Residue depletion of ivermectin in broiler poultry

Autores
Mestorino, Olga Nora; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Gortari Castillo, Lihuel; Daniele, Martin Rafael; Marchetti, Maria Laura
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg?1 feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C18 cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gortari Castillo, Lihuel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Daniele, Martin Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
Chicken
Endectocide
Ivermectin
Residues
Withdrawal Time
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78157
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Residue depletion of ivermectin in broiler poultryMestorino, Olga NoraBuldain, Daniel CornelioBuchamer, Andrea VeronicaGortari Castillo, LihuelDaniele, Martin RafaelMarchetti, Maria LauraChickenEndectocideIvermectinResiduesWithdrawal Timehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg?1 feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C18 cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Gortari Castillo, Lihuel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Daniele, Martin Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaTaylor & Francis2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78157Mestorino, Olga Nora; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Gortari Castillo, Lihuel; Daniele, Martin Rafael; et al.; Residue depletion of ivermectin in broiler poultry; Taylor & Francis; Food Additives and Contaminants; 34; 4; 4-2017; 624-6311944-00491944-0057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1278307info:eu-repo/semantics/altIdentifier/doi/10.1080/19440049.2016.1278307info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:19Zoai:ri.conicet.gov.ar:11336/78157instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:19.758CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Residue depletion of ivermectin in broiler poultry
title Residue depletion of ivermectin in broiler poultry
spellingShingle Residue depletion of ivermectin in broiler poultry
Mestorino, Olga Nora
Chicken
Endectocide
Ivermectin
Residues
Withdrawal Time
title_short Residue depletion of ivermectin in broiler poultry
title_full Residue depletion of ivermectin in broiler poultry
title_fullStr Residue depletion of ivermectin in broiler poultry
title_full_unstemmed Residue depletion of ivermectin in broiler poultry
title_sort Residue depletion of ivermectin in broiler poultry
dc.creator.none.fl_str_mv Mestorino, Olga Nora
Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Gortari Castillo, Lihuel
Daniele, Martin Rafael
Marchetti, Maria Laura
author Mestorino, Olga Nora
author_facet Mestorino, Olga Nora
Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Gortari Castillo, Lihuel
Daniele, Martin Rafael
Marchetti, Maria Laura
author_role author
author2 Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Gortari Castillo, Lihuel
Daniele, Martin Rafael
Marchetti, Maria Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Chicken
Endectocide
Ivermectin
Residues
Withdrawal Time
topic Chicken
Endectocide
Ivermectin
Residues
Withdrawal Time
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg?1 feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C18 cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
Fil: Mestorino, Olga Nora. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gortari Castillo, Lihuel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Daniele, Martin Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg?1 feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C18 cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78157
Mestorino, Olga Nora; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Gortari Castillo, Lihuel; Daniele, Martin Rafael; et al.; Residue depletion of ivermectin in broiler poultry; Taylor & Francis; Food Additives and Contaminants; 34; 4; 4-2017; 624-631
1944-0049
1944-0057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78157
identifier_str_mv Mestorino, Olga Nora; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Gortari Castillo, Lihuel; Daniele, Martin Rafael; et al.; Residue depletion of ivermectin in broiler poultry; Taylor & Francis; Food Additives and Contaminants; 34; 4; 4-2017; 624-631
1944-0049
1944-0057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/19440049.2016.1278307
info:eu-repo/semantics/altIdentifier/doi/10.1080/19440049.2016.1278307
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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