Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels

Autores
Guerra, Liliana Noemi; Rios, Maria del Carmen; Miler, Eliana Andrea; Moiguer, Silvia; Karner, Mirta; Burdman, Jose Adolfo
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism.
Fil: Guerra, Liliana Noemi. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Hospital Israelita; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Miler, Eliana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Moiguer, Silvia. Hospital Israelita; Argentina
Fil: Karner, Mirta. Hospital Israelita; Argentina
Fil: Burdman, Jose Adolfo. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Israelita; Argentina
Materia
HYPERTHYROIDISM
MALONDIALDEHYDE
METHIMAZOLE (MMI)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98819
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98819
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levelsGuerra, Liliana NoemiRios, Maria del CarmenMiler, Eliana AndreaMoiguer, SilviaKarner, MirtaBurdman, Jose AdolfoHYPERTHYROIDISMMALONDIALDEHYDEMETHIMAZOLE (MMI)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism.Fil: Guerra, Liliana Noemi. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Hospital Israelita; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Miler, Eliana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Moiguer, Silvia. Hospital Israelita; ArgentinaFil: Karner, Mirta. Hospital Israelita; ArgentinaFil: Burdman, Jose Adolfo. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Israelita; ArgentinaElsevier Science2005-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98819Guerra, Liliana Noemi; Rios, Maria del Carmen; Miler, Eliana Andrea; Moiguer, Silvia; Karner, Mirta; et al.; Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels; Elsevier Science; Clinica Chimica Acta; 352; 1-2; 2-2005; 115-1200009-8981CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009898104004681info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cccn.2004.08.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:23Zoai:ri.conicet.gov.ar:11336/98819instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:23.939CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
title Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
spellingShingle Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
Guerra, Liliana Noemi
HYPERTHYROIDISM
MALONDIALDEHYDE
METHIMAZOLE (MMI)
title_short Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
title_full Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
title_fullStr Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
title_full_unstemmed Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
title_sort Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels
dc.creator.none.fl_str_mv Guerra, Liliana Noemi
Rios, Maria del Carmen
Miler, Eliana Andrea
Moiguer, Silvia
Karner, Mirta
Burdman, Jose Adolfo
author Guerra, Liliana Noemi
author_facet Guerra, Liliana Noemi
Rios, Maria del Carmen
Miler, Eliana Andrea
Moiguer, Silvia
Karner, Mirta
Burdman, Jose Adolfo
author_role author
author2 Rios, Maria del Carmen
Miler, Eliana Andrea
Moiguer, Silvia
Karner, Mirta
Burdman, Jose Adolfo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HYPERTHYROIDISM
MALONDIALDEHYDE
METHIMAZOLE (MMI)
topic HYPERTHYROIDISM
MALONDIALDEHYDE
METHIMAZOLE (MMI)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism.
Fil: Guerra, Liliana Noemi. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Hospital Israelita; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Miler, Eliana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Moiguer, Silvia. Hospital Israelita; Argentina
Fil: Karner, Mirta. Hospital Israelita; Argentina
Fil: Burdman, Jose Adolfo. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Israelita; Argentina
description We have postulated that metabolic oxidation could be the source of signs and symptoms of hyperthyroidism. The present study was designed to evaluate urinary malondialdehyde levels in Graves' disease and compare this oxidative stress biomarker with the clinical evolution of patients suffering this illness. We evaluated the concentration of urinary and serum malondialdehyde (MDA) in 36 patients with Graves' disease. Patients were treated with the antithyroid drug methimazole (MMI; Group A) or antioxidant mixture (200 mg vitamin E, 3 mg β-carotene, 250 mg vitamin C, 1 mg Cu, 7.5 mg Zn, 1.5 mg Mn, and 15 μg Se; Group B). MDA concentrations were higher in hyperthyroid patients compared to euthyroid controls, and a positive correlation was observed between serum and urinary MDA levels. Group A decreased urinary MDA to control values. There was a positive correlation between the clinical score and the heart rate of patients with urinary MDA before and during the treatment with MMI (Group A). Similar results were observed after treatment with the antioxidant mixture. Urinary MDA might be a good parameter in the follow-up of patients during MMI treatment. We proposed that oxidative stress correlates with signs and symptoms of hyperthyroidism.
publishDate 2005
dc.date.none.fl_str_mv 2005-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98819
Guerra, Liliana Noemi; Rios, Maria del Carmen; Miler, Eliana Andrea; Moiguer, Silvia; Karner, Mirta; et al.; Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels; Elsevier Science; Clinica Chimica Acta; 352; 1-2; 2-2005; 115-120
0009-8981
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98819
identifier_str_mv Guerra, Liliana Noemi; Rios, Maria del Carmen; Miler, Eliana Andrea; Moiguer, Silvia; Karner, Mirta; et al.; Antioxidants and methimazole in the treatment of Graves' disease: Effect on urinary malondialdehyde levels; Elsevier Science; Clinica Chimica Acta; 352; 1-2; 2-2005; 115-120
0009-8981
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009898104004681
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cccn.2004.08.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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