Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent

Autores
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Fil: Escudero, Graciela. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina
Fil: Laino, Carlos Horacio. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina
Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Echeverría, Gustavo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Materia
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66990
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant AgentEscudero, GracielaLaino, Carlos HoracioMartini, NancyEcheverría, Gustavo AlbertoPiro, Oscar EnriqueWilliams, Patricia Ana MaríaFerrer, Evelina GloriaAntidepressantDrug designSertraline derivativeSelective serotonin reuptake inhibitorsBioavailabilityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.Fil: Escudero, Graciela. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; ArgentinaFil: Laino, Carlos Horacio. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; ArgentinaFil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Echeverría, Gustavo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaSciMedCentral2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66990Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent; SciMedCentral; Annals of Medicinal Chemistry and Research; 3; 1017; 5-2017; 1-112378-9336CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:25Zoai:ri.conicet.gov.ar:11336/66990instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:25.933CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
spellingShingle Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
Escudero, Graciela
Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
title_short Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_fullStr Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full_unstemmed Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_sort Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
dc.creator.none.fl_str_mv Escudero, Graciela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Escudero, Graciela
author_facet Escudero, Graciela
Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Laino, Carlos Horacio
Martini, Nancy
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
topic Antidepressant
Drug design
Sertraline derivative
Selective serotonin reuptake inhibitors
Bioavailability
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
Fil: Escudero, Graciela. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina
Fil: Laino, Carlos Horacio. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina
Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Echeverría, Gustavo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
description A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66990
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent; SciMedCentral; Annals of Medicinal Chemistry and Research; 3; 1017; 5-2017; 1-11
2378-9336
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66990
identifier_str_mv Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent; SciMedCentral; Annals of Medicinal Chemistry and Research; 3; 1017; 5-2017; 1-11
2378-9336
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SciMedCentral
publisher.none.fl_str_mv SciMedCentral
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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