Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality

Autores
Huergo, María Ana Cristina; Muzzio, Nicolás Eduardo; Pasquale, Miguel Angel; Gonzalez, Pedro Horacio; Bolzán, Agustín Eduardo; Arvia, Alejandro Jorge
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interfacial two-dimensional spreading dynamics of quasilinear Vero cell colony fronts in methylcellulose MC)-containing culture medium, under a constant average front displacement velocity regime, was investigated. Under comparable experimental conditions, the average colony front displacement velocity becomes lower than that reported for a standard culture medium. Initially, the presence of MC in the medium hinders both the colony spreading, due to a gradual change in the average size and shape of cells and their distribution in the colony, and the cell motility in the gelled medium. Furthermore, at longer culture times enlarged cells appear at random in the border region of the colony. These cells behave as obstacles (pinning sites) for the displacement of smaller cells towards the colony front. The dynamic scaling analysis of rough fronts yields the set of exponents α = 0.63 ± 0.04, β = 0.75 ± 0.05, and z = 0.84 ± 0.05, which is close to that expected for a quenched Kardar-Parisi-Zhang model.
Fil: Huergo, María Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Muzzio, Nicolás Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Gonzalez, Pedro Horacio. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Bolzán, Agustín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Arvia, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Materia
Dynamics And Fluctuations
Growth And Division
Spatiotemporal Pattern Formation in Cellular Populations
Systems Obeying Scaling Laws
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5162
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5162
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universalityHuergo, María Ana CristinaMuzzio, Nicolás EduardoPasquale, Miguel AngelGonzalez, Pedro HoracioBolzán, Agustín EduardoArvia, Alejandro JorgeDynamics And FluctuationsGrowth And DivisionSpatiotemporal Pattern Formation in Cellular PopulationsSystems Obeying Scaling Lawshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The interfacial two-dimensional spreading dynamics of quasilinear Vero cell colony fronts in methylcellulose MC)-containing culture medium, under a constant average front displacement velocity regime, was investigated. Under comparable experimental conditions, the average colony front displacement velocity becomes lower than that reported for a standard culture medium. Initially, the presence of MC in the medium hinders both the colony spreading, due to a gradual change in the average size and shape of cells and their distribution in the colony, and the cell motility in the gelled medium. Furthermore, at longer culture times enlarged cells appear at random in the border region of the colony. These cells behave as obstacles (pinning sites) for the displacement of smaller cells towards the colony front. The dynamic scaling analysis of rough fronts yields the set of exponents α = 0.63 ± 0.04, β = 0.75 ± 0.05, and z = 0.84 ± 0.05, which is close to that expected for a quenched Kardar-Parisi-Zhang model.Fil: Huergo, María Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Muzzio, Nicolás Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Gonzalez, Pedro Horacio. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Bolzán, Agustín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Arvia, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaAmerican Physical Society2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5162Huergo, María Ana Cristina; Muzzio, Nicolás Eduardo; Pasquale, Miguel Angel; Gonzalez, Pedro Horacio; Bolzán, Agustín Eduardo; et al.; Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality; American Physical Society; Physical Review E: Statistical Physics, Plasmas, Fluids And Related Interdisciplinary Topics; 90; 2; 8-2014; 22706-227061063-651Xenginfo:eu-repo/semantics/altIdentifier/pmid/25215757info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.90.022706info:eu-repo/semantics/altIdentifier/url/http://journals.aps.org/pre/abstract/10.1103/PhysRevE.90.022706info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:49Zoai:ri.conicet.gov.ar:11336/5162instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:49.816CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
title Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
spellingShingle Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
Huergo, María Ana Cristina
Dynamics And Fluctuations
Growth And Division
Spatiotemporal Pattern Formation in Cellular Populations
Systems Obeying Scaling Laws
title_short Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
