Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening

Autores
Mestorino, Olga Nora; Zeinsteger, Pedro Adolfo; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Aliverti, Florencia; Marchetti, Maria Laura
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. The objective of this study was to evaluate the withdrawal time (WT) of DOX formulation at 25 % in edible tissues, after its oral (PO) use in broilers. Forty healthy chicks (30–35 days of age) were used. DOX was administered with drinking water for 5 days at 10 mg kg–1 (N = 36); four untreated animals were reserved (control). Six animals per group were euthanized by cervical dislocation after desensitization by passage of an electric current through the head, after 24 hours until 9 d post treatment and control animals also. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. It was estimated 6.58, 8.18, 8.69 and 6.96 d of WT for muscle, liver, kidney and skin/fat, respectively. After DOX administration at a rate of 10 mg kg–1 for 5 days in drinking water, a WT of 9 d is suggested in poultry destined for human consumption.
Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zeinsteger, Pedro Adolfo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aliverti, Florencia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marchetti, Maria Laura. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
antimicrobials
doxycycline
poultry
tissues
residues
withdrawal time
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86329
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86329
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tissue depletion of doxycycline after its oral administration in food producing chicken for fatteningMestorino, Olga NoraZeinsteger, Pedro AdolfoBuchamer, Andrea VeronicaBuldain, Daniel CornelioAliverti, FlorenciaMarchetti, Maria Lauraantimicrobialsdoxycyclinepoultrytissuesresidueswithdrawal timehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. The objective of this study was to evaluate the withdrawal time (WT) of DOX formulation at 25 % in edible tissues, after its oral (PO) use in broilers. Forty healthy chicks (30–35 days of age) were used. DOX was administered with drinking water for 5 days at 10 mg kg–1 (N = 36); four untreated animals were reserved (control). Six animals per group were euthanized by cervical dislocation after desensitization by passage of an electric current through the head, after 24 hours until 9 d post treatment and control animals also. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. It was estimated 6.58, 8.18, 8.69 and 6.96 d of WT for muscle, liver, kidney and skin/fat, respectively. After DOX administration at a rate of 10 mg kg–1 for 5 days in drinking water, a WT of 9 d is suggested in poultry destined for human consumption.Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zeinsteger, Pedro Adolfo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aliverti, Florencia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marchetti, Maria Laura. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMed Crave2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86329Mestorino, Olga Nora; Zeinsteger, Pedro Adolfo; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Aliverti, Florencia; et al.; Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening; Med Crave; International Journal of Avian & Wildlife Biology (IJAWB); 3; 6-2018; 252-2572574-9862CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15406/ijawb.2018.03.00095info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/IJAWB/IJAWB-03-00095.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:05Zoai:ri.conicet.gov.ar:11336/86329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:05.471CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
title Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
spellingShingle Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
Mestorino, Olga Nora
antimicrobials
doxycycline
poultry
tissues
residues
withdrawal time
title_short Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
title_full Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
title_fullStr Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
title_full_unstemmed Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
title_sort Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
dc.creator.none.fl_str_mv Mestorino, Olga Nora
Zeinsteger, Pedro Adolfo
Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Aliverti, Florencia
Marchetti, Maria Laura
author Mestorino, Olga Nora
author_facet Mestorino, Olga Nora
Zeinsteger, Pedro Adolfo
Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Aliverti, Florencia
Marchetti, Maria Laura
author_role author
author2 Zeinsteger, Pedro Adolfo
Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Aliverti, Florencia
Marchetti, Maria Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv antimicrobials
doxycycline
poultry
tissues
residues
withdrawal time
topic antimicrobials
doxycycline
poultry
tissues
residues
withdrawal time
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. The objective of this study was to evaluate the withdrawal time (WT) of DOX formulation at 25 % in edible tissues, after its oral (PO) use in broilers. Forty healthy chicks (30–35 days of age) were used. DOX was administered with drinking water for 5 days at 10 mg kg–1 (N = 36); four untreated animals were reserved (control). Six animals per group were euthanized by cervical dislocation after desensitization by passage of an electric current through the head, after 24 hours until 9 d post treatment and control animals also. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. It was estimated 6.58, 8.18, 8.69 and 6.96 d of WT for muscle, liver, kidney and skin/fat, respectively. After DOX administration at a rate of 10 mg kg–1 for 5 days in drinking water, a WT of 9 d is suggested in poultry destined for human consumption.
Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zeinsteger, Pedro Adolfo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aliverti, Florencia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marchetti, Maria Laura. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. The objective of this study was to evaluate the withdrawal time (WT) of DOX formulation at 25 % in edible tissues, after its oral (PO) use in broilers. Forty healthy chicks (30–35 days of age) were used. DOX was administered with drinking water for 5 days at 10 mg kg–1 (N = 36); four untreated animals were reserved (control). Six animals per group were euthanized by cervical dislocation after desensitization by passage of an electric current through the head, after 24 hours until 9 d post treatment and control animals also. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. It was estimated 6.58, 8.18, 8.69 and 6.96 d of WT for muscle, liver, kidney and skin/fat, respectively. After DOX administration at a rate of 10 mg kg–1 for 5 days in drinking water, a WT of 9 d is suggested in poultry destined for human consumption.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86329
Mestorino, Olga Nora; Zeinsteger, Pedro Adolfo; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Aliverti, Florencia; et al.; Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening; Med Crave; International Journal of Avian & Wildlife Biology (IJAWB); 3; 6-2018; 252-257
2574-9862
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86329
identifier_str_mv Mestorino, Olga Nora; Zeinsteger, Pedro Adolfo; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Aliverti, Florencia; et al.; Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening; Med Crave; International Journal of Avian & Wildlife Biology (IJAWB); 3; 6-2018; 252-257
2574-9862
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15406/ijawb.2018.03.00095
info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/IJAWB/IJAWB-03-00095.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Med Crave
publisher.none.fl_str_mv Med Crave
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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