Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
- Autores
- Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacón Villalba, María Elizabeth; Güida, Jorge Alberto; Mukherjee, Arup; Castro, Guillermo Raúl
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Centro de Química Inorgánica
Facultad de Ingeniería - Materia
-
Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/107013
Ver los metadatos del registro completo
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Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheresBosio, Valeria ElizabethBasu, SreyasreeAbdullha, FraqooueChacón Villalba, María ElizabethGüida, Jorge AlbertoMukherjee, ArupCastro, Guillermo RaúlQuímicaCongo RedGel microspheresGuar gumAlginateCoacervatesInfrared spectroscopyCongo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.Centro de Investigación y Desarrollo en Fermentaciones IndustrialesCentro de Química InorgánicaFacultad de Ingeniería2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf103-110http://sedici.unlp.edu.ar/handle/10915/107013enginfo:eu-repo/semantics/altIdentifier/issn/1381-5148info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:12Zoai:sedici.unlp.edu.ar:10915/107013Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:12.914SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
title |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
spellingShingle |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres Bosio, Valeria Elizabeth Química Congo Red Gel microspheres Guar gum Alginate Coacervates Infrared spectroscopy |
title_short |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
title_full |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
title_fullStr |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
title_full_unstemmed |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
title_sort |
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres |
dc.creator.none.fl_str_mv |
Bosio, Valeria Elizabeth Basu, Sreyasree Abdullha, Fraqooue Chacón Villalba, María Elizabeth Güida, Jorge Alberto Mukherjee, Arup Castro, Guillermo Raúl |
author |
Bosio, Valeria Elizabeth |
author_facet |
Bosio, Valeria Elizabeth Basu, Sreyasree Abdullha, Fraqooue Chacón Villalba, María Elizabeth Güida, Jorge Alberto Mukherjee, Arup Castro, Guillermo Raúl |
author_role |
author |
author2 |
Basu, Sreyasree Abdullha, Fraqooue Chacón Villalba, María Elizabeth Güida, Jorge Alberto Mukherjee, Arup Castro, Guillermo Raúl |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Química Congo Red Gel microspheres Guar gum Alginate Coacervates Infrared spectroscopy |
topic |
Química Congo Red Gel microspheres Guar gum Alginate Coacervates Infrared spectroscopy |
dc.description.none.fl_txt_mv |
Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation. Centro de Investigación y Desarrollo en Fermentaciones Industriales Centro de Química Inorgánica Facultad de Ingeniería |
description |
Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/107013 |
url |
http://sedici.unlp.edu.ar/handle/10915/107013 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/issn/1381-5148 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006 |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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