Bioavailability of butorphanol after intranasal administration to horses

Autores
Ferreira, V.; Velloso, María Inés; Landoni, Maria Fabiana
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of bu-torphanol were measured at predetermined time points using liquid chromatography/mass spectrome-try assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butor-phanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.
Fil: Ferreira, V.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
BIOAVAILABILITY
BUTORPHANOL
HORSES
INTRANASAL
PHARMACOKINETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134751
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioavailability of butorphanol after intranasal administration to horsesFerreira, V.Velloso, María InésLandoni, Maria FabianaBIOAVAILABILITYBUTORPHANOLHORSESINTRANASALPHARMACOKINETICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of bu-torphanol were measured at predetermined time points using liquid chromatography/mass spectrome-try assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butor-phanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.Fil: Ferreira, V.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaTrakia University2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134751Ferreira, V.; Velloso, María Inés; Landoni, Maria Fabiana; Bioavailability of butorphanol after intranasal administration to horses; Trakia University; Bulgarian Journal of Veterinary Medicine; 23; 4; 12-2020; 443-4471311-14771313-3543CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://tru.uni-sz.bg/bjvm/index.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.15547/bjvm.2019-0051info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:00:44Zoai:ri.conicet.gov.ar:11336/134751instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:00:45.097CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioavailability of butorphanol after intranasal administration to horses
title Bioavailability of butorphanol after intranasal administration to horses
spellingShingle Bioavailability of butorphanol after intranasal administration to horses
Ferreira, V.
BIOAVAILABILITY
BUTORPHANOL
HORSES
INTRANASAL
PHARMACOKINETICS
title_short Bioavailability of butorphanol after intranasal administration to horses
title_full Bioavailability of butorphanol after intranasal administration to horses
title_fullStr Bioavailability of butorphanol after intranasal administration to horses
title_full_unstemmed Bioavailability of butorphanol after intranasal administration to horses
title_sort Bioavailability of butorphanol after intranasal administration to horses
dc.creator.none.fl_str_mv Ferreira, V.
Velloso, María Inés
Landoni, Maria Fabiana
author Ferreira, V.
author_facet Ferreira, V.
Velloso, María Inés
Landoni, Maria Fabiana
author_role author
author2 Velloso, María Inés
Landoni, Maria Fabiana
author2_role author
author
dc.subject.none.fl_str_mv BIOAVAILABILITY
BUTORPHANOL
HORSES
INTRANASAL
PHARMACOKINETICS
topic BIOAVAILABILITY
BUTORPHANOL
HORSES
INTRANASAL
PHARMACOKINETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of bu-torphanol were measured at predetermined time points using liquid chromatography/mass spectrome-try assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butor-phanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.
Fil: Ferreira, V.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of bu-torphanol were measured at predetermined time points using liquid chromatography/mass spectrome-try assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butor-phanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134751
Ferreira, V.; Velloso, María Inés; Landoni, Maria Fabiana; Bioavailability of butorphanol after intranasal administration to horses; Trakia University; Bulgarian Journal of Veterinary Medicine; 23; 4; 12-2020; 443-447
1311-1477
1313-3543
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134751
identifier_str_mv Ferreira, V.; Velloso, María Inés; Landoni, Maria Fabiana; Bioavailability of butorphanol after intranasal administration to horses; Trakia University; Bulgarian Journal of Veterinary Medicine; 23; 4; 12-2020; 443-447
1311-1477
1313-3543
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://tru.uni-sz.bg/bjvm/index.html
info:eu-repo/semantics/altIdentifier/doi/10.15547/bjvm.2019-0051
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Trakia University
publisher.none.fl_str_mv Trakia University
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.167486

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