Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells

Autores
Molinuevo, María S.; Cortizo, Ana María; Etcheverry, Susana B.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this eVect usually signiWes serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
Materia
Ciencias Químicas
Vanadium Metallicum
Cancer
Metastasis
Osteosarcoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/4971
Acceder
id CICBA_398ca5600e2b4d12efcc5271b76d51cc
oai_identifier_str oai:digital.cic.gba.gob.ar:11746/4971
network_acronym_str CICBA
repository_id_str 9441
network_name_str CIC Digital (CICBA)
spelling Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cellsMolinuevo, María S.Cortizo, Ana MaríaEtcheverry, Susana B.Ciencias QuímicasVanadium MetallicumCancerMetastasisOsteosarcomaVanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this eVect usually signiWes serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/4971enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-11T10:18:06Zoai:digital.cic.gba.gob.ar:11746/4971Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-11 10:18:07.007CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
spellingShingle Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
Molinuevo, María S.
Ciencias Químicas
Vanadium Metallicum
Cancer
Metastasis
Osteosarcoma
title_short Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_fullStr Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full_unstemmed Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_sort Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
dc.creator.none.fl_str_mv Molinuevo, María S.
Cortizo, Ana María
Etcheverry, Susana B.
author Molinuevo, María S.
author_facet Molinuevo, María S.
Cortizo, Ana María
Etcheverry, Susana B.
author_role author
author2 Cortizo, Ana María
Etcheverry, Susana B.
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Químicas
Vanadium Metallicum
Cancer
Metastasis
Osteosarcoma
topic Ciencias Químicas
Vanadium Metallicum
Cancer
Metastasis
Osteosarcoma
dc.description.none.fl_txt_mv Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this eVect usually signiWes serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
description Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this eVect usually signiWes serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/4971
url https://digital.cic.gba.gob.ar/handle/11746/4971
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron_str CICBA
institution CICBA
repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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score 12.993085

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