Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent

Autores
Escudero, Graciela Estela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Centro de Química Inorgánica
Facultad de Ciencias Exactas
Instituto de Física La Plata
Materia
Química
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/95118
Acceder
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network_name_str SEDICI (UNLP)
spelling Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant AgentEscudero, Graciela EstelaLaino, Carlos HoracioMartini, NancyEcheverría, Gustavo AlbertoPiro, Oscar EnriqueWilliams, Patricia Ana MaríaFerrer, Evelina GloriaQuímicaAntidepressantDrug designSertraline derivativeSelective serotonin reuptake inhibitorsBioavailabilityA novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.Centro de Química InorgánicaFacultad de Ciencias ExactasInstituto de Física La Plata2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-11http://sedici.unlp.edu.ar/handle/10915/95118enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/66990info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdfinfo:eu-repo/semantics/altIdentifier/issn/2378-9336info:eu-repo/semantics/altIdentifier/hdl/11336/66990info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:52:32Zoai:sedici.unlp.edu.ar:10915/95118Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:52:32.673SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
spellingShingle Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
Escudero, Graciela Estela
Química
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
title_short Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_fullStr Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full_unstemmed Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_sort Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
dc.creator.none.fl_str_mv Escudero, Graciela Estela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Escudero, Graciela Estela
author_facet Escudero, Graciela Estela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
topic Química
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
dc.description.none.fl_txt_mv A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Centro de Química Inorgánica
Facultad de Ciencias Exactas
Instituto de Física La Plata
description A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/95118
url http://sedici.unlp.edu.ar/handle/10915/95118
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/66990
info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf
info:eu-repo/semantics/altIdentifier/issn/2378-9336
info:eu-repo/semantics/altIdentifier/hdl/11336/66990
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1-11
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instname:Universidad Nacional de La Plata
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reponame_str SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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