Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres

Autores
Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacon Villalba, M. Elizabeth; Guida, Jorge Alberto; Mukherjee, Arup; Castro, Guillermo Raul
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 °C after 8 h incubation.
Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Fil: Basu, Sreyasree. Calcutta University; India
Fil: Abdullha, Fraqooue. Calcutta University; India
Fil: Chacon Villalba, M. Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; Argentina
Fil: Guida, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; Argentina. Universidad Nacional de Luján; Argentina
Fil: Mukherjee, Arup. Calcutta University; India
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Materia
Carboxymethyl Guar Gum
Controlled Release
Congo Red
Gel Microspheres
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16088
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16088
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheresBosio, Valeria ElizabethBasu, SreyasreeAbdullha, FraqooueChacon Villalba, M. ElizabethGuida, Jorge AlbertoMukherjee, ArupCastro, Guillermo RaulCarboxymethyl Guar GumControlled ReleaseCongo RedGel Microsphereshttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 °C after 8 h incubation.Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; ArgentinaFil: Basu, Sreyasree. Calcutta University; IndiaFil: Abdullha, Fraqooue. Calcutta University; IndiaFil: Chacon Villalba, M. Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; ArgentinaFil: Guida, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; Argentina. Universidad Nacional de Luján; ArgentinaFil: Mukherjee, Arup. Calcutta University; IndiaFil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; ArgentinaElsevier Science2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16088Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacon Villalba, M. Elizabeth; Guida, Jorge Alberto; et al.; Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres; Elsevier Science; Reactive & Functional Polymers; 82; 9-2014; 103-1101381-5148enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514814001229info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:20Zoai:ri.conicet.gov.ar:11336/16088instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:21.122CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
title Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
spellingShingle Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
Bosio, Valeria Elizabeth
Carboxymethyl Guar Gum
Controlled Release
Congo Red
Gel Microspheres
title_short Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
title_full Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
title_fullStr Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
title_full_unstemmed Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
title_sort Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres
dc.creator.none.fl_str_mv Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacon Villalba, M. Elizabeth
Guida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raul
author Bosio, Valeria Elizabeth
author_facet Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacon Villalba, M. Elizabeth
Guida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raul
author_role author
author2 Basu, Sreyasree
Abdullha, Fraqooue
Chacon Villalba, M. Elizabeth
Guida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raul
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Carboxymethyl Guar Gum
Controlled Release
Congo Red
Gel Microspheres
topic Carboxymethyl Guar Gum
Controlled Release
Congo Red
Gel Microspheres
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 °C after 8 h incubation.
Fil: Bosio, Valeria Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
Fil: Basu, Sreyasree. Calcutta University; India
Fil: Abdullha, Fraqooue. Calcutta University; India
Fil: Chacon Villalba, M. Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; Argentina
Fil: Guida, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Química Inorganica "dr. Pedro J. Aymonino". Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Química Inorganica ; Argentina. Universidad Nacional de Luján; Argentina
Fil: Mukherjee, Arup. Calcutta University; India
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
description Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 °C after 8 h incubation.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16088
Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacon Villalba, M. Elizabeth; Guida, Jorge Alberto; et al.; Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres; Elsevier Science; Reactive & Functional Polymers; 82; 9-2014; 103-110
1381-5148
url http://hdl.handle.net/11336/16088
identifier_str_mv Bosio, Valeria Elizabeth; Basu, Sreyasree; Abdullha, Fraqooue; Chacon Villalba, M. Elizabeth; Guida, Jorge Alberto; et al.; Encapsulation of Congo Red in carboxymethyl guar gum–alginate gel microspheres; Elsevier Science; Reactive & Functional Polymers; 82; 9-2014; 103-110
1381-5148
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2014.06.006
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514814001229
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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