Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
- Autores
- Urquiza, Nora M.; Manca, Silvia G.; Moyano, María Alejandra; Dellmans, Raquel Arrieta; Lezama, Luis; Rojo, Teófilo; Naso, Luciana Gissella; Williams, Patricia Ana María; Ferrer, Evelina Gloria
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2·H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.
Centro de Química Inorgánica - Materia
-
Química
Methimazole
Copper
Biometals
Grave’s disease
EPR
FTIR
UV-visible
ALP inhibition - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/133155
Ver los metadatos del registro completo
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Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitorUrquiza, Nora M.Manca, Silvia G.Moyano, María AlejandraDellmans, Raquel ArrietaLezama, LuisRojo, TeófiloNaso, Luciana GissellaWilliams, Patricia Ana MaríaFerrer, Evelina GloriaQuímicaMethimazoleCopperBiometalsGrave’s diseaseEPRFTIRUV-visibleALP inhibitionMethimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.Centro de Química Inorgánica2009-12-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf255-264http://sedici.unlp.edu.ar/handle/10915/133155enginfo:eu-repo/semantics/altIdentifier/issn/1572-8773info:eu-repo/semantics/altIdentifier/issn/0966-0844info:eu-repo/semantics/altIdentifier/doi/10.1007/s10534-009-9283-7info:eu-repo/semantics/altIdentifier/pmid/20012553info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:43Zoai:sedici.unlp.edu.ar:10915/133155Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:43.469SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| title |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| spellingShingle |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor Urquiza, Nora M. Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition |
| title_short |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| title_full |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| title_fullStr |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| title_full_unstemmed |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| title_sort |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
| dc.creator.none.fl_str_mv |
Urquiza, Nora M. Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria |
| author |
Urquiza, Nora M. |
| author_facet |
Urquiza, Nora M. Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria |
| author_role |
author |
| author2 |
Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition |
| topic |
Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition |
| dc.description.none.fl_txt_mv |
Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. Centro de Química Inorgánica |
| description |
Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-12-11 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/133155 |
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http://sedici.unlp.edu.ar/handle/10915/133155 |
| dc.language.none.fl_str_mv |
eng |
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eng |
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openAccess |
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