Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex

Autores
Urquiza, Nora María; Islas, María Soledad; Dittler, Maria Laura; Moyano, Maria A.; Manca, Silvia Graciela; Lezama, Luis; Rojo, Teófilo; Martínez Medina, Juan José; Diez, Maximiliano; López Tévez, Libertad Leonor; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves’ disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary [Cu(MeimzH)2 (phen)(H2O)2]Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV–Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary [Cu(MeimzH)2(H2O)2](NO3)2H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, [Cu(phen)2Cl]Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: CuMet > Cu-Phen > Cu-Met-Phen.
Fil: Urquiza, Nora María. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Dittler, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Moyano, Maria A.. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Manca, Silvia Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Lezama, Luis. Universidad del País Vasco; España
Fil: Rojo, Teófilo. Universidad del País Vasco; España
Fil: Martínez Medina, Juan José. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral; Argentina
Fil: López Tévez, Libertad Leonor. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Materia
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24962
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24962
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complexUrquiza, Nora MaríaIslas, María SoledadDittler, Maria LauraMoyano, Maria A.Manca, Silvia GracielaLezama, LuisRojo, TeófiloMartínez Medina, Juan JoséDiez, MaximilianoLópez Tévez, Libertad LeonorWilliams, Patricia Ana MaríaFerrer, Evelina GloriaMethimazolePhenanthrolineCopper(Ii)Sod ActivityAlp InhibitionAntibacterial Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves’ disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary [Cu(MeimzH)2 (phen)(H2O)2]Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV–Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary [Cu(MeimzH)2(H2O)2](NO3)2H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, [Cu(phen)2Cl]Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: CuMet > Cu-Phen > Cu-Met-Phen.Fil: Urquiza, Nora María. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; ArgentinaFil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Dittler, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Moyano, Maria A.. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; ArgentinaFil: Manca, Silvia Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; ArgentinaFil: Lezama, Luis. Universidad del País Vasco; EspañaFil: Rojo, Teófilo. Universidad del País Vasco; EspañaFil: Martínez Medina, Juan José. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diez, Maximiliano. Universidad Nacional del Chaco Austral; ArgentinaFil: López Tévez, Libertad Leonor. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaElsevier Science Sa2013-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24962Urquiza, Nora María; Islas, María Soledad; Dittler, Maria Laura; Moyano, Maria A.; Manca, Silvia Graciela; et al.; Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex; Elsevier Science Sa; Inorganica Chimica Acta; 405; 24-8-2013; 243-2510020-1693CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0020169313002958info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:50:54Zoai:ri.conicet.gov.ar:11336/24962instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:50:54.894CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
title Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
spellingShingle Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
Urquiza, Nora María
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
title_short Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
title_full Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
title_fullStr Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
title_full_unstemmed Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
title_sort Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex
dc.creator.none.fl_str_mv Urquiza, Nora María
Islas, María Soledad
Dittler, Maria Laura
Moyano, Maria A.
Manca, Silvia Graciela
Lezama, Luis
Rojo, Teófilo
Martínez Medina, Juan José
Diez, Maximiliano
López Tévez, Libertad Leonor
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Urquiza, Nora María
author_facet Urquiza, Nora María
Islas, María Soledad
Dittler, Maria Laura
Moyano, Maria A.
Manca, Silvia Graciela
Lezama, Luis
Rojo, Teófilo
Martínez Medina, Juan José
Diez, Maximiliano
López Tévez, Libertad Leonor
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Islas, María Soledad
Dittler, Maria Laura
Moyano, Maria A.
Manca, Silvia Graciela
Lezama, Luis
Rojo, Teófilo
Martínez Medina, Juan José
Diez, Maximiliano
López Tévez, Libertad Leonor
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
topic Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves’ disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary [Cu(MeimzH)2 (phen)(H2O)2]Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV–Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary [Cu(MeimzH)2(H2O)2](NO3)2H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, [Cu(phen)2Cl]Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: CuMet > Cu-Phen > Cu-Met-Phen.
Fil: Urquiza, Nora María. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Dittler, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Moyano, Maria A.. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Manca, Silvia Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina
Fil: Lezama, Luis. Universidad del País Vasco; España
Fil: Rojo, Teófilo. Universidad del País Vasco; España
Fil: Martínez Medina, Juan José. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral; Argentina
Fil: López Tévez, Libertad Leonor. Universidad Nacional del Chaco Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
description Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves’ disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary [Cu(MeimzH)2 (phen)(H2O)2]Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV–Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary [Cu(MeimzH)2(H2O)2](NO3)2H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, [Cu(phen)2Cl]Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: CuMet > Cu-Phen > Cu-Met-Phen.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24962
Urquiza, Nora María; Islas, María Soledad; Dittler, Maria Laura; Moyano, Maria A.; Manca, Silvia Graciela; et al.; Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex; Elsevier Science Sa; Inorganica Chimica Acta; 405; 24-8-2013; 243-251
0020-1693
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24962
identifier_str_mv Urquiza, Nora María; Islas, María Soledad; Dittler, Maria Laura; Moyano, Maria A.; Manca, Silvia Graciela; et al.; Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex; Elsevier Science Sa; Inorganica Chimica Acta; 405; 24-8-2013; 243-251
0020-1693
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0020169313002958
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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