Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic...

Autores
Faccia, Paula Andrea; Pardini, Francisco Martín; Amalvy, Javier Ignacio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Centro de Investigación y Desarrollo en Tecnología de Pinturas
Facultad de Ingeniería
Materia
Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86640
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/86640
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugsFaccia, Paula AndreaPardini, Francisco MartínAmalvy, Javier IgnacioQuímica2-(diisoproylamino)ethyl methacrylate2-hydroxyethyl methacrylateDrug delivery systemspH-sensitive hydrogelsSmart polymersSmart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasCentro de Investigación y Desarrollo en Tecnología de PinturasFacultad de Ingeniería2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf554-566http://sedici.unlp.edu.ar/handle/10915/86640enginfo:eu-repo/semantics/altIdentifier/issn/1788-618Xinfo:eu-repo/semantics/altIdentifier/doi/10.3144/expresspolymlett.2015.52info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:17Zoai:sedici.unlp.edu.ar:10915/86640Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:17.589SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
spellingShingle Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
Faccia, Paula Andrea
Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
title_short Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_full Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_fullStr Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_full_unstemmed Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_sort Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
dc.creator.none.fl_str_mv Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier Ignacio
author Faccia, Paula Andrea
author_facet Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier Ignacio
author_role author
author2 Pardini, Francisco Martín
Amalvy, Javier Ignacio
author2_role author
author
dc.subject.none.fl_str_mv Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
topic Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
dc.description.none.fl_txt_mv Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Centro de Investigación y Desarrollo en Tecnología de Pinturas
Facultad de Ingeniería
description Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86640
url http://sedici.unlp.edu.ar/handle/10915/86640
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1788-618X
info:eu-repo/semantics/altIdentifier/doi/10.3144/expresspolymlett.2015.52
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
554-566
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instname:Universidad Nacional de La Plata
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collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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