Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells

Autores
Molinuevo, María Silvina; Cortizo, Ana María; Etcheverry, Susana Beatriz
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this effect usually signifies serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123725
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/123725
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cellsMolinuevo, María SilvinaCortizo, Ana MaríaEtcheverry, Susana BeatrizCiencias ExactasBioquímicaVanadiumCancerMetastasisOsteosarcomaVanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this effect usually signifies serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.Facultad de Ciencias Exactas2008-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf767-773http://sedici.unlp.edu.ar/handle/10915/123725enginfo:eu-repo/semantics/altIdentifier/issn/0344-5704info:eu-repo/semantics/altIdentifier/issn/1432-0843info:eu-repo/semantics/altIdentifier/pmid/17576559info:eu-repo/semantics/altIdentifier/doi/10.1007/s00280-007-0532-6info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:29Zoai:sedici.unlp.edu.ar:10915/123725Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:29.782SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
spellingShingle Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
Molinuevo, María Silvina
Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
title_short Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_fullStr Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full_unstemmed Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_sort Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
dc.creator.none.fl_str_mv Molinuevo, María Silvina
Cortizo, Ana María
Etcheverry, Susana Beatriz
author Molinuevo, María Silvina
author_facet Molinuevo, María Silvina
Cortizo, Ana María
Etcheverry, Susana Beatriz
author_role author
author2 Cortizo, Ana María
Etcheverry, Susana Beatriz
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
topic Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
dc.description.none.fl_txt_mv Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this effect usually signifies serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
Facultad de Ciencias Exactas
description Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this effect usually signifies serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
publishDate 2008
dc.date.none.fl_str_mv 2008-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123725
url http://sedici.unlp.edu.ar/handle/10915/123725
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0344-5704
info:eu-repo/semantics/altIdentifier/issn/1432-0843
info:eu-repo/semantics/altIdentifier/pmid/17576559
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00280-007-0532-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
767-773
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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