Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
- Autores
- Perez Enriquez, Darlin J.; Dell'arciprete, María L.; Dittler, María Laura; Miñan, Alejandro; Prieto, Eduardo; Gonzalez, Mónica C.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca+2 modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca+2-activated CaP nanoshell accumulation and drug release is proposed and discussed.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). - Fuente
- New Journal of Chemistry, 44(18), 7541-7551. (2020)
ISSN 1369-9261 - Materia
-
Ciencias físicas
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
- OAI Identificador
- oai:memoria.fahce.unlp.edu.ar:snrd:Jpr18706
Ver los metadatos del registro completo
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Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfacesPerez Enriquez, Darlin J.Dell'arciprete, María L.Dittler, María LauraMiñan, AlejandroPrieto, EduardoGonzalez, Mónica C.Ciencias físicasCalcium phosphate nanoshellsCa<sup>+2</sup>activationSurface interactionCarboxyl groupDrug releaseBacterial susceptibilityA highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed.Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdfNew Journal of Chemistry, 44(18), 7541-7551. (2020)ISSN 1369-9261reponame:Memoria Académica (UNLP-FAHCE)instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educacióninstacron:UNLPenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ06414Ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-09-29T11:58:19Zoai:memoria.fahce.unlp.edu.ar:snrd:Jpr18706Institucionalhttps://www.memoria.fahce.unlp.edu.ar/Universidad públicahttps://www.fahce.unlp.edu.ar/https://www.memoria.fahce.unlp.edu.ar/oaiserver.cgimemoria@fahce.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13412025-09-29 11:58:20.26Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educaciónfalse |
dc.title.none.fl_str_mv |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
title |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
spellingShingle |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces Perez Enriquez, Darlin J. Ciencias físicas Calcium phosphate nanoshells Ca<sup>+2</sup>activation Surface interaction Carboxyl group Drug release Bacterial susceptibility |
title_short |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
title_full |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
title_fullStr |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
title_full_unstemmed |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
title_sort |
Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces |
dc.creator.none.fl_str_mv |
Perez Enriquez, Darlin J. Dell'arciprete, María L. Dittler, María Laura Miñan, Alejandro Prieto, Eduardo Gonzalez, Mónica C. |
author |
Perez Enriquez, Darlin J. |
author_facet |
Perez Enriquez, Darlin J. Dell'arciprete, María L. Dittler, María Laura Miñan, Alejandro Prieto, Eduardo Gonzalez, Mónica C. |
author_role |
author |
author2 |
Dell'arciprete, María L. Dittler, María Laura Miñan, Alejandro Prieto, Eduardo Gonzalez, Mónica C. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias físicas Calcium phosphate nanoshells Ca<sup>+2</sup>activation Surface interaction Carboxyl group Drug release Bacterial susceptibility |
topic |
Ciencias físicas Calcium phosphate nanoshells Ca<sup>+2</sup>activation Surface interaction Carboxyl group Drug release Bacterial susceptibility |
dc.description.none.fl_txt_mv |
A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed. Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina. Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA). |
description |
A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf |
url |
https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ06414A |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
New Journal of Chemistry, 44(18), 7541-7551. (2020) ISSN 1369-9261 reponame:Memoria Académica (UNLP-FAHCE) instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación instacron:UNLP |
reponame_str |
Memoria Académica (UNLP-FAHCE) |
collection |
Memoria Académica (UNLP-FAHCE) |
instname_str |
Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación |
repository.mail.fl_str_mv |
memoria@fahce.unlp.edu.ar |
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