Residue depletion of ivermectin in broiler poultry

Autores
Mestorino, Olga Nora; Buldain, Daniel Cornelio; Buchamer, Andrea Verónica; Gortari Castillo, Lihuel; Daniele, Martín Rafael; Marchetti, María Laura
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg–1 feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C18 cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
Facultad de Ciencias Veterinarias
Materia
Veterinaria
endectocide
ivermectin
chicken
residues
withdrawal time
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/106189
Acceder
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network_acronym_str SEDICI
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network_name_str SEDICI (UNLP)
spelling Residue depletion of ivermectin in broiler poultryMestorino, Olga NoraBuldain, Daniel CornelioBuchamer, Andrea VerónicaGortari Castillo, LihuelDaniele, Martín RafaelMarchetti, María LauraVeterinariaendectocideivermectinchickenresidueswithdrawal timeHelminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg<sup>–1</sup> feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C<sub>18</sub> cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.Facultad de Ciencias Veterinarias2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf624-631http://sedici.unlp.edu.ar/handle/10915/106189enginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1278307info:eu-repo/semantics/altIdentifier/issn/1944-0057info:eu-repo/semantics/altIdentifier/doi/10.1080/19440049.2016.1278307info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:01Zoai:sedici.unlp.edu.ar:10915/106189Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:01.798SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Residue depletion of ivermectin in broiler poultry
title Residue depletion of ivermectin in broiler poultry
spellingShingle Residue depletion of ivermectin in broiler poultry
Mestorino, Olga Nora
Veterinaria
endectocide
ivermectin
chicken
residues
withdrawal time
title_short Residue depletion of ivermectin in broiler poultry
title_full Residue depletion of ivermectin in broiler poultry
title_fullStr Residue depletion of ivermectin in broiler poultry
title_full_unstemmed Residue depletion of ivermectin in broiler poultry
title_sort Residue depletion of ivermectin in broiler poultry
dc.creator.none.fl_str_mv Mestorino, Olga Nora
Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Gortari Castillo, Lihuel
Daniele, Martín Rafael
Marchetti, María Laura
author Mestorino, Olga Nora
author_facet Mestorino, Olga Nora
Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Gortari Castillo, Lihuel
Daniele, Martín Rafael
Marchetti, María Laura
author_role author
author2 Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Gortari Castillo, Lihuel
Daniele, Martín Rafael
Marchetti, María Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Veterinaria
endectocide
ivermectin
chicken
residues
withdrawal time
topic Veterinaria
endectocide
ivermectin
chicken
residues
withdrawal time
dc.description.none.fl_txt_mv Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg<sup>–1</sup> feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C<sub>18</sub> cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
Facultad de Ciencias Veterinarias
description Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg<sup>–1</sup> feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C<sub>18</sub> cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/106189
url http://sedici.unlp.edu.ar/handle/10915/106189
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1278307
info:eu-repo/semantics/altIdentifier/issn/1944-0057
info:eu-repo/semantics/altIdentifier/doi/10.1080/19440049.2016.1278307
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
624-631
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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