Effects of antidepressants and soybean association in depressive menopausal women

Autores
Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.
Fil: Nina Estrella, Rose Emily. Universidad Autónoma de Santo Domingo. Faculty of Health Science. School of Physiological Sciences; República Dominicana
Fil: Landa de Gargiulo, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Lafuente, José Vicente. Universidad del Pais Vasco. Departamento de Neurociencia. Laboratorio de Neurociencia Experimental; España. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
Menopause
Depressive disorder
Soybean
Antidepressant
Serotonin Selective Reuptake inhibitor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27284
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27284
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of antidepressants and soybean association in depressive menopausal womenNina Estrella, Rose EmilyLanda de Gargiulo, AdrianaLafuente, José VicenteGargiulo, Pascual AngelMenopauseDepressive disorderSoybeanAntidepressantSerotonin Selective Reuptake inhibitorhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.Fil: Nina Estrella, Rose Emily. Universidad Autónoma de Santo Domingo. Faculty of Health Science. School of Physiological Sciences; República DominicanaFil: Landa de Gargiulo, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Lafuente, José Vicente. Universidad del Pais Vasco. Departamento de Neurociencia. Laboratorio de Neurociencia Experimental; España. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; ChileFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaPolskiego Towarzystwa Farmaceutycznego2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27284Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel; Effects of antidepressants and soybean association in depressive menopausal women; Polskiego Towarzystwa Farmaceutycznego; Acta Poloniae Pharmaceutica; 71; 2; 4-2014; 323-3270001-6837CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/2/323.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:44Zoai:ri.conicet.gov.ar:11336/27284instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:45.156CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of antidepressants and soybean association in depressive menopausal women
title Effects of antidepressants and soybean association in depressive menopausal women
spellingShingle Effects of antidepressants and soybean association in depressive menopausal women
Nina Estrella, Rose Emily
Menopause
Depressive disorder
Soybean
Antidepressant
Serotonin Selective Reuptake inhibitor
title_short Effects of antidepressants and soybean association in depressive menopausal women
title_full Effects of antidepressants and soybean association in depressive menopausal women
title_fullStr Effects of antidepressants and soybean association in depressive menopausal women
title_full_unstemmed Effects of antidepressants and soybean association in depressive menopausal women
title_sort Effects of antidepressants and soybean association in depressive menopausal women
dc.creator.none.fl_str_mv Nina Estrella, Rose Emily
Landa de Gargiulo, Adriana
Lafuente, José Vicente
Gargiulo, Pascual Angel
author Nina Estrella, Rose Emily
author_facet Nina Estrella, Rose Emily
Landa de Gargiulo, Adriana
Lafuente, José Vicente
Gargiulo, Pascual Angel
author_role author
author2 Landa de Gargiulo, Adriana
Lafuente, José Vicente
Gargiulo, Pascual Angel
author2_role author
author
author
dc.subject.none.fl_str_mv Menopause
Depressive disorder
Soybean
Antidepressant
Serotonin Selective Reuptake inhibitor
topic Menopause
Depressive disorder
Soybean
Antidepressant
Serotonin Selective Reuptake inhibitor
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.
Fil: Nina Estrella, Rose Emily. Universidad Autónoma de Santo Domingo. Faculty of Health Science. School of Physiological Sciences; República Dominicana
Fil: Landa de Gargiulo, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Lafuente, José Vicente. Universidad del Pais Vasco. Departamento de Neurociencia. Laboratorio de Neurociencia Experimental; España. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27284
Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel; Effects of antidepressants and soybean association in depressive menopausal women; Polskiego Towarzystwa Farmaceutycznego; Acta Poloniae Pharmaceutica; 71; 2; 4-2014; 323-327
0001-6837
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27284
identifier_str_mv Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel; Effects of antidepressants and soybean association in depressive menopausal women; Polskiego Towarzystwa Farmaceutycznego; Acta Poloniae Pharmaceutica; 71; 2; 4-2014; 323-327
0001-6837
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/2/323.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Polskiego Towarzystwa Farmaceutycznego
publisher.none.fl_str_mv Polskiego Towarzystwa Farmaceutycznego
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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