Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
- Autores
- Urquiza, Nora M.; Islas, Soledad M.; Dittler, María Laura; Moyano, María A.; Manca, Silvia G.; Ledezma, Luis; Rojo, Teófilo; Martínez Medina, Juan J.; Diez, Maximiliano; López Tévez, Leonor; Williams, Patricia A.M; Ferrer, Evelina G.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).
Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas.
Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP). - Fuente
- Inorganica Chimica, 405, 243-251. (2013)
ISSN 0020-1693 - Materia
-
Biología
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
- OAI Identificador
- oai:memoria.fahce.unlp.edu.ar:snrd:Jpr18710
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Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complexUrquiza, Nora M.Islas, Soledad M.Dittler, María LauraMoyano, María A.Manca, Silvia G.Ledezma, LuisRojo, TeófiloMartínez Medina, Juan J.Diez, MaximilianoLópez Tévez, LeonorWilliams, Patricia A.MFerrer, Evelina G.BiologíaMethimazolePhenanthrolineCopper(Ii)Sod ActivityAlp InhibitionAntibacterial ActivityMethimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas.Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdfInorganica Chimica, 405, 243-251. (2013)ISSN 0020-1693reponame:Memoria Académica (UNLP-FAHCE)instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educacióninstacron:UNLPenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-10-16T09:27:23Zoai:memoria.fahce.unlp.edu.ar:snrd:Jpr18710Institucionalhttps://www.memoria.fahce.unlp.edu.ar/Universidad públicahttps://www.fahce.unlp.edu.ar/https://www.memoria.fahce.unlp.edu.ar/oaiserver.cgimemoria@fahce.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13412025-10-16 09:27:23.954Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educaciónfalse |
dc.title.none.fl_str_mv |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
title |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
spellingShingle |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex Urquiza, Nora M. Biología Methimazole Phenanthroline Copper(Ii) Sod Activity Alp Inhibition Antibacterial Activity |
title_short |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
title_full |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
title_fullStr |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
title_full_unstemmed |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
title_sort |
Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex |
dc.creator.none.fl_str_mv |
Urquiza, Nora M. Islas, Soledad M. Dittler, María Laura Moyano, María A. Manca, Silvia G. Ledezma, Luis Rojo, Teófilo Martínez Medina, Juan J. Diez, Maximiliano López Tévez, Leonor Williams, Patricia A.M Ferrer, Evelina G. |
author |
Urquiza, Nora M. |
author_facet |
Urquiza, Nora M. Islas, Soledad M. Dittler, María Laura Moyano, María A. Manca, Silvia G. Ledezma, Luis Rojo, Teófilo Martínez Medina, Juan J. Diez, Maximiliano López Tévez, Leonor Williams, Patricia A.M Ferrer, Evelina G. |
author_role |
author |
author2 |
Islas, Soledad M. Dittler, María Laura Moyano, María A. Manca, Silvia G. Ledezma, Luis Rojo, Teófilo Martínez Medina, Juan J. Diez, Maximiliano López Tévez, Leonor Williams, Patricia A.M Ferrer, Evelina G. |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Biología Methimazole Phenanthroline Copper(Ii) Sod Activity Alp Inhibition Antibacterial Activity |
topic |
Biología Methimazole Phenanthroline Copper(Ii) Sod Activity Alp Inhibition Antibacterial Activity |
dc.description.none.fl_txt_mv |
Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen. Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina. Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica. Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP). Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica. Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica. Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica. Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica. Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química. Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química. Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química. Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas. Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP). |
description |
Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdf |
url |
https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdf |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Inorganica Chimica, 405, 243-251. (2013) ISSN 0020-1693 reponame:Memoria Académica (UNLP-FAHCE) instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación instacron:UNLP |
reponame_str |
Memoria Académica (UNLP-FAHCE) |
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Memoria Académica (UNLP-FAHCE) |
instname_str |
Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación |
repository.mail.fl_str_mv |
memoria@fahce.unlp.edu.ar |
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12.712165 |