Zn(II) based novel potential drug containing sertraline as strong antidepressant agent

Autores
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Fil: Escudero, Graciela. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina
Fil: Laino, Carlos Horacio. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina
Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Materia
Drug design
Selective serotonin reuptake inhibitors
Sertraline derivative
Antidepressant
Bioavailability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64512
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zn(II) based novel potential drug containing sertraline as strong antidepressant agentEscudero, GracielaLaino, Carlos HoracioMartini, NancyEcheverría, Gustavo AlbertoPiro, Oscar EnriqueWilliams, Patricia Ana MaríaFerrer, Evelina GloriaDrug designSelective serotonin reuptake inhibitorsSertraline derivativeAntidepressantBioavailabilityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.Fil: Escudero, Graciela. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); ArgentinaFil: Laino, Carlos Horacio. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); ArgentinaFil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaJSciMed Central2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64512Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) based novel potential drug containing sertraline as strong antidepressant agent; JSciMed Central; Annals of Medicinal Chemistry and Research; 3; 1; 2-20172378-9336CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/currentissue.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:46Zoai:ri.conicet.gov.ar:11336/64512instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:46.395CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
title Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
spellingShingle Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
Escudero, Graciela
Drug design
Selective serotonin reuptake inhibitors
Sertraline derivative
Antidepressant
Bioavailability
title_short Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
title_full Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
title_fullStr Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
title_full_unstemmed Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
title_sort Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
dc.creator.none.fl_str_mv Escudero, Graciela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Escudero, Graciela
author_facet Escudero, Graciela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Drug design
Selective serotonin reuptake inhibitors
Sertraline derivative
Antidepressant
Bioavailability
topic Drug design
Selective serotonin reuptake inhibitors
Sertraline derivative
Antidepressant
Bioavailability
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Fil: Escudero, Graciela. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina
Fil: Laino, Carlos Horacio. Instituto de Farmacia y Bioquímica del Ceniit-unlar (centro de Investigación E Innovación Tecnológica); Argentina
Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Piro, Oscar Enrique. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
description A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64512
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) based novel potential drug containing sertraline as strong antidepressant agent; JSciMed Central; Annals of Medicinal Chemistry and Research; 3; 1; 2-2017
2378-9336
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64512
identifier_str_mv Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) based novel potential drug containing sertraline as strong antidepressant agent; JSciMed Central; Annals of Medicinal Chemistry and Research; 3; 1; 2-2017
2378-9336
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf
info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/currentissue.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv JSciMed Central
publisher.none.fl_str_mv JSciMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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