Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper

Autores
Bosio, Valeria Elizabeth; Gomez Lopez, Azucena; Mukherjee, Arup; Mechetti, Magdalena; Castro, Guillermo Raul
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.
Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Fil: Gomez Lopez, Azucena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; Argentina
Fil: Mukherjee, Arup. Calcutta University; India
Fil: Mechetti, Magdalena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; Argentina
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Materia
Doxorrubicin
Drug Delivery
Alginate - Guar Gum
Biopolymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16071
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16071
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helperBosio, Valeria ElizabethGomez Lopez, AzucenaMukherjee, ArupMechetti, MagdalenaCastro, Guillermo RaulDoxorrubicinDrug DeliveryAlginate - Guar GumBiopolymershttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; ArgentinaFil: Gomez Lopez, Azucena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; ArgentinaFil: Mukherjee, Arup. Calcutta University; IndiaFil: Mechetti, Magdalena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; ArgentinaFil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; ArgentinaRoyal Society of Chemistry2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16071Bosio, Valeria Elizabeth; Gomez Lopez, Azucena; Mukherjee, Arup; Mechetti, Magdalena; Castro, Guillermo Raul; Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper; Royal Society of Chemistry; Journal of Materials Chemistry B; 32; -1-2014; 5178-51862050-750X2050-7518enginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c3tb20531binfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C3TB20531B#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:04Zoai:ri.conicet.gov.ar:11336/16071instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:04.736CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
spellingShingle Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
Bosio, Valeria Elizabeth
Doxorrubicin
Drug Delivery
Alginate - Guar Gum
Biopolymers
title_short Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_full Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_fullStr Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_full_unstemmed Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_sort Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
dc.creator.none.fl_str_mv Bosio, Valeria Elizabeth
Gomez Lopez, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raul
author Bosio, Valeria Elizabeth
author_facet Bosio, Valeria Elizabeth
Gomez Lopez, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raul
author_role author
author2 Gomez Lopez, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raul
author2_role author
author
author
author
dc.subject.none.fl_str_mv Doxorrubicin
Drug Delivery
Alginate - Guar Gum
Biopolymers
topic Doxorrubicin
Drug Delivery
Alginate - Guar Gum
Biopolymers
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.
Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Fil: Gomez Lopez, Azucena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; Argentina
Fil: Mukherjee, Arup. Calcutta University; India
Fil: Mechetti, Magdalena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnologia; Argentina
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
description Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16071
Bosio, Valeria Elizabeth; Gomez Lopez, Azucena; Mukherjee, Arup; Mechetti, Magdalena; Castro, Guillermo Raul; Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper; Royal Society of Chemistry; Journal of Materials Chemistry B; 32; -1-2014; 5178-5186
2050-750X
2050-7518
url http://hdl.handle.net/11336/16071
identifier_str_mv Bosio, Valeria Elizabeth; Gomez Lopez, Azucena; Mukherjee, Arup; Mechetti, Magdalena; Castro, Guillermo Raul; Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper; Royal Society of Chemistry; Journal of Materials Chemistry B; 32; -1-2014; 5178-5186
2050-750X
2050-7518
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c3tb20531b
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C3TB20531B#!divAbstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269198942732288
score 13.13397

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