Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces

Autores
Pérez Enríquez, Darlin Johana; Dell'Arciprete, María Laura; Dittler, María Laura; Miñán, Alejandro Guillermo; Prieto, Eduardo Daniel; González, Mónica Cristina
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/141364
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/141364
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfacesPérez Enríquez, Darlin JohanaDell'Arciprete, María LauraDittler, María LauraMiñán, Alejandro GuillermoPrieto, Eduardo DanielGonzález, Mónica CristinaFísicaBiologíaCalcium phosphate nanoshellsCa2+activationsurface interactioncarboxyl groupdrug releasebacterial susceptibilityA highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2020-05-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf7541-7551http://sedici.unlp.edu.ar/handle/10915/141364enginfo:eu-repo/semantics/altIdentifier/issn/1144-0546info:eu-repo/semantics/altIdentifier/issn/1369-9261info:eu-repo/semantics/altIdentifier/doi/10.1039/c9nj06414ainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:07Zoai:sedici.unlp.edu.ar:10915/141364Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:08.161SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
spellingShingle Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
Pérez Enríquez, Darlin Johana
Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
title_short Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_full Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_fullStr Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_full_unstemmed Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_sort Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
dc.creator.none.fl_str_mv Pérez Enríquez, Darlin Johana
Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
author Pérez Enríquez, Darlin Johana
author_facet Pérez Enríquez, Darlin Johana
Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
author_role author
author2 Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
topic Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
dc.description.none.fl_txt_mv A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/141364
url http://sedici.unlp.edu.ar/handle/10915/141364
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1144-0546
info:eu-repo/semantics/altIdentifier/issn/1369-9261
info:eu-repo/semantics/altIdentifier/doi/10.1039/c9nj06414a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
7541-7551
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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