Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres

Autores
Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacón Villalba, María Elizabeth; Güida, Jorge Alberto; Mukherjee, Arup; Castro, Guillermo Raúl
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Centro de Química Inorgánica
Facultad de Ingeniería
Materia
Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107013

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spelling Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheresBosio, Valeria ElizabethBasu, SreyasreeAbdullha, FraqooueChacón Villalba, María ElizabethGüida, Jorge AlbertoMukherjee, ArupCastro, Guillermo RaúlQuímicaCongo RedGel microspheresGuar gumAlginateCoacervatesInfrared spectroscopyCongo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.Centro de Investigación y Desarrollo en Fermentaciones IndustrialesCentro de Química InorgánicaFacultad de Ingeniería2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf103-110http://sedici.unlp.edu.ar/handle/10915/107013enginfo:eu-repo/semantics/altIdentifier/issn/1381-5148info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:12Zoai:sedici.unlp.edu.ar:10915/107013Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:12.914SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
spellingShingle Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
Bosio, Valeria Elizabeth
Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
title_short Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_full Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_fullStr Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_full_unstemmed Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_sort Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
dc.creator.none.fl_str_mv Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
author Bosio, Valeria Elizabeth
author_facet Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
author_role author
author2 Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
topic Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
dc.description.none.fl_txt_mv Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Centro de Química Inorgánica
Facultad de Ingeniería
description Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107013
url http://sedici.unlp.edu.ar/handle/10915/107013
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1381-5148
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
103-110
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