Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments

Autores
Pardini, Francisco; Faccia, Paula; Amalvy, Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
Fil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; Argentina
Fil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina

Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
Peer Reviewed
Materia
Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/3409
Acceder
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network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developmentsPardini, FranciscoFaccia, PaulaAmalvy, JavierPolymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, FilmsSmart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.Fil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; ArgentinaFil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina
Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); ArgentinaPeer Reviewed2019-02-02T21:55:29Z2019-02-02T21:55:29Z2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfJournal of Drug Delivery Science and Technologyhttp://hdl.handle.net/20.500.12272/340910.1016/j.jddst.2015.10.016enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).Attribution-NonCommercial-NoDerivatives 4.0 Internacionalreponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2025-09-11T10:50:05Zoai:ria.utn.edu.ar:20.500.12272/3409instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-11 10:50:05.385Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
spellingShingle Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
Pardini, Francisco
Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
title_short Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_fullStr Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full_unstemmed Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_sort Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
dc.creator.none.fl_str_mv Pardini, Francisco
Faccia, Paula
Amalvy, Javier
author Pardini, Francisco
author_facet Pardini, Francisco
Faccia, Paula
Amalvy, Javier
author_role author
author2 Faccia, Paula
Amalvy, Javier
author2_role author
author
dc.subject.none.fl_str_mv Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
topic Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
dc.description.none.fl_txt_mv Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
Fil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; Argentina
Fil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina

Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
Peer Reviewed
description Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
publishDate 2015
dc.date.none.fl_str_mv 2015
2019-02-02T21:55:29Z
2019-02-02T21:55:29Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Journal of Drug Delivery Science and Technology
http://hdl.handle.net/20.500.12272/3409
10.1016/j.jddst.2015.10.016
identifier_str_mv Journal of Drug Delivery Science and Technology
10.1016/j.jddst.2015.10.016
url http://hdl.handle.net/20.500.12272/3409
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 12.993085

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