Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds

Autores
Kljun, Jakob; Rebernik, Mihaela; Balsa, Lucia Mariana; Kladnik, Jerneja; Rapuš, Uroš; Trobec, Tomaž; Sepčić, Kristina; Frangež, Robert; Leon, Ignacio Esteban; Turel, Iztok
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosphine ligand pta (1,3,5-triaza-7-phosphaadamantane) as a functionality that improves the stability of the complex and its aqueous solubility. Here, we report our efforts to find pta alternatives and discover new structural elements to improve the biological properties of ruthenium anticancer drugs. The pta ligand was replaced by a selection of phosphine, phosphite, and arsine ligands to identify new functionalities, leading to improvement in inhibitory potency towards enzyme glutathione S-transferase. In addition, cytotoxicity in breast, bone, and colon cancers was investigated.
Fil: Kljun, Jakob. University Of Ljubljana; Eslovenia
Fil: Rebernik, Mihaela. University Of Ljubljana; Eslovenia
Fil: Balsa, Lucia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Kladnik, Jerneja. University Of Ljubljana; Eslovenia
Fil: Rapuš, Uroš. University Of Ljubljana; Eslovenia
Fil: Trobec, Tomaž. University Of Ljubljana; Eslovenia
Fil: Sepčić, Kristina. University Of Ljubljana; Eslovenia
Fil: Frangež, Robert. University Of Ljubljana; Eslovenia
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Turel, Iztok. University Of Ljubljana; Eslovenia
Materia
RUTHENIUM
CANCER
PTA
MECHANISM OF ACTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227159
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227159
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer CompoundsKljun, JakobRebernik, MihaelaBalsa, Lucia MarianaKladnik, JernejaRapuš, UrošTrobec, TomažSepčić, KristinaFrangež, RobertLeon, Ignacio EstebanTurel, IztokRUTHENIUMCANCERPTAMECHANISM OF ACTIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosphine ligand pta (1,3,5-triaza-7-phosphaadamantane) as a functionality that improves the stability of the complex and its aqueous solubility. Here, we report our efforts to find pta alternatives and discover new structural elements to improve the biological properties of ruthenium anticancer drugs. The pta ligand was replaced by a selection of phosphine, phosphite, and arsine ligands to identify new functionalities, leading to improvement in inhibitory potency towards enzyme glutathione S-transferase. In addition, cytotoxicity in breast, bone, and colon cancers was investigated.Fil: Kljun, Jakob. University Of Ljubljana; EsloveniaFil: Rebernik, Mihaela. University Of Ljubljana; EsloveniaFil: Balsa, Lucia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Kladnik, Jerneja. University Of Ljubljana; EsloveniaFil: Rapuš, Uroš. University Of Ljubljana; EsloveniaFil: Trobec, Tomaž. University Of Ljubljana; EsloveniaFil: Sepčić, Kristina. University Of Ljubljana; EsloveniaFil: Frangež, Robert. University Of Ljubljana; EsloveniaFil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Turel, Iztok. University Of Ljubljana; EsloveniaMolecular Diversity Preservation International2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227159Kljun, Jakob; Rebernik, Mihaela; Balsa, Lucia Mariana; Kladnik, Jerneja; Rapuš, Uroš; et al.; Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds; Molecular Diversity Preservation International; Molecules; 28; 6; 3-2023; 1-141420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/28/6/2499info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules28062499info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:34:26Zoai:ri.conicet.gov.ar:11336/227159instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:34:26.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
title Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
spellingShingle Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
Kljun, Jakob
RUTHENIUM
CANCER
PTA
MECHANISM OF ACTION
title_short Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
title_full Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
title_fullStr Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
title_full_unstemmed Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
title_sort Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds
dc.creator.none.fl_str_mv Kljun, Jakob
Rebernik, Mihaela
Balsa, Lucia Mariana
Kladnik, Jerneja
Rapuš, Uroš
Trobec, Tomaž
Sepčić, Kristina
Frangež, Robert
Leon, Ignacio Esteban
Turel, Iztok
author Kljun, Jakob
author_facet Kljun, Jakob
Rebernik, Mihaela
Balsa, Lucia Mariana
Kladnik, Jerneja
Rapuš, Uroš
Trobec, Tomaž
Sepčić, Kristina
Frangež, Robert
Leon, Ignacio Esteban
Turel, Iztok
author_role author
author2 Rebernik, Mihaela
Balsa, Lucia Mariana
Kladnik, Jerneja
Rapuš, Uroš
Trobec, Tomaž
Sepčić, Kristina
Frangež, Robert
Leon, Ignacio Esteban
Turel, Iztok
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RUTHENIUM
CANCER
PTA
MECHANISM OF ACTION
topic RUTHENIUM
CANCER
PTA
MECHANISM OF ACTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosphine ligand pta (1,3,5-triaza-7-phosphaadamantane) as a functionality that improves the stability of the complex and its aqueous solubility. Here, we report our efforts to find pta alternatives and discover new structural elements to improve the biological properties of ruthenium anticancer drugs. The pta ligand was replaced by a selection of phosphine, phosphite, and arsine ligands to identify new functionalities, leading to improvement in inhibitory potency towards enzyme glutathione S-transferase. In addition, cytotoxicity in breast, bone, and colon cancers was investigated.
Fil: Kljun, Jakob. University Of Ljubljana; Eslovenia
Fil: Rebernik, Mihaela. University Of Ljubljana; Eslovenia
Fil: Balsa, Lucia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Kladnik, Jerneja. University Of Ljubljana; Eslovenia
Fil: Rapuš, Uroš. University Of Ljubljana; Eslovenia
Fil: Trobec, Tomaž. University Of Ljubljana; Eslovenia
Fil: Sepčić, Kristina. University Of Ljubljana; Eslovenia
Fil: Frangež, Robert. University Of Ljubljana; Eslovenia
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Turel, Iztok. University Of Ljubljana; Eslovenia
description Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosphine ligand pta (1,3,5-triaza-7-phosphaadamantane) as a functionality that improves the stability of the complex and its aqueous solubility. Here, we report our efforts to find pta alternatives and discover new structural elements to improve the biological properties of ruthenium anticancer drugs. The pta ligand was replaced by a selection of phosphine, phosphite, and arsine ligands to identify new functionalities, leading to improvement in inhibitory potency towards enzyme glutathione S-transferase. In addition, cytotoxicity in breast, bone, and colon cancers was investigated.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227159
Kljun, Jakob; Rebernik, Mihaela; Balsa, Lucia Mariana; Kladnik, Jerneja; Rapuš, Uroš; et al.; Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds; Molecular Diversity Preservation International; Molecules; 28; 6; 3-2023; 1-14
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227159
identifier_str_mv Kljun, Jakob; Rebernik, Mihaela; Balsa, Lucia Mariana; Kladnik, Jerneja; Rapuš, Uroš; et al.; Exploring pta Alternatives in the Development of Ruthenium–Arene Anticancer Compounds; Molecular Diversity Preservation International; Molecules; 28; 6; 3-2023; 1-14
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/28/6/2499
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules28062499
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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