephrogenic period and showing that the administration of either a converting enzyme inhibitor or an Ang II AT1 receptor antagonist during this period leads to a significant reduction in nephron number and an alteration of the normal kidney structure (7,8).Sociedad Argentina de Fisiología2008-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf17-24http://sedici.unlp.edu.ar/handle/10915/148574enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/issue/importance-of-nephron-number-in-the-regulation-of-arterial-pressure-and-renal-function-during-ageing/info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:10:08Zoai:sedici.unlp.edu.ar:10915/148574Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:10:09.13SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Importance of nephron number in the regulation of arterial pressure and renal function during ageing
title Importance of nephron number in the regulation of arterial pressure and renal function during ageing
spellingShingle Importance of nephron number in the regulation of arterial pressure and renal function during ageing
Reverte, Virginia
Ciencias Médicas
Presión arterial
Hipertensión
Fisiología
Riñones
title_short Importance of nephron number in the regulation of arterial pressure and renal function during ageing
title_full Importance of nephron number in the regulation of arterial pressure and renal function during ageing
title_fullStr Importance of nephron number in the regulation of arterial pressure and renal function during ageing
title_full_unstemmed Importance of nephron number in the regulation of arterial pressure and renal function during ageing
title_sort Importance of nephron number in the regulation of arterial pressure and renal function during ageing
dc.creator.none.fl_str_mv Reverte, Virginia
Loria, Analía
Sáez, Fara
Salazar, Francisco
Llinas, M. Teresa
Javier Salazar, F.
author Reverte, Virginia
author_facet Reverte, Virginia
Loria, Analía
Sáez, Fara
Salazar, Francisco
Llinas, M. Teresa
Javier Salazar, F.
author_role author
author2 Loria, Analía
Sáez, Fara
Salazar, Francisco
Llinas, M. Teresa
Javier Salazar, F.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Presión arterial
Hipertensión
Fisiología
Riñones
topic Ciencias Médicas
Presión arterial
Hipertensión
Fisiología
Riñones
dc.description.none.fl_txt_mv The physiological importance of the kidneys in the long-term control of extracellular volume and arterial pressure has been demonstrated in studies showing that an alteration of renal function leads to the development of hypertension and other cardiovascular dysfunctions (1-4). It has also been proposed that the development of hypertension may be secondary to an altered nephron endowment during the nephrogenic period (3,4). A cause-effect link between nephron number at birth and hypertension has been proposed in clinical and experimental studies showing that essential hypertensive patients have a reduced nephron number (3-6), and that the alteration of nephrogenesis leads to the development of hypertension during the adult life (3,4,7-10). A deficient nephrogenesis has been observed in offspring of pregnant mothers taking a low protein diet, or treated with either corticoids or a cyclooxygenase-2 (COX-2) inhibitor (3,4). The renin-angiotensin system (RAS) seems to play an important role in the regulation of nephrogenesis because its activity is reduced in these situations (3,4), and it is known that angiotensin II (Ang II) is involved in regulating renal growth and differentiation (11). The role of Ang II in renal development has been confirmed in studies demonstrating an elevation of all RAS components during the nephrogenic period and showing that the administration of either a converting enzyme inhibitor or an Ang II AT1 receptor antagonist during this period leads to a significant reduction in nephron number and an alteration of the normal kidney structure (7,8).
Sociedad Argentina de Fisiología
description The physiological importance of the kidneys in the long-term control of extracellular volume and arterial pressure has been demonstrated in studies showing that an alteration of renal function leads to the development of hypertension and other cardiovascular dysfunctions (1-4). It has also been proposed that the development of hypertension may be secondary to an altered nephron endowment during the nephrogenic period (3,4). A cause-effect link between nephron number at birth and hypertension has been proposed in clinical and experimental studies showing that essential hypertensive patients have a reduced nephron number (3-6), and that the alteration of nephrogenesis leads to the development of hypertension during the adult life (3,4,7-10). A deficient nephrogenesis has been observed in offspring of pregnant mothers taking a low protein diet, or treated with either corticoids or a cyclooxygenase-2 (COX-2) inhibitor (3,4). The renin-angiotensin system (RAS) seems to play an important role in the regulation of nephrogenesis because its activity is reduced in these situations (3,4), and it is known that angiotensin II (Ang II) is involved in regulating renal growth and differentiation (11). The role of Ang II in renal development has been confirmed in studies demonstrating an elevation of all RAS components during the nephrogenic period and showing that the administration of either a converting enzyme inhibitor or an Ang II AT1 receptor antagonist during this period leads to a significant reduction in nephron number and an alteration of the normal kidney structure (7,8).
publishDate 2008
dc.date.none.fl_str_mv 2008-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/148574
url http://sedici.unlp.edu.ar/handle/10915/148574
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/issue/importance-of-nephron-number-in-the-regulation-of-arterial-pressure-and-renal-function-during-ageing/
info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
17-24
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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