Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity

Autores
León, Ignacio Esteban; Cadavid Vargas, Juan Fernando; Di Virgilio, Ana Laura; Etcheverry, Susana Beatriz
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor in vitro effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.
Centro de Química Inorgánica
Materia
Ciencias Exactas
Copper
Anticancer agents
Vanadium
Ruthenium
Mechanism of action
Cell in culture
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/103353

id SEDICI_888bbe8c35db2b27c358b849f4acb37e
oai_identifier_str oai:sedici.unlp.edu.ar:10915/103353
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer ActivityLeón, Ignacio EstebanCadavid Vargas, Juan FernandoDi Virgilio, Ana LauraEtcheverry, Susana BeatrizCiencias ExactasCopperAnticancer agentsVanadiumRutheniumMechanism of actionCell in cultureCancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor <i>in vitro</i> effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.Centro de Química Inorgánica2016-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-37http://sedici.unlp.edu.ar/handle/10915/103353enginfo:eu-repo/semantics/altIdentifier/url/http://eurekaselect.com/article/download/145071info:eu-repo/semantics/altIdentifier/issn/0929-8673info:eu-repo/semantics/altIdentifier/doi/10.2174/0929867323666160824162546info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:28Zoai:sedici.unlp.edu.ar:10915/103353Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:28.2SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
title Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
spellingShingle Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
León, Ignacio Esteban
Ciencias Exactas
Copper
Anticancer agents
Vanadium
Ruthenium
Mechanism of action
Cell in culture
title_short Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
title_full Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
title_fullStr Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
title_full_unstemmed Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
title_sort Vanadium, Ruthenium and Copper Compounds : A New Class of Nonplatinum Metallodrugs with Anticancer Activity
dc.creator.none.fl_str_mv León, Ignacio Esteban
Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Etcheverry, Susana Beatriz
author León, Ignacio Esteban
author_facet León, Ignacio Esteban
Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Etcheverry, Susana Beatriz
author_role author
author2 Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Etcheverry, Susana Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Copper
Anticancer agents
Vanadium
Ruthenium
Mechanism of action
Cell in culture
topic Ciencias Exactas
Copper
Anticancer agents
Vanadium
Ruthenium
Mechanism of action
Cell in culture
dc.description.none.fl_txt_mv Cancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor <i>in vitro</i> effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.
Centro de Química Inorgánica
description Cancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor <i>in vitro</i> effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/103353
url http://sedici.unlp.edu.ar/handle/10915/103353
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://eurekaselect.com/article/download/145071
info:eu-repo/semantics/altIdentifier/issn/0929-8673
info:eu-repo/semantics/altIdentifier/doi/10.2174/0929867323666160824162546
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1-37
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1844616100089692160
score 13.070432