Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex

Autores
Urquiza, Nora M.; Islas, Soledad M.; Dittler, María Laura; Moyano, María A.; Manca, Silvia G.; Ledezma, Luis; Rojo, Teófilo; Martínez Medina, Juan J.; Diez, Maximiliano; López Tévez, Leonor; Williams, Patricia A.M; Ferrer, Evelina G.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).
Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas.
Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).
Fuente
Inorganica Chimica, 405, 243-251. (2013)
ISSN 0020-1693
Materia
Biología
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Memoria Académica (UNLP-FAHCE)
Institución
Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
OAI Identificador
oai:memoria.fahce.unlp.edu.ar:snrd:Jpr18710

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oai_identifier_str oai:memoria.fahce.unlp.edu.ar:snrd:Jpr18710
network_acronym_str MemAca
repository_id_str 1341
network_name_str Memoria Académica (UNLP-FAHCE)
spelling Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complexUrquiza, Nora M.Islas, Soledad M.Dittler, María LauraMoyano, María A.Manca, Silvia G.Ledezma, LuisRojo, TeófiloMartínez Medina, Juan J.Diez, MaximilianoLópez Tévez, LeonorWilliams, Patricia A.MFerrer, Evelina G.BiologíaMethimazolePhenanthrolineCopper(Ii)Sod ActivityAlp InhibitionAntibacterial ActivityMethimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química.Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas.Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdfInorganica Chimica, 405, 243-251. (2013)ISSN 0020-1693reponame:Memoria Académica (UNLP-FAHCE)instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educacióninstacron:UNLPenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-10-16T09:27:23Zoai:memoria.fahce.unlp.edu.ar:snrd:Jpr18710Institucionalhttps://www.memoria.fahce.unlp.edu.ar/Universidad públicahttps://www.fahce.unlp.edu.ar/https://www.memoria.fahce.unlp.edu.ar/oaiserver.cgimemoria@fahce.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13412025-10-16 09:27:23.954Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educaciónfalse
dc.title.none.fl_str_mv Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
title Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
spellingShingle Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
Urquiza, Nora M.
Biología
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
title_short Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
title_full Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
title_fullStr Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
title_full_unstemmed Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
title_sort Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole-phenanthroline-copper(II) complex
dc.creator.none.fl_str_mv Urquiza, Nora M.
Islas, Soledad M.
Dittler, María Laura
Moyano, María A.
Manca, Silvia G.
Ledezma, Luis
Rojo, Teófilo
Martínez Medina, Juan J.
Diez, Maximiliano
López Tévez, Leonor
Williams, Patricia A.M
Ferrer, Evelina G.
author Urquiza, Nora M.
author_facet Urquiza, Nora M.
Islas, Soledad M.
Dittler, María Laura
Moyano, María A.
Manca, Silvia G.
Ledezma, Luis
Rojo, Teófilo
Martínez Medina, Juan J.
Diez, Maximiliano
López Tévez, Leonor
Williams, Patricia A.M
Ferrer, Evelina G.
author_role author
author2 Islas, Soledad M.
Dittler, María Laura
Moyano, María A.
Manca, Silvia G.
Ledezma, Luis
Rojo, Teófilo
Martínez Medina, Juan J.
Diez, Maximiliano
López Tévez, Leonor
Williams, Patricia A.M
Ferrer, Evelina G.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
topic Biología
Methimazole
Phenanthroline
Copper(Ii)
Sod Activity
Alp Inhibition
Antibacterial Activity
dc.description.none.fl_txt_mv Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Urquiza, Nora M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Islas, Soledad M.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).
Fil: Moyano, María A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Manca, Silvia G.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analítica.
Fil: Ledezma, Luis. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Rojo, Teófilo. Universidad del País Vasco.Facultad de Ciencia y Tecnología. Departamento de Química Inorgánica.
Fil: Martínez Medina, Juan J.. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Diez, Maximiliano. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: López Tévez, Leonor. Universidad Nacional del Chaco Austral. Departamento de Química.
Fil: Williams, Patricia A.M. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias Exactas.
Fil: Ferrer, Evelina G.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP).
description Methimazole (MeimzH), a sulfur containing compound, is an antithyroid drug commonly used to treat Graves' disease acting as an inhibitor of the enzyme thyroid peroxidase. A new ternary (Cu(MeimzH)2 (phen)(H2O)2)Cl2 (Cu-Met-phen) complex of this drug containing also phenanthroline as a second ligand (phen) was synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis, UV?Vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is previously reported, the binary (Cu(MeimzH)2(H2O)2)(NO3)2 H2O (Cu-Met) complex can act as an inhibitor of alkaline phosphatase (ALP). In this work, the inhibitory effect of methimazole, phenanthroline, (Cu(phen)2Cl)Cl (Cu-phen) and the new ternary complex has also been investigated and compared with Cu-Met together with in vitro tests of susceptibility against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis bacteria. To our knowledge, the antibacterial activity of methimazole is determined for the first time. For the ternary complex, the results show that the coordination of the drug increased its antibacterial effect especially against E. faecalis demonstrating a strong effect against S. aureus and S. epidermidis. The assays also indicate that in same strains the new complex show better activity than their ligands. The ability for the inhibition of alkaline phosphatase (ALP) was lower than that of the binary complex (Cu-Met) probably due to the absence of labile ligands around the metal center. Moreover, the antioxidant activity of the complexes decreases as follows: Cu-Met > Cu-Phen > Cu-Met-Phen.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdf
url https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18710/pr.18710.pdf
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2013.05.022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Inorganica Chimica, 405, 243-251. (2013)
ISSN 0020-1693
reponame:Memoria Académica (UNLP-FAHCE)
instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
instacron:UNLP
reponame_str Memoria Académica (UNLP-FAHCE)
collection Memoria Académica (UNLP-FAHCE)
instname_str Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
repository.mail.fl_str_mv memoria@fahce.unlp.edu.ar
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