Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish

Autores
Prieto, María Jimena; Carreno Gutiérrez, Héctor; Arévalo Arévalo, Rosario; Chiaramoni, Nadia Silvia; Alonso, Silvia del Valle
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
Instituto Multidisciplinario de Biología Celular
Materia
Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/95713
Acceder
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spelling Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of ZebrafishPrieto, María JimenaCarreno Gutiérrez, HéctorArévalo Arévalo, RosarioChiaramoni, Nadia SilviaAlonso, Silvia del ValleBiologíaZebrafishRisperidoneFluoxetineSerotonineBehavioralBrain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.Instituto Multidisciplinario de Biología Celular2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf129-138http://sedici.unlp.edu.ar/handle/10915/95713enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/70794info:eu-repo/semantics/altIdentifier/url/https://file.scirp.org/Html/4-1790020_26234.htminfo:eu-repo/semantics/altIdentifier/issn/2164-3121info:eu-repo/semantics/altIdentifier/doi/10.4236/ojmc.2012.24016info:eu-repo/semantics/altIdentifier/hdl/11336/70794info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:03:04Zoai:sedici.unlp.edu.ar:10915/95713Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:03:04.956SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
spellingShingle Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
Prieto, María Jimena
Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
title_short Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_full Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_fullStr Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_full_unstemmed Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_sort Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
dc.creator.none.fl_str_mv Prieto, María Jimena
Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author Prieto, María Jimena
author_facet Prieto, María Jimena
Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author_role author
author2 Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
topic Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
dc.description.none.fl_txt_mv Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
Instituto Multidisciplinario de Biología Celular
description Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/95713
url http://sedici.unlp.edu.ar/handle/10915/95713
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/70794
info:eu-repo/semantics/altIdentifier/url/https://file.scirp.org/Html/4-1790020_26234.htm
info:eu-repo/semantics/altIdentifier/issn/2164-3121
info:eu-repo/semantics/altIdentifier/doi/10.4236/ojmc.2012.24016
info:eu-repo/semantics/altIdentifier/hdl/11336/70794
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
129-138
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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