The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration

Autores
Errecalde, Jorge Oscar; Landoni, María Fabiana
Año de publicación
1992
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (Vd) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/143206
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/143206
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administrationErrecalde, Jorge OscarLandoni, María FabianaCiencias VeterinariasHorsesPharmacokineticsSlow release formulationTheophyllineThe pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (Vd) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.Facultad de Ciencias Veterinarias1992info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf131-138http://sedici.unlp.edu.ar/handle/10915/143206enginfo:eu-repo/semantics/altIdentifier/issn/0165-7380info:eu-repo/semantics/altIdentifier/issn/1573-7446info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01839010info:eu-repo/semantics/altIdentifier/pmid/1496815info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:13:06Zoai:sedici.unlp.edu.ar:10915/143206Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:13:07.163SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
spellingShingle The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
Errecalde, Jorge Oscar
Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
title_short The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_full The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_fullStr The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_full_unstemmed The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
title_sort The pharmacokinetics of a slow-release theophylline preparation in horses after intravenous and oral administration
dc.creator.none.fl_str_mv Errecalde, Jorge Oscar
Landoni, María Fabiana
author Errecalde, Jorge Oscar
author_facet Errecalde, Jorge Oscar
Landoni, María Fabiana
author_role author
author2 Landoni, María Fabiana
author2_role author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
topic Ciencias Veterinarias
Horses
Pharmacokinetics
Slow release formulation
Theophylline
dc.description.none.fl_txt_mv The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (Vd) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.
Facultad de Ciencias Veterinarias
description The pharmacokinetics of a slow-release theophylline formulation was investigated following intravenous and oral administration at 10 mg/kg in horses. A tricompartmental model was selected to describe the intravenous plasma profile. The elimination half-life (t1/2β) was 16.91 ± 0.93 h, the apparent volume of distribution (Vd) was 1.35 ± 0.18 L/kg and the body clearance (ClB) was 0.061 ± 0.009 L kg−1 h. After oral administration the half-life of absorption was 1.24 ± 0.30 h, and the calculated bioavailability was above 100%. Thet1/2β after oral administration was 18.51 ± 1.75 h, only a little longer than that after intravenous administration. The slow release formulation did not exhibit any advantage in prolonging thet1/2β of theophylline in the horse.
publishDate 1992
dc.date.none.fl_str_mv 1992
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/143206
url http://sedici.unlp.edu.ar/handle/10915/143206
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0165-7380
info:eu-repo/semantics/altIdentifier/issn/1573-7446
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01839010
info:eu-repo/semantics/altIdentifier/pmid/1496815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
131-138
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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