Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces

Autores
Perez Enriquez, Darlin J.; Dell'arciprete, María L.; Dittler, María Laura; Miñan, Alejandro; Prieto, Eduardo; Gonzalez, Mónica C.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca+2 modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca+2-activated CaP nanoshell accumulation and drug release is proposed and discussed.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fuente
New Journal of Chemistry, 44(18), 7541-7551. (2020)
ISSN 1369-9261
Materia
Ciencias físicas
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Memoria Académica (UNLP-FAHCE)
Institución
Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
OAI Identificador
oai:memoria.fahce.unlp.edu.ar:snrd:Jpr18706
Acceder
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network_acronym_str MemAca
repository_id_str 1341
network_name_str Memoria Académica (UNLP-FAHCE)
spelling Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfacesPerez Enriquez, Darlin J.Dell'arciprete, María L.Dittler, María LauraMiñan, AlejandroPrieto, EduardoGonzalez, Mónica C.Ciencias físicasCalcium phosphate nanoshellsCa<sup>+2</sup>activationSurface interactionCarboxyl groupDrug releaseBacterial susceptibilityA highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed.Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdfNew Journal of Chemistry, 44(18), 7541-7551. (2020)ISSN 1369-9261reponame:Memoria Académica (UNLP-FAHCE)instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educacióninstacron:UNLPenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ06414Ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-10-16T09:28:33Zoai:memoria.fahce.unlp.edu.ar:snrd:Jpr18706Institucionalhttps://www.memoria.fahce.unlp.edu.ar/Universidad públicahttps://www.fahce.unlp.edu.ar/https://www.memoria.fahce.unlp.edu.ar/oaiserver.cgimemoria@fahce.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13412025-10-16 09:28:34.934Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educaciónfalse
dc.title.none.fl_str_mv Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
title Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
spellingShingle Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
Perez Enriquez, Darlin J.
Ciencias físicas
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility
title_short Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
title_full Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
title_fullStr Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
title_full_unstemmed Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
title_sort Amorphous calcium organophosphates nanoshells as potential carriers for drug delivery to Ca<sup>+2</sup>-enriched surfaces
dc.creator.none.fl_str_mv Perez Enriquez, Darlin J.
Dell'arciprete, María L.
Dittler, María Laura
Miñan, Alejandro
Prieto, Eduardo
Gonzalez, Mónica C.
author Perez Enriquez, Darlin J.
author_facet Perez Enriquez, Darlin J.
Dell'arciprete, María L.
Dittler, María Laura
Miñan, Alejandro
Prieto, Eduardo
Gonzalez, Mónica C.
author_role author
author2 Dell'arciprete, María L.
Dittler, María Laura
Miñan, Alejandro
Prieto, Eduardo
Gonzalez, Mónica C.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias físicas
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility
topic Ciencias físicas
Calcium phosphate nanoshells
Ca<sup>+2</sup>activation
Surface interaction
Carboxyl group
Drug release
Bacterial susceptibility
dc.description.none.fl_txt_mv A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed.
Fil: Dittler, María Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
Fil: Perez Enriquez, Darlin J.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Dell'arciprete, María L.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Miñan, Alejandro. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Prieto, Eduardo. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
Fil: Gonzalez, Mónica C.. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA).
description A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca<sup>+2</sup> modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca<sup>+2</sup>-activated CaP nanoshell accumulation and drug release is proposed and discussed.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf
url https://www.memoria.fahce.unlp.edu.ar/art_revistas/pr.18706/pr.18706.pdf
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ06414A
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv New Journal of Chemistry, 44(18), 7541-7551. (2020)
ISSN 1369-9261
reponame:Memoria Académica (UNLP-FAHCE)
instname:Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
instacron:UNLP
reponame_str Memoria Académica (UNLP-FAHCE)
collection Memoria Académica (UNLP-FAHCE)
instname_str Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv Memoria Académica (UNLP-FAHCE) - Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
repository.mail.fl_str_mv memoria@fahce.unlp.edu.ar
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score 12.712165

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