Tissue depletion profile of ivermectin in rabbits

Autores
Marchetti, Maria Laura; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Zeinsteger, Pedro Adolfo; Mestorino, Olga Nora
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment.
Fil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Zeinsteger, Pedro Adolfo. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Materia
IVERMECTIN
TISSUES
RESIDUES
WITHDRAWAL TIME
RABBIT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145771
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145771
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tissue depletion profile of ivermectin in rabbitsMarchetti, Maria LauraBuldain, Daniel CornelioBuchamer, Andrea VeronicaZeinsteger, Pedro AdolfoMestorino, Olga NoraIVERMECTINTISSUESRESIDUESWITHDRAWAL TIMERABBIThttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment.Fil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; ArgentinaFil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; ArgentinaFil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; ArgentinaFil: Zeinsteger, Pedro Adolfo. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; ArgentinaFil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; ArgentinaECronicon2020-07-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145771Marchetti, Maria Laura; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Zeinsteger, Pedro Adolfo; Mestorino, Olga Nora; Tissue depletion profile of ivermectin in rabbits; ECronicon; EC Veterinary Science; 5; 8; 11-7-2020; 62-712306-7381CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ecronicon.com/ecve/ECVE-05-00270.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:51Zoai:ri.conicet.gov.ar:11336/145771instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:51.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tissue depletion profile of ivermectin in rabbits
title Tissue depletion profile of ivermectin in rabbits
spellingShingle Tissue depletion profile of ivermectin in rabbits
Marchetti, Maria Laura
IVERMECTIN
TISSUES
RESIDUES
WITHDRAWAL TIME
RABBIT
title_short Tissue depletion profile of ivermectin in rabbits
title_full Tissue depletion profile of ivermectin in rabbits
title_fullStr Tissue depletion profile of ivermectin in rabbits
title_full_unstemmed Tissue depletion profile of ivermectin in rabbits
title_sort Tissue depletion profile of ivermectin in rabbits
dc.creator.none.fl_str_mv Marchetti, Maria Laura
Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
author Marchetti, Maria Laura
author_facet Marchetti, Maria Laura
Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
author_role author
author2 Buldain, Daniel Cornelio
Buchamer, Andrea Veronica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
author2_role author
author
author
author
dc.subject.none.fl_str_mv IVERMECTIN
TISSUES
RESIDUES
WITHDRAWAL TIME
RABBIT
topic IVERMECTIN
TISSUES
RESIDUES
WITHDRAWAL TIME
RABBIT
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment.
Fil: Marchetti, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Buldain, Daniel Cornelio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Zeinsteger, Pedro Adolfo. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
Fil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacologicos y Toxicologicos.; Argentina
description Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145771
Marchetti, Maria Laura; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Zeinsteger, Pedro Adolfo; Mestorino, Olga Nora; Tissue depletion profile of ivermectin in rabbits; ECronicon; EC Veterinary Science; 5; 8; 11-7-2020; 62-71
2306-7381
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145771
identifier_str_mv Marchetti, Maria Laura; Buldain, Daniel Cornelio; Buchamer, Andrea Veronica; Zeinsteger, Pedro Adolfo; Mestorino, Olga Nora; Tissue depletion profile of ivermectin in rabbits; ECronicon; EC Veterinary Science; 5; 8; 11-7-2020; 62-71
2306-7381
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ecronicon.com/ecve/ECVE-05-00270.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ECronicon
publisher.none.fl_str_mv ECronicon
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268998785302528
score 13.13397

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