Morphology and dynamic scaling analysis of cell colonies with linear growth fronts
- Autores
- Huergo, María Ana Cristina; Pasquale, Miguel Ángel; Bolzán, Agustín Eduardo; Arvia, Alejandro Jorge; González, Pedro Horacio
- Año de publicación
- 2010
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The growth of linear cell colony fronts is investigated from the morphology of cell monolayer colonies, the cell size and shape distribution, the front displacement velocity, and the dynamic scaling analysis of front roughness fluctuations. At the early growth stages, colony patterns consist of rather ordered compact domains of small cells, whereas at advanced stages, an uneven distribution of cells sets in, and some large cells and cells exhibiting large filopodia are produced. Colony front profiles exhibit overhangs and behave as fractals with the dimension DF=1.2560.05. The colony fronts shift at 0.2260.02 mm min−1 average constant linear velocity and their roughness swd increases with time std. Dynamic scaling analysis of experimental and overhangcorrected growth profile data shows that w versus system width l log-log plots collapse to a single curve when l exceeds a certain threshold value lo, a width corresponding to the average diameter of few cells. Then, the influence of overhangs on the roughness dynamics becomes negligible, and a growth exponent b =0.3360.02 is derived. From the structure factor analysis of overhang-corrected profiles, a global roughness exponent as=0.5060.05 is obtained. For l.200 mm, this set of exponents fulfills the Family-Vicsek relationship. It is consistent with the predictions of the continuous Kardar-Parisi-Zhang model.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Facultad de Ciencias Médicas - Materia
- Física
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/167506
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Morphology and dynamic scaling analysis of cell colonies with linear growth frontsHuergo, María Ana CristinaPasquale, Miguel ÁngelBolzán, Agustín EduardoArvia, Alejandro JorgeGonzález, Pedro HoracioFísicaThe growth of linear cell colony fronts is investigated from the morphology of cell monolayer colonies, the cell size and shape distribution, the front displacement velocity, and the dynamic scaling analysis of front roughness fluctuations. At the early growth stages, colony patterns consist of rather ordered compact domains of small cells, whereas at advanced stages, an uneven distribution of cells sets in, and some large cells and cells exhibiting large filopodia are produced. Colony front profiles exhibit overhangs and behave as fractals with the dimension DF=1.2560.05. The colony fronts shift at 0.2260.02 mm min−1 average constant linear velocity and their roughness swd increases with time std. Dynamic scaling analysis of experimental and overhangcorrected growth profile data shows that w versus system width l log-log plots collapse to a single curve when l exceeds a certain threshold value lo, a width corresponding to the average diameter of few cells. Then, the influence of overhangs on the roughness dynamics becomes negligible, and a growth exponent b =0.3360.02 is derived. From the structure factor analysis of overhang-corrected profiles, a global roughness exponent as=0.5060.05 is obtained. For l.200 mm, this set of exponents fulfills the Family-Vicsek relationship. It is consistent with the predictions of the continuous Kardar-Parisi-Zhang model.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Médicas2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/167506spainfo:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.82.031903info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:44:36Zoai:sedici.unlp.edu.ar:10915/167506Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:44:36.742SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
title |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
spellingShingle |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts Huergo, María Ana Cristina Física |
title_short |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
title_full |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
title_fullStr |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
title_full_unstemmed |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
title_sort |
Morphology and dynamic scaling analysis of cell colonies with linear growth fronts |
dc.creator.none.fl_str_mv |
Huergo, María Ana Cristina Pasquale, Miguel Ángel Bolzán, Agustín Eduardo Arvia, Alejandro Jorge González, Pedro Horacio |
author |
Huergo, María Ana Cristina |
author_facet |
Huergo, María Ana Cristina Pasquale, Miguel Ángel Bolzán, Agustín Eduardo Arvia, Alejandro Jorge González, Pedro Horacio |
author_role |
author |
author2 |
Pasquale, Miguel Ángel Bolzán, Agustín Eduardo Arvia, Alejandro Jorge González, Pedro Horacio |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Física |
topic |
Física |
dc.description.none.fl_txt_mv |
The growth of linear cell colony fronts is investigated from the morphology of cell monolayer colonies, the cell size and shape distribution, the front displacement velocity, and the dynamic scaling analysis of front roughness fluctuations. At the early growth stages, colony patterns consist of rather ordered compact domains of small cells, whereas at advanced stages, an uneven distribution of cells sets in, and some large cells and cells exhibiting large filopodia are produced. Colony front profiles exhibit overhangs and behave as fractals with the dimension DF=1.2560.05. The colony fronts shift at 0.2260.02 mm min−1 average constant linear velocity and their roughness swd increases with time std. Dynamic scaling analysis of experimental and overhangcorrected growth profile data shows that w versus system width l log-log plots collapse to a single curve when l exceeds a certain threshold value lo, a width corresponding to the average diameter of few cells. Then, the influence of overhangs on the roughness dynamics becomes negligible, and a growth exponent b =0.3360.02 is derived. From the structure factor analysis of overhang-corrected profiles, a global roughness exponent as=0.5060.05 is obtained. For l.200 mm, this set of exponents fulfills the Family-Vicsek relationship. It is consistent with the predictions of the continuous Kardar-Parisi-Zhang model. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Facultad de Ciencias Médicas |
description |
The growth of linear cell colony fronts is investigated from the morphology of cell monolayer colonies, the cell size and shape distribution, the front displacement velocity, and the dynamic scaling analysis of front roughness fluctuations. At the early growth stages, colony patterns consist of rather ordered compact domains of small cells, whereas at advanced stages, an uneven distribution of cells sets in, and some large cells and cells exhibiting large filopodia are produced. Colony front profiles exhibit overhangs and behave as fractals with the dimension DF=1.2560.05. The colony fronts shift at 0.2260.02 mm min−1 average constant linear velocity and their roughness swd increases with time std. Dynamic scaling analysis of experimental and overhangcorrected growth profile data shows that w versus system width l log-log plots collapse to a single curve when l exceeds a certain threshold value lo, a width corresponding to the average diameter of few cells. Then, the influence of overhangs on the roughness dynamics becomes negligible, and a growth exponent b =0.3360.02 is derived. From the structure factor analysis of overhang-corrected profiles, a global roughness exponent as=0.5060.05 is obtained. For l.200 mm, this set of exponents fulfills the Family-Vicsek relationship. It is consistent with the predictions of the continuous Kardar-Parisi-Zhang model. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/167506 |
url |
http://sedici.unlp.edu.ar/handle/10915/167506 |
dc.language.none.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.82.031903 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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