title_full Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
title_fullStr Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
title_full_unstemmed Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
title_sort Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality
dc.creator.none.fl_str_mv Huergo, María Ana Cristina
Muzzio, Nicolás Eduardo
Pasquale, Miguel Angel
Gonzalez, Pedro Horacio
Bolzán, Agustín Eduardo
Arvia, Alejandro Jorge
author Huergo, María Ana Cristina
author_facet Huergo, María Ana Cristina
Muzzio, Nicolás Eduardo
Pasquale, Miguel Angel
Gonzalez, Pedro Horacio
Bolzán, Agustín Eduardo
Arvia, Alejandro Jorge
author_role author
author2 Muzzio, Nicolás Eduardo
Pasquale, Miguel Angel
Gonzalez, Pedro Horacio
Bolzán, Agustín Eduardo
Arvia, Alejandro Jorge
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Dynamics And Fluctuations
Growth And Division
Spatiotemporal Pattern Formation in Cellular Populations
Systems Obeying Scaling Laws
topic Dynamics And Fluctuations
Growth And Division
Spatiotemporal Pattern Formation in Cellular Populations
Systems Obeying Scaling Laws
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The interfacial two-dimensional spreading dynamics of quasilinear Vero cell colony fronts in methylcellulose MC)-containing culture medium, under a constant average front displacement velocity regime, was investigated. Under comparable experimental conditions, the average colony front displacement velocity becomes lower than that reported for a standard culture medium. Initially, the presence of MC in the medium hinders both the colony spreading, due to a gradual change in the average size and shape of cells and their distribution in the colony, and the cell motility in the gelled medium. Furthermore, at longer culture times enlarged cells appear at random in the border region of the colony. These cells behave as obstacles (pinning sites) for the displacement of smaller cells towards the colony front. The dynamic scaling analysis of rough fronts yields the set of exponents α = 0.63 ± 0.04, β = 0.75 ± 0.05, and z = 0.84 ± 0.05, which is close to that expected for a quenched Kardar-Parisi-Zhang model.
Fil: Huergo, María Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Muzzio, Nicolás Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Gonzalez, Pedro Horacio. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Bolzán, Agustín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Arvia, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
description The interfacial two-dimensional spreading dynamics of quasilinear Vero cell colony fronts in methylcellulose MC)-containing culture medium, under a constant average front displacement velocity regime, was investigated. Under comparable experimental conditions, the average colony front displacement velocity becomes lower than that reported for a standard culture medium. Initially, the presence of MC in the medium hinders both the colony spreading, due to a gradual change in the average size and shape of cells and their distribution in the colony, and the cell motility in the gelled medium. Furthermore, at longer culture times enlarged cells appear at random in the border region of the colony. These cells behave as obstacles (pinning sites) for the displacement of smaller cells towards the colony front. The dynamic scaling analysis of rough fronts yields the set of exponents α = 0.63 ± 0.04, β = 0.75 ± 0.05, and z = 0.84 ± 0.05, which is close to that expected for a quenched Kardar-Parisi-Zhang model.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5162
Huergo, María Ana Cristina; Muzzio, Nicolás Eduardo; Pasquale, Miguel Angel; Gonzalez, Pedro Horacio; Bolzán, Agustín Eduardo; et al.; Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality; American Physical Society; Physical Review E: Statistical Physics, Plasmas, Fluids And Related Interdisciplinary Topics; 90; 2; 8-2014; 22706-22706
1063-651X
url http://hdl.handle.net/11336/5162
identifier_str_mv Huergo, María Ana Cristina; Muzzio, Nicolás Eduardo; Pasquale, Miguel Angel; Gonzalez, Pedro Horacio; Bolzán, Agustín Eduardo; et al.; Dynamic scaling analysis of two-dimensional cell colony fronts in a gel medium: A biological system approaching a quenched Kardar-Parisi-Zhang universality; American Physical Society; Physical Review E: Statistical Physics, Plasmas, Fluids And Related Interdisciplinary Topics; 90; 2; 8-2014; 22706-22706
1063-651X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/pmid/25215757
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.90.022706
info:eu-repo/semantics/altIdentifier/url/http://journals.aps.org/pre/abstract/10.1103/PhysRevE.90.022706
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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